TCBSR Publications

2017

Targeted nanoplex carrying siRNA against MALAT1 sensitizes glioblastoma to temozolomide; Kim SS, Harford JB, Moghe M, Rait A, Pirollo KF, Chang EH; Nucleic Acid Res. 2017 Nov 30. doi: 10.1093/nar/gkx1221. [Epub ahead of print]; PMID: 29202181  

Immune correlates of GM-CSF and melanoma peptide vaccination in a randomized trial for the adjuvant therapy of resected high-risk melanoma (E4697); Butterfield LH, Zhao F, Lee S, Tarhibi AA, Margolin KA, White RL, Atkins MB, Cohen GI, Whiteside TL, Kirkwood JM, Lawson DH; Clin Cancer Res. 2017 Sep 1;23(17): 5034-5043. doi: 10.1158/1078-0432. CCR-16-3016. Epub 2017 May 23.; PMID: 28536308; PMCID: 5581724

Inhibition of the oncogenic fusion protein EWS-FLI1 causes G2-M cell cycle arrest and enhanced vincristine sensitivity in Ewing’s sarcoma; Zollner SK, Selvanathan SP, Graham GT, Commins RMT, Hong SH, Moseley E, Parks S, Haladyna JN, Erkizan HV, Dirksen U, Hogarty MD, Uren A, Toretsky JA; Sci Signal. 2017 Oct 3;10(499). Pii: eaam8429. doi: 10.1126/scisignal.aam8429.; PMID: 28974650  

Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation; Zhang Y, Dakic A, Chen R, Dai Y, Schlegel R, Liu X; Oncotarget. 2017 Oct 25;8(56):96323-96339. doi: 10.18632/oncotarget.22036. eCollection 2017 Nov 10. PMID: 29221209 PMCID: 5707103

Multiple roles of RARRES1 in prostate cancer: Autophagy induction and angiogenesis inhibition; Roy A, Ramalinga M, Kim OJ, Chijioke J, Lynch S, Byers S, Kumar D PLoS One. 2017 Jul 5; 12(7):e0180344. doi: 10.1371/journal.pone.0180344. eCollection 2017 PMID: 28678839 PMCID: 5498036

Correction of PTEN mutations in glioblastoma cell lines via AAV-mediated gene editing; Hill VK, Kim JS, James CD, Waldman T PLoS One. 2017 May 2; 12(5):e0176683. doi: 10.1371/journal.pone.0176683. eCollection 2017 PMID: 28464039 PMCID: 5413031

Conditional cell reprogramming involves non-canonical β-catenin activation and mTOR-mediated inactivation of Akt; Suprynowicz FA, Kamonjoh CM, Krawczyk E, Agarwal S, Wellstein A, Ahboke FA, Choudhury S, Liu X, Schlegel R PLoS One. 2017 Jul 10; 12(7):e0180897. doi: 10.1371/journal.pone.0180897. eCollection 2017 PMID: 28700668 PMCID: 5507294

Mutagenic potential of hypoxanthine in live human cells; DeVito S, Woodrick J, Song L, Roy R Mutat Res. 2017 Oct;803-805:9-16. doi: 10.1016/j.mrfmmm.2017.06.005. Epub 2017 Jun 28. PMID: 28704682 PMCID: 5623627

A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis; Bong YS, Assefnia S, Tuohy T, Neklason DW, Burt RW, Ahn J, Bueno De Mesquita PJ, Byers SW Oncotarget. 2016 Dec 6; 7(49):80508-80520. doi: 10.18632/oncotarget.12768.  PMID: 27768599 PMCID: 5348337

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma; Simbulan-Rosenthal CM, Dakshanamurthy S, Gaur A,  Chen YS, Rahim S, Fang HB, Abdussamad M, Zhou H, Zapas J, Calvert V, Petricoin EF, Atkins MB, Byers SW, Rosenthal DS Oncotarget. 2017 Feb 21; 8(8): 12576-12595. doi: 10.18632/oncotarget.14990.  PMID: 28157711 PMCID: 5355037

Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer; Timofeeva OA, Palechor-Ceron N, Li G, Yuan H, Krawczyk E, Zhong X, Liu G, Upadhyay G, Dakic A, Yu S, Fang S, Choudhury S, Zhang X, Ju A, Lee MS, Dan HC, Ji Y, Hou Y, Zheng YL, Albanese C, Rhim J, Schlegel R, Dritschilo A, Liu X Oncotarget. 2017 Apr 4; 8(14):22741-22758. doi: 10.18632/oncotarget.13937.  PMID: 28009986 PMCID: 5410259

A new sub-pathway of long-patch base excision repair involving 5′ gap formation; Woodrisk J, Gupta S, Camacho S, Parvathaneni S, Choudhury S, Cheema A, Bai Y, Khatkar P, Erkizan HV, Sami F, Su Y, Sharer OD, Sharma S, Roy R EMBO J 2017 Jum 1; 36(11): 1605-1622. doi: 10.15252/embj.201694920. Epub 2017 Apr 3. PMID: 28373211 PMCID: 5452013

Conditional reprogramming and long-term expansion of normal and tumor cells from human biospecimens; Liu X, Krawczyk E, Suprynowicz FA, Palechor-Ceron N, Yuan H, Dakic A, Simic V, Zheng YL, Sripadhan P, Chen C, Lu J, Hou TW, Choudhury S, Kallakury B, Tang D, Darling T, Thangapazham R, Timofeeva O, Dritschilo A, Randell SH, Albanese C, Agarwal S, Schlegel R Nat Protoc. 2017 Feb; 12(2):439-451. doi: 10.1038/nprot2016.174. Epub 2017 Jan 26. PMID: 28125105  

Alteration of mammary gland development and gene expression by in utero exposure to cadmium; Parodi DA, Greenfield M, Evans C, Chichura A, Alpaugh A, Williams J, Cyrus KC, Martin MB Int J Mol Sci. 2017 Sep 9;18(9). Pii:E1939. doi: 10.3390/ijms18091939 PMID: 28891935 PMCID: 5618588

Circulating microRNAs in patients with hormone receptor-positive, metastatic breast cancer treated with dovitinib; Shivapurkar N, Vietsch EE, Carney E, Isaacs C, Wellstein A Clin Transl Med. 2017 Oct 4;6(1):37. doi: 10.1186/s40169-017-0169-y PMID: 28980224 PMCID: 5628092

Integrated molecular analysis of Tamoxifen-resistant invasive lobular breast cancer cells identifies MAPK and GRM/mGluR signaling as therapeutic vulnerabilities; Stires H, Heckler MM, Fu X, Li Z, Grasso CS, Quist MJ, Lewis JA, Klimach U, Zwart A, Mahajan A, Gyorffy B, Cavalli LR, Riggins RB   Mol Cell Endocrinol. 2017 Sep 19. doi: 10.1016/j.mce.2017.09.024. [Epub ahead of print]  PMID: 28935545  

Genomic comparison of early-passage conditionally reprogrammed breast cancer cells to their corresponding primary tumors; Mahajan AS, Sugita BM, Duttargi AN, Saenz F, Krawczyk E, McCutcheon JN, Gonseca AS, Kallakury B, Pohlmann P, Gusev Y, Cavalli LR PLoS One. 2017 Oct 19;12(10):e0186190. doi: 10.1371/journal.pone.0186190. eCollection 2017. PMID: 29049316 PMCID: 5648156

EGR1 regulates cellular metabolism and survival in endocrine resistant breast cancer; Shajahan-Haq AN, Boca SM, Jin L, Bhuvaneshwar K, Gusev Y, Cheema AK, Demas DD, Raghavan KS, Michalek R, Madhavan S, Clarke R Oncotarget. 2017 May 30;8(57):96865-96884. doi: 10.18632/oncotarget.18292. eCollection 2017 Nov 14. PMID: 29228577 PMCID: 5722529

RNA interference screening to identify proliferation determinants in breast cancer cells; Zhang YW, Nasto RE, Jablonski SA, Serebriiskii IG, Surana R, Murray J,  Johnson M, Riggins RB, Clarke R, Golemis EA, Weiner LM Bio Protoc. 2017;7(15). Pii. E2435. doi: 10.21769/BioProtoc.2435. Epub 2017 Aug 5 PMID: 29250574 PMCID: 5730085

Differential prioritization of therapies to subtypes of triple negative breast cancer using a systems medicine method; Wathieu H, Issa NT, Fernandez AI, Mohandoss M, Tiek DM, Franke JL, Byers SW, Riggins RB, Dakshanamurthy S Oncotarget. 2017 Oct 9;8(54):92926-92942. doi: 10.18632/oncotarget.21669. eCollection 2017 Nov 3. PMID: 29190967 PMCID: 5696233

Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion; Berens EB, Sharif GM, Schmidt MO, Yan G, Shuptrine CW, Weiner LM, Glasgow E, Riegel AT, Wellstein A Oncogene. 2017 Feb 2;36(5):593-605. doi: 10.1038/onc.2016.234. Epub 2016 Jul 4 PMID: 27375028 PMCID: 5215748

Selective inhibition of Prostatin in human enterocytes by the integral membrane kunitiz-type protease inhibitor HAI-2; Shiao F, Liu LO, Huang N, Lai YJ, Barndt RJ, Tseng CC, Wang JK, Jia B, Johnson MD, Lin CY  PLoS One. 2017 Jan 26;12(1): e0170944. doi: 10.1371/journal.pone.0170944. eCollection 2017 PMID: 28125689 PMCID: 5268426

HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6/E7 viral oncogenes; Yuan H, Krawczyk E, Blancato J, Albanese C, Zhou D, Wang N, Paul S, Alkhilaiwi F, Palechor-Ceron N, Dakic A, Fang S, Choudhary S, Hou TW, Zheng YL, Haddad BR, Usuda Y, Hartmann D, Symer D, Gillison M. Agarwal S, Wangsa D, Ried T, Liu X, Schelgel R Sci Rep. 2017 Apr 5;7:45617. doi: 10.1038/srep45617 PMID: 28378747 PMCID: 5381214

2016

Rac1-mediated DNA damage and inflammation promote Nf2 tumorigenesis but also limit cell-cycle progression; Shi Y, Bollam SR, White SM, Laughlin SZ, Graham GT, Wadhwa M, Chen H, Nguyen C, Vitte J, Giovannini M, Toretsky J, Yi C. Dev Cell. 2016 Nov 21;39(4):452-465. doi: 10.1016/j.devcel.2016.09.027. Epub 2016 Nov 3. PMID: 27818180 PMCID: 5519326

Circulating biomarkers to monitor cancer progression and treatment; Rapisuwon S, Vitsch EE, Wellstein A Comput Struct Biotechnol J. 2016 Jun 1;14:211-22. doi: 10.1016/j.csbj.2016.05.004. eCollection 2016 PMID: 27358717 PMCID: 4913179

Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth; Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, Wang X, Cruz I, Berry D, Kallakury B, Mueller SC, Agostino SD, Blandino G, Avantagiatti ML, Chung FL Cell Death Differ. 2016 Oct;23(10):1615-27. doi: 10.1038/cdd.2016.48. Epub 2016 Jun 3 PMID: 27258787 PMCID: 5041190

Discordance between Cobas BRAF V600 testing and VE1 immunohistochemistry in a melanoma patient with bone marrow metastases; Rapisuwon S, Busam KJ, Parks K, Chapmen PB, Lee E, Atkins MB Am J Dermatopathol. 2016 Sep;38(9):687-9. doi: 10.1097/DAD.000000000000660 PMID: 27541170 PMCID: 5510737

Cohesion mutations in human cancer; Hill VK, Kim JS, Waldman T Biochim Biophys Acta. 2016 Aug; 1866(1): 1-11. doi: 10.1016/j.bbcan.2016.05.002. Epub 2016 May 17. Review PMID: 27207471 PMCID: 4980180

Inhibition of DNA damage repair by the CDK4/6 inhibitor palbociclib delays irradiated intracranial atrypical teratoid rhabdoid tumor and glioblastoma xenograft regrowth; Hashizume R, Zhang A, Mueller S, Prados MD, Lulla RR, Goldman S, Saratsis AM, Mazar AP, Stegh AH, Cheng SY, Horbinski C, Haas-Kogan DA, Sarkaria JN, Waldman T, James CD Neuro Oncol. 2016 Nov; 18(11):1519-1528. doi: 10.1093/neuonc/now106. Epub 2016 Jul 1. PMID: 27370397 PMCID: 5063519

The inaugural use of gene editing for the study of tumor suppressor pathways in human cells- p21WAF1/CIP1; Waldman T. Cancer Res. 2016 Aug 15; 76(16): 4598-601. doi: 10.1158/0008-5472. CAN-16-1972. PMID: 27528579  

ROCK inhibitor reduces Myc-induced apoptosis and mediates immortalization of human keratinocytes; Dakic A, DiVito K, Fang S, Suprynowicz F, Gaur A, Li X, Palechor-Ceron N, Simic V, Choudhury S, Yu S, Simbulan-Rosenthal CM, Rosenthal D, Schlegel R, Liu X Oncotarget. 2016 Oct 11;7(41):66740-66753. doi: 10.18632/oncotarget.11458.  PMID: 27556514 PMCID: 5341834

Differential effects of superoxide and hydrogen peroxide on mycogenic signaling, membrane potential, and contractions of mouse renal afferent arterioles; Li L, Lai EY, Wellstein A, Welch WJ, Wilcox CS Am J Physiol Renal Physiol. 2016 Jun 1;310(11):F1197-205. doi: 10.1152/ajprenal.00575.2015. Epub 2016 Apr 6. PMID: 27053691 PMCID: 4935773

CRKL mediates EML4-ALK signaling and is a potential therapeutic target for ALK-rearranged lung adenocarcinoma; An R, Wang Y, Voeller D, Gower A, Kim IK, Zhang YW, Giaccone G Oncotarget. 2016 May 17;7(20): 29199-210. doi: 10.18632/oncotarget.8638.  PMID: 27078848 PMCID: 5045389

PI3K as a potential therapeutic target in thymic epithelial tumors; Alberobello AT, Wang Y, Beerkens FJ, Conforti F, McCutcheon JN, Rao G, Raffeld M, Liu J, Rahhal R, Zhang YW, Giaccone G J Thorac Oncol. 2016 Aug; 11(8): 1345-56. doi: 10.1016/j.jtho.2016.04.013. Epub 2016 Apr 24 PMID: 27117832 PMCID: 5319212

Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing; Kont YS, Dutta A, Mallisetty A, Mathew J, Minas T, Kraus C, Dhopeshwarkar P, Kallakury B, Mitra S, Uren A, Adhikari S DNA Repair (Amst). 2016 Jul;43:38-47. doi: 10.1016/j.dnarep.2016.04.009. Epub 2016 May 7 PMID: 27235629  

Cohesion mutations in human cancer; Hill VK, Kim JS, Waldman T Biochim Biophys Acta. 2016 Aug; 1866(1): 1-11. doi: 10.1016/j.bbcan.2016.05.002. Epub 2016 May 17 PMID: 27207471 PMCID: 4980180

Ezrin inhibition up-regulates stress response gene expression; Celik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X, Ozdmerli M, Ayhan A, Rudek MA, Toretsky JA, Uren A J Biol Chem. 2016 Jun 17;291(25):13257-70. doi: 10.1074/jbc.M116.718189. Epub 2016 May 2 PMID: 27137931 PMCID: 4933238

Nucleotide excision repair deficiency increases levels of acrolein-derived cyclic DNA adduct and sensitizes cells to apoptosis induced by docosahexaenoic acid and acrolein; Pan J, Sinclair E, Xuan Z, Dyba M, Fu Y, Sen S, Berry D, Creswell K, Hu J, Roy R, Chung FL Mutat Res. 2016 Jul; 789:33-8. doi: 10.1016/j.mrfmmm.2016.02.011. Epub 2016 Mar 16 PMID: 27036235  

Distinct lymphocyte antigens 6 (Ly6) family members Ly6D, Ly6E, Ly6K and Ly6H drive tumorigenesis and clinical outcome; Luo L, McGarvey P, Madhavan S, Kumar R, Gusev Y, Upadhyay G Oncotarget. 2016 Mar 8; 7(10):11165-93. doi: 10.18632/oncotarget.7163  PMID: 26862846 PMCID: 4905465

Intratumoral CD3 and CD8 T-cell densities associated with relapse free survival in HCC; Gabrielson A, Wu Y, Wang H, Jiang J, Kallakury B, Gatalica Z, Reddy S, Kleiner D, Fishbein T, Johnson L, Island E, Satoskar R, Banovec F, Jha R, Kachhela J, Feng P, Zhang T, Tesfaye A, Prins P, Loffredo CA, Mashall J, Weiner L, Atkins M, He AR Cancer Immunol Res. 2016 May;4(5):419-30. doi: 10.1158/2326-6066. CIR-15-0110. Epub 2016 Mar 11 PMID: 26968206 PMCID: 5303358

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition); Klionsky DJ,…Avantagiatti ML, et al Autophagy 2016 Jan 2; 12(1): 1-222 PMID: 26799652 PMCID: 4835977

Elevated levels of neuropeptide Y in preeclampsia: a pilot study implicating the role of stress in pathogenesis of the disease; Paiva SP, Veloso CA, Campos FF, Carniero MM, Tilan JU, Wang H, Umans JG, Zukowska Z, Kitlinska J Neuropeptides. 2016 Feb; 55:127-35. doi: 10.1016/j.npep.2015.09.006. Epub 2015 Sep 25 PMID: 26431933 PMCID: 4755897

Neuropeptide Y (NPY) in tumor gowth and suppression: Lessons learned from pediatric oncology; Tilan J, Kitlinska J Neuropeptides. 2016 Feb; 55:55-66. doi: 10.1016/j.npep.2015.10.005. Epub 2015 Oct 26. Review PMID: 26549645 PMCID: 4755837

Identification of a binding site of the human immunodeficiency virus envelope protein gp120 to neuronal specific tubulin; Avdoshina V, Taraballi F, Dedoni S, Corbo C, Paige M, Saygideger Kont Y, Uren A, Tasciotti E, Mocchetti I J Neurochem. 2016 Apr;137(2):287-98. doi: 10.1111/jnc.13557. Epub 2016 Mar 15 PMID: 26826352 PMCID: 4828312

Aldo-keto reductase 1B10 protects human colon cells from DNA damage induced by electrophilic carbonyl compounds; Zu X, Yan R, Pan J, Zhong L, Cao Y, Ma J, Cai C, Huang D, Liu J, Chung FL, Liao DF, Cao D Mol carcinog. 2017 Jan; 56(1):118-129. doi: 10.1002/mc.22477. Epub 2016 Mar 10 PMID: 26969882

Ezrin enhances EGFR signaling and modulates erlotinib sensitivity in non-small cell lung cancer; Saygideger-Kont, Minas TZ, Jones H, Hour S, Celik H, Temel I, Han J, Atabey N, Erkizan HV, Toretsky JA, Uren A Neoplasia 2016 Feb;18(2):111-20. doi: 10.1016/j.neo.2016.01.002 PMID: 26936397 PMCID: 5005263

Intact cohesion, anaphase, and chromosome segregation in human cells harboring tumor-derived mutations in STAG2; Kim JS, He X, Orr B, Wutz G, Hill V, Peters JM, Compton DA, Waldman T PLoS Genet 2016 Feb 12;12(2):e1005865. doi: 10.1371/journal.pgen.1005865. eCollection 2016 PMID: 26871722 PMCID: 4752446 

Natural endogenous human matriptase and prostasin undergo zymogen activation via independent mechanisms in an uncoupled manner; Su HC, Liang YA, Lai YJ, Chiu YL, Barndt RB, Shiao F, Chang HD, Lu DD, Huang N, Tseng CC, Wang JK, Lee MS, Johnson MD, Huang SM, Lin CY PLoS One. 2016 Dec 9; 11(12):e0167894. doi: 10.1371/journal.pone.0167894. eCollection 2016 PMID: 27936035 PMCID: 5148038

Metabolomic profiling of breast tumors using ductal fluid; Matos Do Canto L, Marian C, Varghese RS, Ahn J, Da Cunha PA, Willey S, Sidawy M, Rone JD, Cheema AK, Luta G, Nezami Ranijbar MR, Ressom HW, Haddad BR   Int J Oncol. 2016 Dec;49(6):2245-2254. doi: 10.3892/ijo.2016.3732. Epub 2016 Oct 13 PMID: 27748798 PMCID: 5117995

Endocrine response phenotypes are altered by charcoal-stripped serum variability; Sikora MJ, Johnson MD, Lee AV, Oesterreich S Endocrinology. 2016 Oct; 157(10):3760-3766. doi: 10.1210/en.2016-1297.Epub 2016 Jul 26. PMID: 27459541 PMCID: 5045515

Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane; Lai CH, Chang SC, Chen YJ, Wang YJ, Lai YJ, Chang HD, Berens EB, Johnson MD, Wang JK, Lin CY. Biol Open. 2016 Oct 15; 5(10):1380-1387. doi: 10.1242/bio.019745.  PMID: 27543057 PMCID: 5087689

Endoplasmic reticulum stress protein GRP78 modulates lipid metabolism to control drug sensitivity and antitumor immunity in breast cancer; Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Warri A, Hilakivi-Clarke L, Roberts DD, Clarke R Cancer Res. 2016 Oct 1; 76(19): 5657-5670. doi: 10.1158/0008-5472. CAN-15-2616. PMID: 27698188 PMCID: 5117832

Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer; Heckler MM, Zeleke TZ, Divekar SD, Fernandez AI, Tiek DM, Woodrick J, Darzanegan A, Roy R, Uren A, Mueller SC, Riggins RB Oncotarget. 2016 Jul 26; 7(30):47201-47220. doi: 10.18632/oncotarget.9719.  PMID: 27363015 PMCID: 5216935

Primary cancer cell culture: mammary-optimized versus conditional-reprogramming; Alamri AM, Kang K, Groeneveld S, Wang W, Zhong X, Kallakury BV, Hennighausen L, Liu X, Furth PA Endoct Relat Cancer. 2016 Jul;23(7):535-54. doi: 10.1053/ERC-16-0071. Epub 2016 Jun 7. PMID: 27267121 PMCID: 4962879

Increased matriptase zymogen activation by UV irradiation protects keratinocyte from cell death; Chen CY, Chen CJ, Lai CH, Wu BY, Lee SP, Johnson MD, Lin CY, Wang JK J Dermatol Sci. 2016 Jul; 83(1):34-44. doi: 10.1016/jdermsci.2016.03.006. Epub 2016 Mar 8. PMID: 26996264

Acquisition of estrogen independence induces TOB1-related mechanisms supporting breast cancer cell proliferation; Zhang YW, Nasto RE, Varghese R, Jablonski SA, Serebriiskii IG, Surana R, Calvert VS, Bebu I, Murray J, Jin L, Johnson M, Riggins R, Ressom H, Petricoin E, Clarke R, Golemis EA, Weiner LM Oncogene. 2016 Mar 31;35(13):1643-56. doi: 10.1038/onc.2015.226. Epub 2015 Jul 13 PMID: 26165839 PMCID: 4712124 

Analogs of the novel phytohormone, strigolactone, trigger apoptosis and synergize with PARP inhibitors by inducing DNA damage and inhibiting DNA repair; Croglio MP, Haake JM, Ryan CP, Wang VS, Lapier J, Schlarbaum JP, Dayani Y, Artuso E, Prandi C, Koltai H, Agama K, Pommier Y, Chen Y, Tricoli L, LaRocque JR, Albanese C, Yardin RI Oncotarget. 2016 Mar 22;7(12):13984-4001. doi: 10.18632/oncotarget.7414 PMID: 26910887 PMCID: 4924693