Animal Model Publications

Comprehensive Publications 2015-2017

Aggarwal M, Saxena R, Sinclair E, Fu Y, Jacobs A, Dyba M, Wang X, Cruz I, Berry D, Kallakury B, Mueller SC, Agostino SD, Blandino G, Avantaggiati ML, Chung FL (2016) Reactivation of mutant p53 by a dietary-related compound phenethyl isothiocyanate inhibits tumor growth. Cell Death Differ 23 (10): 1615-1627, doi:cdd201648 [pii];10.1038/cdd.2016.48 [doi]

Alberobello AT, Wang Y, Beerkens FJ, Conforti F, McCutcheon JN, Rao G, Raffeld M, Liu J, Rahhal R, Zhang YW, Giaccone G (2016) PI3K as a Potential Therapeutic Target in Thymic Epithelial Tumors. J Thorac Oncol 11 (8): 1345-1356, doi:S1556-0864(16)30339-2 [pii];10.1016/j.jtho.2016.04.013 [doi]

Allen M, Ghosh S, Ahern GP, Villapol S, Maguire-Zeiss KA, Conant K. Protease induced plasticity: matrix metalloproteinase-1 promotes neurostructural changes though activation of protease activated receptor 1. Sci Rep. 2016 Oct 20; (6): 35497. doi: 10.1038/srep35497. PMID: 27762280

Alothman SJ, Wang W, Goerlitz DS, Islam M, Zhong X, Kishore A, Azhar RI, Kallakury BV, Furth PA (2017) Responsiveness of Brca1 and Trp53 Deficiency-Induced Mammary Preneoplasia to Selective Estrogen Modulators versus an Aromatase Inhibitor in Mus musculus. Cancer Prev Res (Phila) 10 (4): 244-254, doi:1940-6207.CAPR-16-0268 [pii];10.1158/1940-6207.CAPR-16-0268 [doi]

AlHossiny M, Luo L, Frazier WR, Steiner N, Gusev Y, Kallakury B, Glasgow E, Creswell K, Madhavan S, Kumar R, Upadhyay G (2016). Ly6E/K Signaling to TGFβ Promotes Breast Cancer Progression, Immune Escape, and Drug Resistance. Cancer Res 76:3376-3386; doi:10.1158/0008-5472.CAN-15-2654. PMID: 27197181; PubMed Central PMCID: PMC4910623

Andrade FO, de Assis S, Jin L, Fontelles CC, Barbisan LF, Purgatto E, Hilakivi-Clarke L, Ong TP (2015) Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood. Chem Biol Interact 239 118-128, doi:S0009-2797(15)30009-0 [pii];10.1016/j.cbi.2015.06.035 [doi]

Bachis A, Forcelli P, Masliah E, Campbell L, Mocchetti I (2016a) Expression of gp120 in mice evokes anxiety behavior: Co-occurrence with increased dendritic spines and brain-derived neurotrophic factor in the amygdala. Brain Behav Immun 54 170-177, doi:S0889-1591(16)30021-6 [pii];10.1016/j.bbi.2016.01.020 [doi]

Bachis A, Wenzel E, Boelk A, Becker J, Mocchetti I (2016b) The neurotrophin receptor p75 mediates gp120-induced loss of synaptic spines in aging mice. Neurobiol Aging 46 160-168, doi:S0197-4580(16)30124-5 [pii];10.1016/j.neurobiolaging.2016.07.001 [doi]

Berens EB, Sharif GM, Schmidt MO, Yan G, Shuptrine CW, Weiner LM, Glasgow E, Riegel AT, Wellstein A (2017) Keratin-associated protein 5-5 controls cytoskeletal function and cancer cell vascular invasion. Oncogene 36 (5): 593-605, doi:onc2016234 [pii];10.1038/onc.2016.234 [doi]

Berens EB, Sharif GM, Wellstein A, Glasgow E. Testing the vascular invasive ability of cancer cells in zebrafish (Danio rerio). J Vis Exp. 2016 Nov 3;(117). doi: 10.3791/55007. PMID: 27842376

Bhatia S, Baig NA, Timofeeva O, Pasquale EB, Hirsch K, MacDonald TJ, Dritschilo A, Lee YC, Henkemeyer M, Rood B, Jung M, Wang XJ, Kool M, Rodriguez O, Albanese C, Karam SD. Knockdown of EphB1 receptor decreases medulloblastoma cell growth and migration and increases cellular radiosensitization. Oncotarget. 2015 Apr 20;6(11):8929-46. PMID: 25879388

Bhatia S, Hirsch K, Baig NA, Rodriguez O, Timofeeva O, Kavanagh K, Lee YC, Wang XJ, Albanese C, Karam SD. Effects of altered ephrin-A5 and EphA4/EphA7 expression on tumor growth in a medulloblastoma mouse model. J Hematol Oncol. 2015 Sep 7;8:105. doi: 10.1186/s13045-015-0202-9. PMID: 26345456

Bong YS, Assefnia S, Tuohy T, Neklason DW, Burt RW, Ahn J, Bueno De Mesquita PJ, Byers SW (2016) A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis. Oncotarget 7 (49): 80508-80520, doi:12768 [pii];10.18632/oncotarget.12768 [doi]

Çelik H, Bulut G, Han J, Graham GT, Minas TZ, Conn EJ, Hong SH, Pauly GT, Hayran M, Li X, Özdemirli M, Ayhan A, Rudek MA, Toretsky JA, Üren A. Ezrin Inhibition Up-regulates Stress Response Gene Expression. J Biol Chem. 2016 Jun 17; 291(25): 13257–70. doi: 10.1074/jbc.M116.718189. PMID: 27137931

Çelik H, Hong SH, Colón-López DD, Han J, Kont YS, Minas TZ, Swift M, Paige M, Glasgow E, Toretsky JA, Bosch J, Üren A. Identification of novel ezrin inhibitors targeting metastatic oesteosarcoma by screening open access malaria box. Molecular Cancer Ther. 2015 Sep 10; 14:2497-2507. doi: 10.1158/1535-7163.MCT-15-0511. PMID: 26358752; PubMed Central PMCID: PMC4636458

Clarke R, Tyson JJ, Dixon JM (2015) Endocrine resistance in breast cancer–An overview and update. Mol Cell Endocrinol 418 Pt 3 220-234, doi:S0303-7207(15)30101-5 [pii];10.1016/j.mce.2015.09.035 [doi]

Cook KL, Soto-Pantoja DR, Clarke PA, Cruz MI, Zwart A, Warri A, Hilakivi-Clarke L, Roberts DD, Clarke R (2016) Endoplasmic Reticulum Stress Protein GRP78 Modulates Lipid Metabolism to Control Drug Sensitivity and Antitumor Immunity in Breast Cancer. Cancer Res 76 (19): 5657-5670, doi:76/19/5657 [pii];10.1158/0008-5472.CAN-15-2616 [doi]

Credle JJ, George JL, Wills J, Duka V, Shah K, Lee YC, Rodriguez O, Simkins T, Winter M, Moechars D, Steckler T, Goudreau J, Finkelstein DI, Sidhu A. GSK-3β dysregulation contributes to parkinson’s-like pathophysiology with associated region-specific phosphorylation and accumulation of tau and α-synuclein. Cell Death Differ. 2015 May;22(5):838-51. doi: 10.1038/cdd.2014.179. PMID: 25394490

Czarnecka M, Trinh E, Lu C, Kuan-Celarier A, Galli S, Hong SH, Tilan JU, Talisman N, Izycka-Swieszewska E, Tsuei J, Yang C, Martin S, Horton M, Christian D, Everhart L, Maheswaran I, Kitlinska J (2015) Neuropeptide Y receptor Y5 as an inducible pro-survival factor in neuroblastoma: implications for tumor chemoresistance. Oncogene 34 (24): 3131-3143, doi:onc2014253 [pii];10.1038/onc.2014.253 [doi]

Dabydeen SA, Kang K, Diaz-Cruz ES, Alamri A, Axelrod ML, Bouker KB, Al-Kharboosh R, Clarke R, Hennighausen L, Furth PA (2015) Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance. Carcinogenesis 36 (1): 122-132, doi:bgu237 [pii];10.1093/carcin/bgu237 [doi]

DiBattista AM, Dumanis SB, Newman J, Rebeck GW (2016) Identification and modification of amyloid-independent phenotypes of APOE4 mice. Exp Neurol 280 97-105, doi:S0014-4886(16)30094-2 [pii];10.1016/j.expneurol.2016.04.014 [doi]

Fontelles CC, Guido LN, Rosim MP, Andrade FO, Jin L, Inchauspe J, Pires VC, de Castro IA, Hilakivi-Clarke L, de Assis, Ong TP (2016) Paternal programming of breast cancer risk in daughters in a rat model: opposing effects of animal- and plant-based high-fat diets. Breast Cancer Res 18 (1): 71, doi:10.1186/s13058-016-0729-x [doi];10.1186/s13058-016-0729-x [pii]

Fontelles CC, Carney E, Clarke J, Nguyen NM, Yin C, Jin L, Cruz MI, Ong TP, Hilakivi-Clarke L, de AssiS (2016) Paternal overweight is associated with increased breast cancer risk in daughters in a mouse model. Sci Rep 6 28602, doi:srep28602 [pii];10.1038/srep28602 [doi]

Fu Y, Silverstein S, McCutcheon JN, Dyba M, Nath RG, Aggarwal M, Coia H, Bai A, Pan J, Jiang J, Kallakury B, Wang H, Zhang YW, Giaccone G, He AR, Chung FL (2017) An endogenous DNA adduct as a prognostic biomarker for hepatocarcinogenesis and its prevention by Theaphenon E in mice. Hepatology, doi:10.1002/hep.29380 [doi]

Galli S, Naranjo A, Van Ryn C, Tilan JU, Trinh E, Yang C, Tsuei J, Hong SH, Wang H, Izycka-Swieszewska E, Lee YC, Rodriguez OC, Albanese C, Kitlinska J. Neuropeptide Y as a Biomarker and Therapeutic Target for Neuroblastoma. Am J Pathol. 2016 Nov;186(11):3040-3053. doi: 10.1016/j.ajpath.2016.07.019. PMID: 27743558

Gelb T, Pshenichkin S, Rodriguez OC, Hathaway HA, Grajkowska E, DiRaddo JO, Wroblewska B, Yasuda RP, Albanese C, Wolfe BB, Wroblewski JT. Metabotropic glutamate receptor 1 acts as a dependence receptor creating a requirement for glutamate to sustain the viability and growth of human melanomas. Oncogene. 2015 May 21;34(21):2711-20. doi: 10.1038/onc.2014.231. PMID: 25065592

Glazer RI (2016) PPARdelta as a Metabolic Initiator of Mammary Neoplasia and Immune Tolerance. PPAR Res 2016 3082340, doi:10.1155/2016/3082340 [doi]

Glazer RI, Kopelovich L (2017) PPARs as determinants of the estrogen receptor lineage: use of synthetic lethality for the treatment of estrogen receptor-negative breast cancer. Oncotarget 8 (31): 50337-50341, doi:10.18632/oncotarget.17302 [doi];17302 [pii]

Hilakivi-Clarke L, Warri AM, Bouker KB, Zhang X, Cook KL, Lu J, Zwart A, Nguyen N, Hu R, Cruz I, de Assis S, Wang X, Xuan J, Wang J, Wehrenberg B, Clarke R (2016) Effects of in utero exposure to ethinyl estradiol on tamoxifen resistance and breast cancer recurrence in a preclinical model. J Nat Cancer Inst 109(1).

Hong SH, Tilan JU, Galli S, Izycka-Swieszewska E, Polk T, Horton M, Mahajan A, Christian D, Jenkins S, Acree R, Connors K, Ledo P, Lu C, Lee YC, Rodriguez O, Toretsky JA, Albanese C, Kitlinska J. High neuropeptide Y release associates with Ewing sarcoma bone dissemination – in vivo model of site-specific metastases. Oncotarget. 2015 Mar 30;6(9):7151-65. PMID: 25714031

Hong SH, Tilan JU, Galli S, Acree R, Connors K, Mahajan A, Wietlisbach L, Polk T, Izycka-Swieszewska E, Lee YC, Cavalli LR, Rodriguez OC, Albanese C, Kitlinska JB. In Vivo Model for Testing Effect of Hypoxia on Tumor Metastasis. J Vis Exp. 2016 Dec 9;(118). doi: 10.3791/54532. PMID: 28060251

Hu R, Warri A, Jin L, Zwart A, Riggins RB, Fang HB, Clarke R (2015) NF-kappaB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer. Mol Cell Biol 35 (2): 379-390, doi:MCB.00847-14 [pii];10.1128/MCB.00847-14 [doi]

Kasher PR, Schertz KE, Thomas M, Jackson A, Annunziata S, Ballesta-Martinez MJ, Campeau PM, Clayton PE, Eaton JL, Granata T, Guillén-Navarro E, Hernando C, Laverriere CE, Liedén A, Villa-Marcos O, McEntagart M, Nordgren A, Pantaleoni C, Pebrel-Richard C, Sarret C, Sciacca FL, Wright R, Kerr B, Glasgow E, Banka S. Small 6q16.1 Deletions Encompassing POU3F2 Cause Susceptibility to Obesity and Variable Developmental Delay with Intellectual Disability. Am J Hum Genet. 2016 Feb 4;98(2):363-72. doi: 10.1016/j.ajhg.2015.12.014. PMID: 26833329; PubMed Central PMCID: PMC4746363

​Kim SS, Rait A, Kim E, DeMarco J, Pirollo KF, Chang EH. Encapsulation of temozolomide in a tumor-targeting nanocomplex enhances anti-cancer efficacy and reduces toxicity in a mouse model of glioblastoma. Cancer Lett. 2015 Dec 1;369(1):250-8. doi: 10.1016/j.canlet.2015.08.022. Epub 2015 Sep 2. PMID: 26325605

Kim SS, Rait A, Kim E, Pirollo KF, Chang EH. A tumor-targeting p53 nanodelivery system limits chemoresistance to temozolomide prolonging survival in a mouse model of glioblastoma multiforme. Nanomedicine. 2015 Feb;11(2):301-11. doi: 10.1016/j.nano.2014.09.005. PMID: 25240597. PMCID: PMC4330129

Lee YC, Rodriguez O, Albanese C, Santos VR, Cortes de Oliveira JA, Ferreira Donatti AL, Fernandes A; Garcia-Cairasco N, N’Gouemo P, Forcelli PA. Divergent brain changes in two audiogenic rat strains: a voxel-based morphometry and diffusion tensor imaging comparison of the Genetically Epilepsy Prone Rat (GEPR-3) and the Wistar Audiogenic Rat (WAR). Neurobiol Dis.  2017 Dec 21:111;80-90. PMID: 29274430.

Neckel ND, Dai H, Rodriguez OC. Addition of forelimb training reduces gains from robotic gait training in a rat model of spinal cord injury. IEEE Int Conf Rehabil Robot. 2017 Jul;2017:346-351. doi: 10.1109/ICORR.2017.8009271. PMID: 2881384

Nguyen N, de Oliveira Andrade F, Lu J, Zhang X, Macon M, Cruz IM, Benitez C, Wehrenberg B, Yin C, Wang X, Xuan J, de Assis S, Hilakivi-Clarke L (2017) Maternal intake of high n-6 polyunsaturated fatty acid diet during pregnancy causes transgenerational increase in mammary cancer risk in mice . Breast Cancer Res 19(1):77

Parodi DA, Greenfield M, Evans C, Chichura A, Alpaugh A, Williams J, Martin MB (2015) Alteration of mammary gland development and gene expression by in utero exposure to arsenic. Reprod Toxicol 54 66-75, doi:S0890-6238(14)00322-0 [pii];10.1016/j.reprotox.2014.12.011 [doi]

Rodriguez O, Schaefer ML, Wester B, Lee YC, Boggs N, Conner HA, Merkle AC, Fricke ST, Albanese C, Koliatsos VE. Manganese-Enhanced Magnetic Resonance Imaging as a Diagnostic and Dispositional Tool after Mild-Moderate Blast Traumatic Brain Injury. J Neurotrauma. 2016 Apr 1;33(7):662-71. doi: 10.1089/neu.2015.4002. PMID: 26414591

Schmidt MO, Garman KA, Lee YG, Zuo C, Beck PJ, Tan M, Aguilar-Pimentel JA, Ollert M, Schmidt-Weber C, Fuchs H, Gailus-Durner V, Hrabe de AM, Tassi E, Riegel AT, Wellstein A (2017) The Role of Fibroblast Growth Factor Binding Protein 1 in Skin Carcinogenesis and Inflammation. J Invest Dermatol, doi:S0022-202X(17)32825-7 [pii];10.1016/j.jid.2017.07.847 [doi]

Schwartz-Roberts JL, Cook KL, Chen C, Shajahan-Haq AN, Axelrod M, Warri A, Riggins RB, Jin L, Haddad BR, Kallakury BV, Baumann WT, Clarke R (2015) Interferon regulatory factor-1 signaling regulates the switch between autophagy and apoptosis to determine breast cancer cell fate. Cancer Res 75 (6): 1046-1055, doi:0008-5472.CAN-14-1851 [pii];10.1158/0008-5472.CAN-14-1851 [doi]

Shanmugam VK, McNish S, Duncan J, Root B, Tassi E, Wellstein A, Kallakury B, Attinger CE (2015a) Late failure of a split-thickness skin graft in the setting of homozygous factor V Leiden mutation: a case report and correlative animal model from the Wound Etiology and Healing (WE-HEAL) study. Int Wound J 12 (5): 537-544, doi:10.1111/iwj.12156 [doi]

Shanmugam VK, Tassi E, Schmidt MO, McNish S, Baker S, Attinger C, Wang H, Shara N, Wellstein A (2015b) Utility of a human-mouse xenograft model and in vivo near-infrared fluorescent imaging for studying wound healing. Int Wound J 12 (6): 699-705, doi:10.1111/iwj.12205 [doi]

Sharif GM, Schmidt MO, Yi C, Hu Z, Haddad BR, Glasgow E, Riegel AT, Wellstein A. Cell growth density modulates cancer cell vascular invasion via Hippo pathway activity and CXCR2 signaling. Oncogene. 2015 Mar 16. doi: 10.1038/onc.2015.44. PubMed PMID: 25772246; PubMed Central PMCID: PMC4573390.

Smith JP, Wang S, Nadella S, Jablonski SA, Weiner LM. Cholecystokinin receptor antagonist alters pancreatic cancer.  Cancer Immunol Immunother. 2017 Oct 17. doi: 10.1007/s00262-017-2077-9.

Spikol ED, Laverriere CE, Robnett M, Carter G, Wolfe E, Glasgow E. Zebrafish models of Prader-Willi Syndrome: Fast-track to pharmacotherapeutics. Diseases. 2016 Mar;4(1). pii: 13. doic10.3390/diseases4010013 PMID: 27857842; PubMed Central PMCID: PMC5110251

Sumis A, Cook KL, Andrade AFF, Hu R, Kidney E, Zhang X, Kim D, Carney E, Nguyen N, Yu W, Bouker KB, Cruz I, Clarke R, Hilakivi-Clarke L (2016) Social isolation induces unfolded protein response and autophagy in the mouse mammary gland: link to obesity and mammary cancer risk. Endocrine Related Cancer 10 839-856

Tilan J, Kitlinska J (2016) Neuropeptide Y (NPY) in tumor growth and progression: Lessons learned from pediatric oncology. Neuropeptides 55 55-66, doi:S0143-4179(15)00112-2 [pii];10.1016/j.npep.2015.10.005 [doi]

Timofeeva OA, Palechor-Ceron N, Li G, Yuan H, Krawczyk E, Zhong X, Liu G, Upadhyay G, Dakic A, Yu S, Fang S, Choudhury S, Zhang X, Ju A, Lee MS, Dan HC, Ji Y, Hou Y, Zheng YL, Albanese C, Rhim J, Schlegel R, Dritschilo A, Liu X (2017) Conditionally reprogrammed normal and primary tumor prostate epithelial cells: a novel patient-derived cell model for studies of human prostate cancer. Oncotarget 8 (14): 22741-22758, doi:13937 [pii];10.18632/oncotarget.13937 [doi]

Waye S, Naeem A, Choudhry MU, Parasido E, Tricoli L, Sivakumar A, Mikhaiel JP, Yenugonda V, Rodriguez OC, Karam SD, Rood BR, Avantaggiati ML, Albanese C. The p53 tumor suppressor protein protects against chemotherapeutic stress and apoptosis in human medulloblastoma cells. Aging (Albany NY). 2015 Oct;7(10):854-68. PMID: 26540407

Zhang X, Cook KL, Warri A, Cruz IM, Rosim M, Riskin J, Helferich W, Doerge D, Clarke R, Hilakivi-Clarke L (2017) Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats. Clin Cancer Res 23 (3): 814-824, doi:23/3/814 [pii];10.1158/1078-0432.CCR-16-1735 [doi]

Zhou Y, Zhao W, Al-Muhtasib N, Rebeck GW (2015) APOE Genotype Alters Immunoglobulin Subtypes in Knock-In Mice. J Alzheimers Dis 46 (2): 365-374, doi:34756043X8L15574 [pii];10.3233/JAD-142184 [doi]

Zilberberg J, Matos J, Dziopa E, Dziopa L, Yang Z, Kirk CJ, Assefnia S, Korngold R (2015) Inhibition of the Immunoproteasome Subunit LMP7 with ONX 0914 Ameliorates Graft-versus-Host Disease in an MHC-Matched Minor Histocompatibility Antigen-Disparate Murine Model. Biol Blood Marrow Transplant 21 (9): 1555-1564, doi:S1083-8791(15)00412-7 [pii];10.1016/j.bbmt.2015.06.010 [doi]