The Georgetown University Seal represented on a stained glass window.In 1970, the Georgetown University Medical Center authorized the establishment of a cancer center named in honor of Vincent T. Lombardi, former coach of the Green Bay Packers and the Washington Redskins, who was treated for cancer at Georgetown University Hospital. Today, the Lombardi Comprehensive Cancer Center remains a valued member of Georgetown University.

Lombardi was established with funds from the University, federal government and private sources. John F. Potter, MD was the founding director. In 1974, in conjunction with Howard University, Lombardi became the 16th National Cancer Institute—designated Comprehensive Cancer Center. The designation was renewed in 1990 as a single site under the direction of director Dr. Marc Lippman, again in 2003 under Dr. Richard Pestell, and most recently in 2014 under the leadership of its current director, Dr. Louis M. Weiner.

Georgetown Lombardi Comprehensive Cancer Center continues to demonstrate significant growth in clinical and research faculty membership. Likewise, peer-reviewed funding for cancer research, treatment, education and community outreach activities continues to increase.

The primary objective of the Georgetown Lombardi Comprehensive Cancer Center is—and always has been—to provide the most advanced treatments available to Lombardi patients and, ultimately, to find a cure for this devastating disease. To this end, Lombardi's leadership aggressively encourages and supports multi-programmatic and multidisciplinary research.

Lombardi maintains a committment to the highest quality patient care. In June 2000, the Georgetown University Hospital became part of MedStar Health, a not-for-profit network of seven hospitals in the DC and Baltimore areas. The partnership between Georgetown Lombardi Comprehensive Cancer Center and MedStar/Georgetown University Hospital ensures that patients have access to leading-edge cancer care, provided by dedicated cancer professionals in a supportive and caring setting.