Multi-step synthesis of milligram to gram quantities of organic compounds of high quality (based on 1D NMR spectroscopy, 2D NMR, HPLC, elemental analysis, mass spectrometry, X-ray analysis) for in vitro and in vivo testing.
Structure elucidation and purity control of compounds obtained from outside sources.
Determination of physicochemical property profiles for new chemical entities.
Design and preparation of probes, labeled drugs etc. to evaluate drug target selectivity, metabolism, drug resistance mechanism etc.
Development of structure-activity relationships to provide guidance and support for drug discovery efforts.
Letters of support, generation of preliminary results, and assistance in the writing of grants.
Instrumentation and methodology available includes:
The MCSR uses modern equipment for the synthesis of known and new compounds, full compound characterization and purity control.
Drug discovery and development efforts rely on the making of new and known compounds for in vitro and in vivo testing. Typically, but not necessarily, synthetic protocols for the making of reported compounds can be obtained from the literature. Sometimes published procedures need to be modified or new synthetic routes have to be developed. Upscaling may be needed and this can require additional method development. In the case of new compounds, new synthetic strategies have to be designed and complicate reaction or even methodology development can become necessary. The MCSR has in-depth experience with multi-step synthesis of milligram to gram quantities of pharmaceutically relevant compounds of high quality (based on 1D and 2D NMR spectroscopy, elemental analysis, mass spectrometry, X-ray analysis etc.). This is extended by strong expertise with synthetic methodology development including asymmetric synthesis and catalysis.
Drug candidates and probes obtained from outside sources, for example in chemical libraries, or compounds that have been stored for a long time may not be pure and have degraded. The identity, stereochemistry (in particular of chiral compounds) and purity of compounds should be examined and verified prior to use. The MCSR performs structure elucidation, compound characterization and purity control based on NMR, UV, IR and other spectroscopic methods, ccmbustion analysis, mass spectrometry, chromatography etc. These and various compound purification techniques are used on a daily basis.
