On January 11, we welcome Tom Misteli, PhD, as our Grand Rounds speaker. Tom is Director, Center for Cancer Research and the Laboratory of Receptor Biology and Gene Expression at the NCI, and is a NIH Distinguished Investigator where he is Head, Cell Biology of Genomes Group. I came to know Tom during my tenure on the Board of Scientific Counselors for Clinical Sciences and Epidemiology, and found him to be an engaging and highly effective leader and communicator.
Tom is an internationally renowned cell biologist who pioneered the use of imaging approaches to study genomes and gene expression. His laboratory uses cell biological, molecular, biochemical and imaging approaches to uncover fundamental principles of genome architecture and to apply this knowledge. Defects in genome organization and nuclear architecture are responsible for numerous human diseases including cancer, neurodegenerative disorders, and muscular dystrophies and they have been linked to human aging. Tom uses several differentiation and disease models to elucidate how genome organization contributes to physiological processes and disease, particularly in cancer and aging.
Tom trained at the University of London, UK, and the Cold Spring Harbor Laboratory, NY, where he initiated the use of imaging approaches to study genomes in living cells. He has received numerous awards including the Gian Tondury Award, the Gold Medal of The Charles University, the 2012 Flemming Award, The Wilhem Bernhard Medal and the Herman Beerman Award.
Representative publications include:
- Repression of the Antioxidant NRF2 Pathway in Premature Aging. Kubben N, Zhang W, Wang L, Voss TC, Yang J, Qu J, Liu GH, Misteli T. Cell. 165: 1361-1374, 2016.
- Identification of gene positioning factors using high-throughput imaging mapping. Shachar S, Voss TC, Pegoraro G, Sciascia N, Misteli T. Cell. 162(4): 911-23, 2015.
- Spatial dynamics of chromosome translocations in living cells. Roukos V, Voss TC, Schmidt CK, Lee S, Wangsa D, Misteli T. Science. 341: 660-4, 2013.
- Regulation of alternative splicing by histone modifications. Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T. Science. 327: 996-1000, 2010.
- Lamin A-dependent nuclear defects in human aging. Scaffidi P, Misteli T. Science. 312: 1059-63, 2006.
I look forward to seeing you at his Grand Rounds.
Louis M. Weiner, MD
Director, Georgetown Lombardi
Chair, Department of Oncology
Associate Vice President, GUMC
Clinical Director of Cancer Services, GUH
Director, MedStar Georgetown Cancer Institute