Program Leaders

Robert Clarke, PhD, DSc
Claudine Isaacs, MD

Program Overview

The primary mission of the Lombardi Comprehensive Cancer Center (LCCC) Breast Cancer (BC) Program is to support its members in integrating and expanding high quality/high impact basic, translational, clinical, and population based research in breast cancer. Members collaborate across three thematic areas to advance their research, with the ultimate goal of preventing and curing this disease. 

The BC Program comprises 24 full members and nine associate members representing an interdisciplinary group of basic scientists, translational scientists and clinicians who are involved in studies ranging from preclinical models to breast cancer treatment and outcomes. The program also includes: an active breast cancer patient advocacy group; support for development of novel investigator-initiated clinical trials across MedStar Georgetown University Hospital and MedStar Washington Hospital Center; and outreach and research initiatives among minority communities within our catchment area.

The scientific goals of the BC Program are achieved by the innovative and interdisciplinary mix of basic, translational, clinical, and population research that occurs across three broad thematic areas of breast cancer research.

  • Theme 1: To advance understanding of the cellular and molecular determinants of responsiveness to endocrine therapies in breast cancer in both preclinical models and clinical trials with the ultimate goal of breast cancer prevention and cure.
  • Theme 2: To elucidate the effects of nutritional, environmental, and/or genetic risk factors on breast cancer susceptibility in experimental models and humans.
  • Theme 3: To explore the clinical, therapeutic, molecular, and social factors impacting the treatment and progression of breast cancer.

Additional Resources

Full Members