The mission of the informatics group is to provide translation research tools that can aid scientists as well as clinicians in their efforts at GUMC.
Subha Madhavan, PhD - Principal Investigator
Dr. Madhavan is the director of Clinical Research Informatics at Georgetown Lombardi Comprehensive Cancer Center. She is an information scientist who has worked in the field of biomedical informatics and clinical data management and analysis for the past 11 years.
Prior to joining Georgetown Dr. Madhavan served as the associate director of Product and Program Management in the Life sciences informatics area at NCI's Center for Biomedical Informatics and Information technology (CBIIT) where she led the development of several bioinformatics programs including the Cancer Genome Atlas (TCGA) project and the platform supporting the REMBRANDT project, which received the Service to America Medal in 2005. Her work at NCI involved bridging the gap between bench and bedside by enabling researchers and physician scientists to use cutting edge biomedical informatics solutions to identify better therapies for cancer. Dr. Madhavan's leadership and program management skills were recognized by her selection to the prestigious SEED (Senior Enrichment and Executive Development) leadership program by the NCI leadership in 2007.
Dr. Madhavan holds a doctorate in molecular biology from the Uniformed Services University for Health Sciences, as well as a master's degree in computer information systems from the University of Maryland. Her current interests include international science, leading multi-disciplinary teams in science to enhance the delivery aspect of translational research with the ultimate goal of making cura personalis - personalized medicine a reality. In her spare time, Subha likes to cook and enjoys classical Indian dance and music.
Michael Harris, MA - Technical Lead
Michael Harris has over 20 years of software development experience and is an experienced technical leader and enterprise software architect, specializing in n-tier web application development leveraging the Java programming language. Mr. Harris has significant experience in J2EE life-cycle software implementations for platform-independent, fully integrated online systems. Mr. Harris designed and developed data portals for the translational informatics platform caIntegrator, Target (childhood cancer effort lead by NCI and Children's Oncology Group) and the cancer genome atlas project that involved integrating modules for data analysis such as with GenePattern, and algorithms supporting higher-order data analysis leveraging the R programming language at the NCI, center for biomedical Informatics and Information technology. He is very familiar with caBIG technologies and has worked on adopting and adapting caBIG technologies such as caCore software development kit, caDSR (metadata repository) and EVS (Enterprise vocabulary server) for over 3 years. Mr. Harris's leadership skills, technical and bioinformatics skills will provide added value to the ISC effort at Georgetown and ensure that systems are delivered on time with robust functionality. Above all, Mr. Harris is well-experienced in talking with end users of systems and eliciting the right requirements and implementing them based with continued iterative user engagement.
Yuriy Gusev, PhD â€“ Senior Bioinformatics Scientist
Dr. Gusev has more than 15 years of experience in academic and industry research in the fields of cancer research, biomarker discovery, bioinformatics, systems biology and computational modeling of biological systems. He has nearly 50 peer -reviewed publications including a book, book chapters and journal articles in the areas of microRNA , gene and protein expression profiling in cancer, quantitative analysis and computer modeling of cancer progression and chromosomal instability. He has been a junior faculty at the Johns Hopkins School of Medicine where he has developed novel methodologies for quantitative analysis of cancer biomarkers for breast, pancreatic, liver, prostate and thyroid cancers. As an assistant professor at University of Oklahoma he has been a director of bioinformatics core and has been working on multiple NIH funded projects involved computational analysis of microRNA and mRNA profiling in breast, pancreatic and liver tumor samples, cell lines and animal models and has developed a novel systems biology methodology for functional profiling of co-expressed microRNAs in human cancers. He is utilizing his bioinformatics and biostatistics analysis expertise as a lead of analytical team for developing of standard omics data analysis and integration workflows for G-DOC®, caBIG ISCRE and NCI CCSB projects.
David Tanenbaum, PhD - Delivery Manager
Dr. Tanenbaum is a scientific professional with over 10 years of experience in a wide array of subject areas (e.g., x-ray crystallography, genetics, genomics, bioinformatics, proteomics). He was a project manager and scientist at J. Craig Venter Institute, with a focus on metagenomics sequence analysis. His work there included portions the institute's ongoing Global Ocean Sampling program which is uncovering new genes and protein families from organisms found in sea water from across the globe, as well as several related projects such as the Australian Soil Project and the Dental Microbiome. He also managed several key projects during his six years at Celera, including the $30 million Applera SNP Project and a Psoriasis GWAS study, and was a major contributor to the Cancer Proteomics Program. Dr. Tanenbaum has a B.A. in Chemistry from the University of Virginia, a Ph.D. in Molecular Biophysics and Biochemistry from Yale University, and postdoctoral training from Harvard Medical School. He is well-published in the literature, including in Science, Nature, Nature Genetics, PNAS, and Nature Biotechnology. More information can be obtained at http://www.linkedin.com/in/davidmtanenbaum
Baris Suzek, MS - Metadata Lead
Mr. Suzek has over ten years of experience in open source software development, specializing in biomedical informatics. Since 2001 he has been a key member of the Protein Information Resource (PIR) at Georgetown University, where he has been intimately involved in both scientific and management aspects of the project. Mr. Suzek has served as a database administrator, system administrator, and algorithm developer and associate team lead. More recently, he has been heavily involved in caBIG related activities, including acting as a guide to mentor and oversee developments within the caBIG Integrative Cancer Research (ICR) Workspace. He has also led caBIG silver level compatibility reviews and participated in the development of caBIG Common Data Element (CDE) standards. Mr. Suzek is also experienced with software architecture as he has developed applications following the principles of Model Driven Architecture (MDA), service-oriented architecture, n-tier architecture and common API. Finally, he is an experienced programmer with languages such as Awk, C, Java, Perl, and SQL; database tools including Oracle; operating systems including RedHat, UNIX, Solaris, and Windows; and technologies such as J2EE, JSP, XML, XSL, and UML. Relevant to the ISC is his participation in the development of caBIG CDE Standards for family registry data elements including the CDE for "Family Member Relationship". Several use cases including one from Cancer research center of Hawaii, a C-CFR site have been used in development of the standard. Mr. Suzek is the recipient of caBIG Outstanding Achievement Award 2008 in recognition of his significant accomplishments and contributions to caBIG program.
Dongkyu Kim, PhD - DBA/ETL Analyst
Dr. Kim is a staff researcher and database lead in the Imaging Science and Information Systems (ISIS) Center at Georgetown. He received BS, MS, and PhD degrees in computer science from Seoul National University, where his research focus was on database development, semantic models, and ontologies. Dr. Kim worked in private industry in Korea for five years as a project manager and technical lead, where he developed a number of database systems for medical and other applications. He joined Georgetown University last year to serve as a database lead and DBA for our biomedical informatics projects and is currently the lead technical expert for a project to port some of the Georgetown shared resources from Access databases to a SQL platform. His experience includes programming languages such as Java, Perl, and C++; databases including Oracle, SQLServer, MySQL, and PostgreSQL; platforms including Unix, Linux, Windows, and DOS; and technologies such as J2EE, WebSphere, JSP, XML, MXL, UMLS, SAS, and ETL studio. He will perform data modeling and database administration tasks for the BC-CFR ISC.
Andrew Shinohara, MS - Programmer
Mr. Shinohara is an accomplished software engineer with many years of experience in the bioinformatics domain. He holds his MS in Bioinformatics from The Johns Hopkins University and his BS in Molecular and Cellular Biology from The University of Arizona. He has worked on multiple caBIG efforts such as caIntegrator, NCIA and caBIO, providing software design and development resources, as well as quality assurance and testing. He also worked on the BioHealthBase application for the NIAID where he worked on highly interactive visualizations of genomic data, providing a superior user experience and a high level of interactivity. Mr. Shinohara enjoys the engineering challenges that come from working with high-throughput datasets and applying cutting edge technologies to meet those challenges.
Kevin Rosso, MS - Programmer
Mr. Rosso has over 7 years in the software design and development arena. He currently holds an MS in Information Systems and Technology from The Johns Hopkins University and a BS in Business Marketing from Mount St. Mary's University. This diversity has helped him excel in user experience design at the marketing level and full life-cycle software development at a technological level. He has been a key developer on caBIG projects such as caIntegrator in the bioinformatics realm, and a technical lead in the development of biometric search software used by the Department of Homeland Security. Mr. Rosso enjoys the creativity involved in software design as a means for scientists and researchers to best analyze and interpret complex data.
Krithika Bhuvaneshwar, MS - Biostatistician
Ms. Bhuvaneshwar combines her interdisciplinary skills in bioinformatics and data analysis in the integration of data for the G-DOC framework at Georgetown University. She holds a Master's degree in Biomedical Engineering from Louisiana Tech University. She is experienced in data mining & machine learning techniques, bioinformatics and in statistical tools like R. Krithika has worked on projects related to time series and proteomics data using MATLAB, BioJava and Java. She is also skilled in SQL, Oracle database and IBM Webshpere eCommerce through her previous experience at Infosys Technologies Ltd. Her personal interests include listening to music, singing, reading and writing.
Robinder Gauba, MS - Biostatistician
Mr. Gauba is a well rounded statistical and bioinformatics analyst with many years of experience in the realm of bioinformatics, biostatistics and biotechnology. He holds his master's degree in Bioinformatics from Georgetown University & Biotechnology from Goa University in India. He has worked with Genomic Medicine Department of J. Craig Venter Institute to perform statistical and computational analysis and to develop novel methodology for visualizing integrated knowledge based genome-wide protein-protein interaction networks of different bacterial species. He is currently involved in G-DOC® and caBIG In Silico research projects with major focus on development of novel infrastructure for integrative analysis pipeline, visualization of multidimensional datasets & data reduction methods to better understand human cancers and the mechanisms underlying them. Mr. Gauba relish challenges involved in the field of clinical research informatics, predictive analytics, interactomics and visual computing.