Hackensack Meridian Center for Discovery & Innovation Research Animal Facility

Key Staff/Faculty

Sundra Morrow, VT
Clinical Veterinary Services Manager
sundra.morrow@hmh-cdi.org
Office: 201-880-3534

Juanita Vakerich
Research Animal Facility Manager
Juanita.Vakerich@hmh-cdi.org
Office: 201-880-3015

Mariya Morris, DVM, DACLAM
Attending Veterinarian
mariya.morris@hmhn.org
201-880-3100

Gerardo Mendoza, DVM Clinical Veterinarian
gerardo.mendoza@hmhn.org
201-880-3100

HMH Institutional Animal Care and Use Committee (IACUC)
IACUC@hmhn.org

Leigh-Ann Tulleson
HMH IACUC Coordinator
Leigh-Ann.Tulleson@hmhn.org
201-880-3675

Overview

The Animal Models Shared Resource (AMSR) provides support and expertise to the the NCI-designated Georgetown Lombardi Comprehensive Cancer Center (LCCC) Research Consortium. Within this Consortium, the AMSR provides comprehensive support to researchers at both the LCCC in Washington, DC, and the John Theurer Cancer Center in New Jersey, which includes research at the Hackensack Meridian Center for Discovery and Innovation (CDI). The CDI Research Animal Facility (CDI RAF) is a newly renovated ~40,000 sq. ft. state-of-the-art complex occupying the entire 3-6th floors of the Hackensack-Seton Hall Medical School Annex building, which is physically linked to the CDI. The CDI RAF received full AAALAC International accreditation on March 5, 2020. The CDI RAF has extensive capacity for rodents (>10,000 animals; mice, rats and guinea pigs) and rabbits (60 in ABSL3) all housed in individual ventilated caging (IVC) units and handled under sterile conditions. A full-time staff supports the facility, including a RAF manager, and experienced animal care technicians trained with all housed species and capable of performing routine animal manipulations. Routine veterinary oversight occurs onsite. The ABSL2/ABSL3 RAF is dedicated to pharmacokinetics in uninfected and infected animals and pathogen-based efficacy studies. The facility consists of multiple rodent housing rooms, a rabbit housing room with custom-designed biosafety enclosures, tissue culture labs, procedure rooms, and dedicated rooms for aerosol challenge of mice, rats, guinea pigs and rabbits. Metabolic mouse cages are available for in depth pharmacokinetic, metabolism and elimination studies. Infected animals are housed in micro-isolator cages within this ABSL3 facility. A Full Body Inhalation Exposure System (Glascol) placed inside a safety flow hood is available to uniformly infect up to 100 mice per run with aerosolized pathogen inoculum. A rabbit aerosol infection system is also set up in a safety flow hood.  There are several small animal operating and procedure rooms within the facility.

The HMH Institutional Animal Care and Use Committee (IACUC) oversees the CDI RAF facility. The facility also contains a dedicated floor for ABSL3 rodent and small animal studies. The facility was designed according to the latest CDC Biosafety in Microbiological and Biomedical Laboratories (BMBL) 5th edition guidelines. All biocontainment-related studies are approved by the HMH IACUC and IBC. The CDI RAF maintains 24/7/365 security. Only qualified users, as determined by the Institutional Biosafety Committee (IBC) according to the latest federal guidelines may enter the ABSL-3 RAF. Electronic door locks with pass-card access at the entrances of the ABSL3 to maintain a computerized log of all people entering the facility. In addition, 24 hour video surveillance cameras with tape back-up are operational at the ABSL-3 entrance.

Instruments available at CDI RAF include:

  • VisualSonics VEVO 3100 Small Animal Ultrasound Imaging System
  • Perkin Elmer IVIS X5 multimode imaging system (Xray, bioluminescence, fluorescence and isotopes)
  • Rad source X-ray irradiator  

Location

Center for Discovery and Innovation – 123 Metro Boulevard, Nutley, NJ 07110

  • Building 123A