Medicinal Chemistry Shared Resource (MCSR)


Palladium and Nickel Catalyzed Suzuki Cross-Coupling with Alkyl Fluorides. Balaraman, K.; Wolf, C.
Org. Lett. 202123, ASAP.

Optical Deciphering of Multinary Chiral Compound Mixtures Through Organic Reaction Based Chemometric Chirality Sensing. Hassan, D. S.; Wolf, C. Nat. Comm. 202112, 6451.

Chemoselective Bioconjugation Based on Modular Click Chemistry with 4-Halocoumarins and Aryl Sulfonates. Thanzeel, F. Y.; Wolf, C. RSC Adv. 202111, 18960-18965.

Catalytic Asymmetric Allylic Amination with Isatins Sulfonamides, Imides, Amines, and N-Heterocycles. Lynch, C. C.;  Balaraman, K.; Wolf, C. Org. Lett. 202022, 3180-3184. PMC32255635

Quantitative Chiroptical Sensing of Free Amino acids, Biothiols, Amines and Amino Alcohols with an Aryl Fluoride Probe. Thanzeel, F. Y.; Sripada, A.; Wolf, C. J. Am. Chem. Soc. 2019141, 16382-16387. PMC31564090

Catalytic Asymmetric Mannich Reaction of α-Fluoronitriles with Ketimines: Enantioselective and Diastereodivergent Construction of Vicinal Tetrasubstituted Stereocenters. Ding, R.; De los Santos, Z. A.; Wolf, C. ACS Catal. 2019, 9, 2169-2176. PMC6449049

Catalytic Enantioselective Ynamide Additions to Isatins: Concise Access to Oxindole Alkaloids. Moskowitz, M.; Wolf, C. Angew. Chem. Int. Ed. 2019, 58, 3402-3406. PMC6444906

Click Chemistry Enables Quantitative Chiroptical Sensing of Chiral Compounds in Protic Media and Complex Mixtures. Thanzeel, F. Y. Balaraman, K.; Wolf, C. Nat. Comm. 20189, 5323. PMC6294054 (new window)

Organocatalytic Decarboxylative Cyanomethylation of Difluoromethyl and Trifluoromethyl Ketones. Balaraman, K.; Moskowitz, M.; Wolf, C. Adv. Synth. Catal. 2018, 360, 4705-4709. PMC6615566

Organocatalytic Asymmetric Synthesis of a-Oxetanyl and a-Azetidinyl Tertiary Alkyl Fluorides and Chlorides. Ding, R.; Wolf, C. Org. Lett. 2018, 20, 892-895. PMC5937693

Organocatalytic Stereoselective Synthesis of Fluorinated 3,3′-Linked Bisoxindoles. Moskowitz, M.; Balaraman, K.; Wolf, C. J. Org. Chem. 2018, 83, 1661-1666. PMC5939997

Novel Ubiquitin Specific Protease-13 Inhibitors May Alleviate Neurodegenerative Pathology. Liu, X.; Kaluvu, B.; Lynch, C. C.; Hebron, M.; Wolf, C.; Moussa, C. Metabolites 202111, 622. PMC8467576

Discoidin Domain Receptor 1 is a Therapeutic Target for Neurodegenerative Diseases. Fowler, A. J.; Hebron, M.; Balaraman, K.; Shi, W.; Missner, A. A.; Greenzaid, J. D.; Chiu, T. L.; Ullman, C.; Weatherdon, E.; Duka, V.; Torres-Yaghi, Y.; Pagan, F. L.; Liu, X.; Ressom, H.; Ahn, J.; Wolf, C.; Moussa, C. Hum. Mol. Genet. 2020, 29, 2882-2898. PMC7566445


Bone Cancer Research Trust UK, 2nd Generation Clofarabine Derivatives as CD99 Inhibitors, $90,000 for 2020-2021, Role: Co-PI (A. Uren, GUMC, PI).