Flow Cytometry and Cell Sorting

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2003 2004 2005 2006 2007 2008

2003

Ahonen, T. J., J. Xie, M. J. LeBaron, J. Zhu, M. Nurmi, K. Alanen, H. Rui, and M. T. Nevalainen. 2003. Inhibition of Transcription Factor Stat5 Induces Cell Death of Human Prostate Cancer Cells. J.Biol.Chem. 278:27287-27292.

Kozikowski, A. P., W. Tuckmantel, G. Bottcher, and L. J. Romanczyk, Jr. 2003. Studies in polyphenol chemistry and bioactivity. 4.(1) Synthesis of trimeric, tetrameric, pentameric, and higher oligomeric epicatechin-derived procyanidins having all-4beta,8-interflavan connectivity and their inhibition of cancer cell growth through cell cycle arrest. J Org.Chem 68:1641-1658.

Luo, X. Y., X. Q. Gong, and C. K. Tang. 2003. Suppression of EGFRvIII-mediated proliferation and tumorigenesis of breast cancer cells by ribozyme. Int.J.Cancer 104:716-721.

Mateo-Lozano, S., O. M. Tirado, and V. Notario. 2003. Rapamycin induces the fusion-type independent down-regulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation. Oncogene 22:9281-9286.

Ojeifo, J. O., A. G. Wu, H. B. Herscowitz, and K. R. Meehan. 2003. Phenotypic and Immunologic Characteristics of Cocetaxel-Mobilized Peripheral Blood Stem Cells in Mice. J Hematother.Stem Cell Res. 12:189-197.

Rait, A., K. F. Pirollo, D. Ulick, K. J. Cullen, and E. H. Chang. 2003. Her-2 Targeted Antisense Oligonucleotides Result in Sensitization of Head and Neck Cancer Cells to chemotherapeutic Agent. Ann.N.Y.Acad.Sci. 1002:1-12.

Stoica, G. E., T. F. Franke, A. Wellstein, E. Morgan, F. Czubayko, H. J. List, R. Reiter, M. B. Martin, and A. Stoica. 2003. Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway. Oncogene 22:2073-2087.

Stoica, G. E., T. F. Franke, A. Wellstein, E. Morgan, F. Czubayko, H.-J. List, R. Reiter, M. B. Martin, and A. Stoica. 2003. The Effect of Estradiol on Estrogen Receptor-a Gene Expression and Activity Can be Modulated by Akt. Oncogene 22:7998-8011.

Zhang, M., R. Guo, Y. Zhai, X. Y. Fu, and D. Yang. 2003. Light stimulates IFNgamma-mediated intercellular adhesion molecule-1 upregulation of cancer cells. Hum Immunol. 64:416-426.

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2004

Bateman, N. W., D. Tan, R. G. Pestell, J. D. Black, and A. R. Black. 2004. Intestinal tumor progression┬ ┬ ┬ ┬ ┬ is associated with altered function of KLF5. J.Biol.Chem. 279:12093-12101.

Broustas, C. G., P. C. Gokhale, A. Rahman, A. Dritschilo, I. Ahmad, and U. Kasid. 2004. BRCC2, a novel BH3-like domain-containing protein, induces apoptosis in a caspase-dependent manner. J Biol Chem 279:26780-26788.

D'Amico, M., K. Wu, M. Fu, M. Rao, C. Albanese, R. G. Russell, H. Lian, D. Bregman, M. A. White, and R. G. Pestell. 2004. The inhibitor of cyclin-dependent kinase 4a/alternative reading frame (INK4a/ARF) locus encoded proteins p16INK4a and p19ARF repress cyclin D1 transcription through distinct cis elements. Cancer Research 64:4122-4130.

Han, S., L. A. Espinoza, H. Liao, A. H. Boulares, and M. E. Smulson. 2004. Protection by antioxidants against toxicity and apoptosis induced by the sulphur mustard analog 2-chloroethylethyl sulphide (CEES) in Jurkat T cells and normal human lymphochytes. British Journal of Pharmacology 142:229.

Isenberg, J. S., S. Vinod-Kumar, G. White, and J. O. Ojeifo. 2004. Hematopoietic stem cells mobilization and immune response in tumor-bearing mice. Ann Plast.Surg 52:523-530.

Koehler, N. K. U., Yang, C-Y., Varady, J., Lu, Y., Wu, X-W., Liu, M., Yin, D., Bartels, M., Xu, B-Y., Roller, P. P., Long, Y-Q., Li, P., Kattah, M., Moran, K., Tilley, E., Richert, J. R., and Wang, S. 2004.┬ Structure-based discovery of non-peptide small molecules to block the T cell response to myelin basic protein. Journal of Medicinal Chemistry 47:4989-97.

Koehler, N. K. U., Yang, C-Y., Varady, J., Lu, Y., Wu, X-W., Liu, M., Yin, D., Bartels, M., Xu, B-Y., Roller, P. P., Long, Y-Q., Li, P., Kattah, M., Moran, K., Tilley, E., Richert, J. R., and Wang, S. Structure-based discovery of non-peptide small molecules to block the T cell response to myelin basic protein. Journal of Medicinal Chemistry . 2004. Zhang, L., S. Yoo, A. Dritschilo, I. Belyaev, and V. Soldatenkov. 2004. Targeting Ku protein for sensitizing of breast cancer cells to DNA-damage. Int J Mol Med 14:153-159.

Kumar, D., P. C. Gokhale, C. Broustas, D. Chakravarty, I. Ahmad, and U. N. Kasid. 2004. Expression of SCC-32, an anti-apoptotic molecule, correlates with enhanced proliferation and tumorigenicity of MDA-MB435 cells. Oncogene 23:612-616.

Laguinge, L. M., S. Lin, R. N. Samara, A. N. Salesiotis, and J. M. Jessup. 2004. Nitrosative stress in rotated three-dimensional colorectal carcinoma cell cultures induces microtubule depolymerization and apoptosis. Cancer Res 64:2643-2648.

Lee, C., Kim J. and Waldman, T. 2004. PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells.┬ Cancer Research 64:6906-6914.

Liu, N., X. M. Xu, J. Chen, L. Wang, S. Yang, C. B. Underhill, and L. Zhang. 2004. Hyaluronan-binding peptide can inhibit tumor growth by interacting with Bcl-2. Int J Cancer 109:49-57.

Moroni, M., Soldatenkov, V., Zhang, L., Zhang, Y., Stoica, G., Gehan, E., Rashidi, B., Singh, M., Ozdemirli, M., and Mueller, S. C. 2004. Progressive Loss of Syk and Abnormal Proliferation in Breast Cancer Cells. Cancer Research 64 :7346-54.

Pack, S., Alper, O., Stromberg, K., Augustus, M., Ozdemirli, M., Miermont, A., Klus, G., Rusin, M., Slack, R., Hacker, N.F.,┬ Ried, T., Szallasi, Z., and O. Alper.┬ 2004. Simultaneous Suppression of Epidermal Growth Factor Receptor and c-erbB-2 Reverses Aneuploidy and Malignant Phenotype of a Human Ovarian Carcinoma Cell Line.┬ Cancer Research 64:789-94, 2004.

Pradeep, A., C. Sharma, P. Sathyanarayana, C. Albanese, J. V. Fleming, T. C. Wang, M. M. Wolfe, K. M. Baker, R. G. Pestell, and B. Rana. 2004. Gastrin mediated activation of cyclin D1 transcription involves beta-catenin and CREB pathways in gastric cancer cells. Oncogene 23:3689-3699.

Soldatenkov, V. A. and V. Potaman. 2004. DNA-binding properties of poly(ADP-ribose) polymerase: a target for anti-cancer therapy. Current Drug Targets. Current Drug Targets 5:357-365.

Williams, T. M., H. Lee, M. W. Cheung, A. W. Cohen, B. Razani, P. Iyengar, P. E. Scherer, R. G. Pestell, and M. P. Lisanti. 2004. Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia. J Biol Chem 279:24745-24756.

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2005

Camara, J. E., A. M. Breier, T. Brendler, S. Austin, N. R. Cozzarelli, and E. Crooke. 2005. Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication. EMBO Rep. 6:736-741.

Bae, I., J. K. Rih, H. J. Kim, H. J. Kang, B. Haddad, A. Kirilyuk, S. Fan, M. L. Avantaggiati, and E. M. Rosen. 2005. BRCA1 Regulates Gene Expression for Orderly Mitotic Progression. Cell Cycle 4.

Bouker, K. B., T. C. Skaar, R. B. Riggins, D. S. Harburger, D. R. Fernandez, A. Zwart, A. Wang, and R. Clarke. 2005. Interferon regulatory factor-1 (IRF-1) exhibits tumor suppressor activities in breast cancer associated with caspase activation and induction of apoptosis. Carcinogenesis 26:1527-1535.

Boulares, H., A. G. Yakovlev, and M. E. Smulson. 2005. PARP-1 mediated regulation of apoptotic endonuclease DNAS1L3. In Poly(ADP-Ribosyl)ation. Molecular Biology Intelligence Unit. A. B├╝rkle, ed. Landes Bioscience, Georgetown, TX, USA.

Bouras, T., M. Fu, A. A. Sauve, F. Wang, A. A. Quong, N. D. Perkins, R. T. Hay, W. Gu, and R. G. Pestell. 2005. SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem 280:10264-10276.

Cairo, M. S., E. L. Wagner, J. Fraser, G. Cohen, d. van, V, S. L. Carter, N. A. Kernan, and J. Kurtzberg. 2005. Characterization of banked umbilical cord blood hematopoietic progenitor cells and lymphocyte subsets and correlation with ethnicity, birth weight, sex, and type of delivery: a Cord Blood Transplantation (COBLT) Study report. Transfusion 45:856-866.

Camara, J. E., A. M. Breier, T. Brendler, S. Austin, N. R. Cozzarelli, and E. Crooke. 2005. Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication. EMBO Rep. 6:736-741.

Chen, J., X. M. Xu, C. B. Underhill, S. Yang, L. Wang, Y. Chen, S. Hong, K. Creswell, and L. Zhang. 2005. Tachyplesin activates the classic complement pathway to kill tumor cells. Cancer Res 65:4614-4622.

Chen, T., Y. Pengetnze, and C. C. Taylor. 2005. Src inhibition enhances paclitaxel cytotoxicity in ovarian cancer cells by caspase-9-independent activation of caspase-3. Mol.Cancer Ther. 4:217-224

Chepko, G., R. Slack, D. Carbott, S. Khan, L. Steadman, and R. B. Dickson. 2005. Differential alteration of stem and other cell populations in ducts and lobules of TGFalpha and c-Myc transgenic mouse mammary epithelium. Tissue Cell 37:393-412.

Chiba-Falek, O., J. A. Kowalak, M. E. Smulson, and R. L. Nussbaum. 2005. Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene. Am J Hum Genet 76:478-492.

Disbrow GL, Baege AC, Kierpiec KA, Yuan H, Centeno JA, Thibodeaux CA, Hartmann D, Schlegel R. Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. Cancer Res. 2005 Dec 1;65(23):10854-61.

Espinoza, L. A., M. Valikhani, M. J. Cossio, T. Carr, M. Jung, J. Hyde, M. L. Witten, and M. E. Smulson. 2005. Altered expression of gamma-synuclein and detoxification-related genes in lungs of rats exposed to JP-8. Am J Respir.Cell Mol.Biol 32:192-200.

Fu, M., C. Wang, M. Rao, X. Wu, T. Bouras, X. Zhang, Z. Li, X. Jiao, J. Yang, A. Li, N. D. Perkins, B. Thimmapaya, A. L. Kung, A. Munoz, A. Giordano, M. P. Lisanti, and R. G. Pestell. 2005. Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J Biol Chem 280:29728-29742.

Fu, M., M. Rao, T. Bouras, C. Wang, K. Wu, X. Zhang, Z. Li, T. P. Yao, and R. G. Pestell. 2005. Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem 280:16934-16941.

Laguinge, L., O. Bajenova, E. Bowden, J. Sayyah, P. Thomas, and H. Juhl. 2005. Surface expression and CEA binding of hnRNP M4 protein in HT29 colon cancer cells. Anticancer Res 25:23-31.

Mayer, F., S. Mueller, E. Malenke, M. Kuczyk, J. T. Hartmann, and C. Bokemeyer. 2005. Induction of apoptosis by flavopiridol unrelated to cell cycle arrest in germ cell tumour derived cell lines. Invest New Drugs 23:205-211.

Riggins, R. B., A. Zwart, R. Nehra, and R. Clarke. 2005. The nuclear factor kappa B inhibitor parthenolide restores ICI 182,780 (Faslodex; fulvestrant)-induced apoptosis in antiestrogen-resistant breast cancer cells. Mol.Cancer Ther. 4:33-41.

Simbulan-Rosenthal CM, Trabosh V, Velarde A, Chou FP, Daher A, Tenzin F, Tokino T, Rosenthal DS. Id2 protein is selectively upregulated by UVB in primary, but not in immortalized human keratinocytes and inhibits differentiation. Oncogene. 2005 Aug 18;24(35):5443-58.

Stoica, B. A., V. A. Movsesyan, S. M. Knoblach, and A. I. Faden. 2005. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol.Cell Neurosci. 29:355-371.

Suy, S., J. B. Mitchell, A. Samuni, S. Mueller, and U. Kasid. 2005. Nitroxide tempo, a small molecule, induces apoptosis in prostate carcinoma cells and suppresses tumor growth in athymic mice. Cancer 103:1302-1313.

Tirado, O. M., S. Mateo-Lozano, and V. Notario. 2005. Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax : Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity. Oncogene 24:3348-3357.

Tirado OM, Mateo-Lozano S, Notario V. Roscovitine is an effective inducer of apoptosis of Ewing's sarcoma family tumor cells in vitro and in vivo. Cancer Res. 2005 Oct 15;65(20):9320-7.

Wu, K., M. D'Amico, C. Wang, C. Albanese, R. G. Pestell, and S. Mani. 2005. A study of cytotoxic synergy of UCN-01 and flavopiridol in syngeneic pair of cell lines. Invest New Drugs 23:299-309.

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2006

Chinnasamy, D., M. D. Milsom, J. Shaffer, J. Neuenfeldt, A. F. Shaaban, G. P. Margison, L. J. Fairbairn, and N. Chinnasamy. 2006. Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI. Virol.J┬ 3:14.

Han W, Zhang T, Yu H, Foulke JG, Tang CK.2006. Hypophosphorylation of residue Y1045 leads to defective downregulation of EGFRvIII.┬ Cancer Biol Ther. 2006 Oct;5(10):1361-8. Epub 2006 Oct 26.

Kim, J.S., Lee, C., Bonifant, C.L., Ressom, H. and T. Waldman.┬ 2006.┬ Activation of p53-Dependent Growth Suppression in Human Cells by Mutations in PTEN or PIK3CA. Mol Cell Biol Oct 23;

Mateo-Lozano S, Gokhale PC, Soldatenkov VA, Dritschilo A, Tirado OM, Notario V. Combined transcriptional and translational targeting of EWS/FLI-1 in Ewing's sarcoma. Clin Cancer Res. 2006 Nov 15;12(22):6781-90.

Simbulan-Rosenthal CM, Daher A, Trabosh V, Chen WC, Gerstel D, Soeda E, Rosenthal DS. Id3 induces a caspase-3- and -9-dependent apoptosis and mediates UVB sensitization of HPV16 E6/7 immortalized human keratinocytes. Ocogene. 2006 Jun 22;25(26):3649-60. Epub 2006 Jan 30.

Sobel, D. O. and K. Creswell. 2006. Characterization of anti-islet cytotoxic human T-cell clones from patients with type 1 diabetes mellitus. Autoimmunity 39:323-332.

VandenBussche, C. J., S. Dakshanamurthy, P. E. Posch, and C. K. Hurley. 2006. A single polymorphism disrupts the killer Ig-like receptor 2DL2/2DL3 D1 domain. J Immunol. 177:5347-5357.

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2007

Boudreau HE, Broustas CG, Gokhale PC, Kumar D, Mewani RR, Rone JD, Haddad BR, Kasid U.┬ Expression of BRCC3, a novel cell cycle regulated molecule, is associated with increased phospho-ERK and cell proliferation.┬ Int J Mol Med. 2007 Jan;19(1):29-39.

Casimiro M, Rodriguez O, Pootrakul L, Aventian M, Lushina N, Cromelin C, Ferzli G, Johnson K, Fricke S, Diba F, Kallakury B, Ohanyerenwa C, Chen M, Ostrowski M, Hung MC, Rabbani SA, Datar R, Cote R, Pestell R, Albanese C.┬ ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo.┬ Cancer Res. 2007 May 1;67(9):4364-72.

Cha H, Wang X, Li H, Fornace AJ Jr.┬ A functional role for p38 MAPK in modulating mitotic transit in the absence of stress.┬ J Biol Chem. 2007 Aug 3;282(31):22984-92.

Gomez BP, Riggins RB, Shajahan AN, Klimach U, Wang A, Crawford AC, Zhu Y, Zwart A, Wang M, Clarke R.┬ Human X-box binding protein-1 confers both estrogen independence and antiestrogen resistance in breast cancer cell lines.┬ FASEB J. 2007 Dec;21(14):4013-27.

Kim JS, Lee C, Bonifant CL, Ressom H, Waldman T.┬ Activation of p53-dependent growth suppression in human cells by mutations in PTEN or PIK3CA.┬ Mol Cell Biol. 2007 Jan;27(2):662-77.

Lahusen T, Fereshteh M, Oh A, Wellstein A, Riegel AT.┬ Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer 1.┬ Cancer Res. 2007 Aug 1;67(15):7256-65.

Lee C, Kim JS, Waldman T.┬ Activated PI3K signaling as an endogenous inducer of p53 in human cancer.┬ Cell Cycle. 2007 Feb 1;6(4):394-6.

Lee SA, Jung M.┬ The nucleoside analog sangivamycin induces apoptotic cell death in breast carcinoma MCF7/adriamycin-resistant cells via protein kinase Cdelta and JNK activation.┬ J Biol Chem. 2007 May 18;282(20):15271-83.

Nam DH, Ramachandran S, Song DK, Kwon KY, Jeon DS, Shin SJ, Kwon SH, Cha SD, Bae I, Cho CH.┬ Growth inhibition and apoptosis induced in human leiomyoma cells by treatment with the PPAR gamma ligand ciglitizone.┬ Mol Hum Reprod. 2007 Nov;13(11):829-36.

Samara RN, Laguinge LM, Jessup JM. Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling.Cancer Res. 2007 May 15;67(10):4774-82.

Tassi E, Walter S, Aigner A, Cabal-Manzano RH, Ray R, Reier PJ, Wellstein A.┬ Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury.┬ Am J Physiol Regul Integr Comp Physiol. 2007 Aug;293(2):R775-83.

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2008

Foshay KM, Gallicano GI. Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate. Stem Cells Dev. 2008 Apr;17(2): 269-78.

Laguinge LM, Samara RN, Wang W, El-Deiry WS, Corner G, Augenlicht L, Mishra L, Jessup JM.DR5 receptor mediates anoikis in human colorectal carcinoma cell lines. Cancer Res. 2008 Feb 1;68(3):909-17.

Li H, Armando I, Yu P, Escano C, Mueller SC, Asico L, Pascua A, Lu Q, Wang X, Villar VA, Jones JE, Wang Z, Periasamy A, Lau YS, Soares-da-Silva P, Creswell K, Guillemette G, SibleyDR, Eisner G, Gildea JJ, Felder RA, and Jose PA.┬ Dopamine 5 receptor mediates Ang II type 1 receptor degradation via a ubiquitin-proteasome pathway in mice and human cells. J Clin Invest. 118(6):2180-9, 2008.

Matsumoto H, Hirata K, Sakamaki N, Hagino K, Ushiyama H. Musashi1 modulates mammary progenitor cell expansion through proliferin-mediated activation of the Wnt and Notch pathways.Mol Cell Biol. 2008 Jun;28(11):3589-99.

Solomon DA, Kim JS, Jenkins S, Ressom H, Huang M, Coppa N, Mabanta L, Bigner D, Yan H, Jean W, Waldman T. Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. ancer Res. 2008 Apr 15;68(8):2564-9. Epub 2008 Apr 1.

Steiner, Dakshanamurthy, Vandenbussche, Hurley. Extracellular domain alterations impact surface expression of stimulatory natural killer cell receptor KIR2DS5. Immunogenetics. 2008 Aug 6; [Epub ahead of print]

Suprynowicz FA, Disbrow GL, Krawczyk E, Simic V, Lantzky K, Schlegel R.┬ HPV-16 E5 oncoprotein upregulates lipid raft components caveolin-1 and ganglioside GM1 at the plasma membrane of cervical cells.┬ Oncogene. 2008 Feb 14;27(8):1071-8.

Thibodeaux CA, Liu X, Disbrow GL, Zhang Y, Rone JD, Haddad BR, Schlegel R. Immortalization and transformation of human mammary epithelial cells by a tumor-derived Myc mutant. Breast Cancer Res Treat. 2008 Jul 20. [Epub ahead of print]

Vandenbussche CJ, Mulrooney TJ, Frazier WR, Dakshanamurthy S, Hurley CK. Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule. Genes Immun. 2008 Nov 13. [Epub ahead of print].

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