Histopathology and Tissue Shared Resource

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Molecular Pathology Laboratory (MPL)

The MPL interacts closely with the Human Tissue Bank to provide sectioned blocks and provide services for research.

The MPL services include:

  • Routine services for:

    • Tissue fixation and processing.

    • Paraffin block sectioning.

    • Frozen block sectioning.

    • Tissue staining.

    • Tissue sectioning
    Tissue Sectioning

 

  • Customized services to meet particular research goals.
  • Consultation and advice for fixation and tissue preparation to help meet research goals.

  • The Resource operates a "Tissue Arrayer" to make tissue micro array (TMA).

    • The process creates paraffin blocks with up to 200 to 600 cores of tissue embedded in a single block.

    • TMAs can be used for large numbers of patients (or animals) on one slide for profiling cancer, normal tissues, and other applications.

    • Enhance our capability to ask tissue-related questions simply at a substantially reduced cost, and compare large numbers of samples side-by-side on the same slide.

    • Applications for screening for:

      • Protein expression--IHC, immunofluorescence

      • In situ hybridization

      • FISH