Mass Spectrometry and Analytical Pharmacology Shared Resource (MSAPSR)

Publications

Lulu Chen, Qi Zhou, Pingfeng Zhang, Wei Tan, Yingge Li, Ziwen Xu, Junfeng Ma, Gary M Kupfer, Yanxin Pei, Qibin Song, Huadong Pei. Direct stimulation of de novo nucleotide synthesis by O-GlcNAcylation. Nat Chem Biol. 2023 Jun 12. doi: 10.1038/s41589-023-01354-x. PMID: 37308732

Yingge Li, Jie Chen, Bin Wang, Ziwen Xu, Ci Wu, Junfeng Ma, Qibin Song, Qing Geng, Jinming Yu, Huadong Pei, Yi Yao. FOXK2 affects cancer cell response to chemotherapy by promoting nucleotide de novo synthesis. Drug Resist Updat. 2023 Mar;67:100926. doi: 10.1016/j.drup.2023.100926. Epub 2023 Jan 16. PMID: 36682222

Erin R. Scheidemann, Diane M. Demas, Chunyan Hou, Junfeng Ma, Wei He, Katherine N. Weilbaecher, Ayesha N. Shajahan-Haq. Resistance to abemaciclib is associated with increased metastatic potential and lysosomal protein deregulation in breast cancer cells. bioRxiv 2023.04.17.537215; doi: https://doi.org/10.1101/2023.04.17.537215

Sumita Mishra, Junfeng Ma, Desirae McKoy, Masayuki Sasaki, Federica Farinelli, Richard C Page, Mark J Ranek, Natasha Zachara, David A Kass. Transient receptor potential canonical type 6 (TRPC6) O-GlcNAcylation at Threonine-221 plays potent role in channel regulation. iScience. 2023 Feb 28;26(3):106294. doi: 10.1016/j.isci.2023.106294. eCollection 2023 Mar 17. PMID: 36936781; PMCID: PMC10014292

Shuyan Zhou, Jacob Hum, Kaan Taskintuna, Stephanie Olaya, Jeremy Steinman, Junfeng Ma, Nady Golestaneh. The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway. Antioxidants (Basel). 2023 Feb 5;12(2):385. doi: 10.3390/antiox12020385. PMID: 36829944; PMCID: PMC9952846

Ci Wu, Song Shi, Chunyan Hou, Yang Luo, Stephen Byers, Junfeng Ma. Design and Preparation of Novel Nitro-Oxide-Grafted Nanospheres with Enhanced Hydrogen Bonding Interaction for O-GlcNAc Analysis. ACS Appl. Mater. Interfaces. 2022 Oct 26;14(42):47482-47490. doi: 10.1021/acsami.2c15039. PMID: 36240223; PMCID: PMC9938961

Evgenia Gourgari, Kristen J Nadeau, Laura Pyle, Martin P Playford, Junfeng Ma, Nehal N Mehta, Alan T Remaley, Scott M Gordon. Effect of metformin on the high‐density lipoprotein proteome in youth with type 1 diabetes. Endocrinology, Diabetes & Metabolism 2021 May 9;4(3):e00261. doi: 10.1002/edm2.261. eCollection 2021 Jul. PMID: 34277985; PMCID: PMC8279605

Parnika S Kadam, Susette C Mueller, Hong Ji, Jun Liu, Amrita V Pai, Junfeng Ma, Robert C Speth, Kathryn Sandberg. Modulation of the rat angiotensin type 1a receptor by an upstream short open reading frame. Peptides. 2021 Jun;140:170529. doi: 10.1016/j.peptides.2021.170529. PMID: 33744369

Ivana Peran, Sivanesan Dakshanamurthy, Matthew D McCoy, Anastasia Mavropoulos, Bedilu Allo, Aimy Sebastian, Nicholas R Hum, Sara C Sprague, Kelly A Martin, Michael J Pishvaian, Eveline E Vietsch, Anton Wellstein, Michael B Atkins, Louis M Weiner, Andrew A Quong, Gabriela G Loots, Stephen S Yoo, Shahin Assefnia, Stephen W Byers. Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice. Gastroenterology. 2021 Mar;160(4):1359-1372.e13. doi: 10.1053/j.gastro.2020.11.044. Epub 2020 Dec 9. PMID: 33307028; PMCID: PMC7956114

Michael Girgis, Yaoxiang Li, Junfeng Ma, Miloslav Sanda, Stephen Y Wise, Oluseyi O Fatanmi, Michael D Kaytor, Amrita K Cheema, Vijay K Singh. Comparative proteomic analysis of serum from nonhuman primates administered BIO 300: a promising radiation countermeasure. Sci. Rep. 2020 Nov 9;10(1):19343. doi: 10.1038/s41598-020-76494-4. PMID: 33168863; PMCID: PMC7653926

Inhibition of the mitochondrial citrate carrier, Slc25a1, reverts steatosis, glucose intolerance, and inflammation in preclinical models of NAFLD/NASH. Tan M, Mosaoa R, Graham GT, Kasprzyk-Pawelec A, Gadre S, Parasido E, Catalina-Rodriguez O, Foley P, Giaccone G, Cheema A, Kallakury B, Albanese C, Yi C, Avantaggiati ML. Cell Death Differ. 2020 Jul;27(7):2143-2157. doi: 10.1038/s41418-020-0491-6. Epub 2020 Jan 20. PMID: 31959914

Plasma metabolite biomarkers predictive of radiation induced cardiotoxicity. Unger K, Li Y, Yeh C, Barac A, Srichai MB, Ballew EA, Girgis M, Jayatilake M, Sridharan V, Boerma M, Cheema AK. Radiother Oncol. 2020 Apr 20:S0167-8140(20)30199-7. doi: 10.1016/j.radonc.2020.04.018. PMID:32360032

Evgenia Gourgari, Junfeng Ma, Martin P Playford, Nehal N Mehta, Radoslav Goldman, Alan T Remaley, Scott M Gordon. Proteomic alterations of HDL in youth with type 1 diabetes and their associations with glycemic control: a case-control study. Cardiovasc Diabetol 2019 Mar 28;18(1):43. doi: 10.1186/s12933-019-0846-9. PMID: 30922315; PMCID: PMC6437869

Dalal S Aldeghaither, David J Zahavi, Joseph C Murray, Elana J Fertig, Garrett T Graham, Yong-Wei Zhang, Allison O’Connell, Junfeng Ma, Sandra A Jablonski, Louis M Weiner. A mechanism of resistance to antibody-targeted immune attack. Cancer Immunol. Res. 7(2), 230-243. 2019 Feb;7(2):230-243. doi: 10.1158/2326-6066.CIR-18-0266. Epub 2018 Dec 18. PMID: 30563830; PMCID: PMC6359950

Serum lipidomic analysis from mixed neutron/X-ray radiation fields reveals a hyperlipidemic and pro-inflammatory phenotype. Laiakis EC, Canadell MP, Grilj V, Harken AD, Garty GY, Astarita G, Brenner DJ, Smilenov L, Fornace AJ Jr. Sci Rep. 2019 Mar 14;9(1):4539. doi: 10.1038/s41598-019-41083-7. PMID:30872747

Plasma-derived extracellular vesicles yield predictive markers of cranial irradiation exposure in mice. Hinzman CP, Baulch JE, Mehta KY, Girgis M, Bansal S, Gill K, Li Y, Limoli CL, Cheema AK. Sci Rep. 2019 Jul 1;9(1):9460. doi: 10.1038/s41598-019-45970-x. PMID:31263197

Proteomic alterations of HDL in youth with type 1 diabetes and their associations with glycemic control: a case-control study. Gourgari E, Ma J, Playford MP, Mehta NN, Goldman R, Remaley AT, Gordon SM. Cardiovasc Diabetol. 2019 Mar 28;18(1):43. doi: 10.1186/s12933-019-0846-9. PMID: 30922315 | PMCID: PMC6437869

O‑GlcNAc Site Mapping by Using a Combination of Chemoenzymatic Labeling, Copper-Free Click Chemistry, Reductive Cleavage, and Electron-Transfer Dissociation Mass Spectrometry. Ma J, Wang W-H, Li Z, Shabanowitz J,Hunt DF, Hart GW. Anal Chem. 2019 Feb 19; 91(4): 2620–2625. Published online 2019 Feb 4. doi: 10.1021/acs.analchem.8b05688. PMCID: PMC6756848 |PMID: 30657688

A Mechanism of Resistance to Antibody-Targeted Immune Attack. Aldeghaither DS, Zahavi DJ, Murray JC, Fertig EJ, Graham GT, Zhang YW, O’Connell A, Ma J, Jablonski SA, Weiner LM. Cancer Immunol Res. 2019 Feb;7(2):230-243. doi: 10.1158/2326-6066.CIR-18-0266. Epub 2018 Dec 18. PMID: 30563830 | PMCID: PMC6359950

Prevention of Lipid Peroxidation-derived Cyclic DNA Adduct and Mutation in High-Fat Diet-induced Hepatocarcinogenesis by Theaphenon E. Coia H, Ma N, Hou Y, Dyba MD, Fu Y, Cruz MI, Benitez C, Graham GT, McCutcheon JN, Zheng YL, Sun B, Kallakury BV, Ma J, Fang HB, Berry DL, Muralidaran V, Chung FL. Cancer Prev Res (Phila). 2018 Oct;11(10):665-676. doi: 10.1158/1940-6207.CAPR-18-0160. Epub 2018 Aug 21. PMID: 30131435 |PMCID: PMC6171362

Quantitative analysis of core fucosylation of serum proteins in liver diseases by LC-MS-MRM. Ma J, Sanda M, Wei R, Zhang L, Goldman R. J Proteomics. 2018 Oct 30;189:67-74. doi: 10.1016/j.jprot.2018.02.003. Epub 2018 Feb 7. PMID: 29427759 |PMCID: PMC6350774

Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK. 2017. Microbiome. 2017 Aug 18;5(1):105. doi: 10.1186/s40168-017-0325-z. PubMed:28821301