Molecular Targets & Therapeutic Resistance Program
Overview | Leaders | Research | Publications
Selected Publications
2008
Adhikari S., Manthena PV, Uren A, Roy R. Expression, purification and characterization of codon optimized human N-methylpurine-DNA glycosylase from Escherichia coli. Protein Express Purif 2008;58:257-262.
Adhikari S, Kennel SJ, Roy G, Mitra PS, Mitra S, Roy R. Discrimination of substrate recognition of N-Methylpurine-DNA glycosylase revealed by a potent neutralizing monoclonal antibody. DNA Repair 2008;7:31-39.
Adhikari S, Choudhury, S, Mitra PS, Dubash JJ, Sajankila SP, Roy R. Targeting base excision repair for chemosensitization. Anticancer Agents Med Chem 2008;8:351-357.
Adhikari S, Uren A, Roy R. Dipole-dipole interaction stabilizes the transition state of AP-endonuclease - abasic site interaction. J Biol Chem 2008;283:1334-1339.
Amundson SA., Do KT, Vinikoor LC, Lee RA, Koch-Paiz CA, Ahn J, Reimers M, Chen Y, Scudiero DA, Weinstein JN, Trent JM, Bittner ML, Meltzer PS, Fornace AJ. Integrating global gene expression and radiation survival parameters across the 60 cell lines of the NCI Anti-Cancer Drug Screen. Cancer Res 2008;68:415-424.
Bachis A, Mallei A, Cruz MI, Wellstein A, Mocchetti I. Chronic antidepressant treatments increase basic fibroblast growth factor and fibroblast growth factor-binding protein in neurons. Neuropharmacology 2008;55:1114-1120.
Bakin R, Jung M. HDAC2 cytoplasmic sequestration potentiates keratinocyte terminal differentiation. Open Cell Dev Biol J 2008;1:1-9.
Becerra SP, Perez-Mediavilla LA, Weldon JE, Locatelli-Hoops S, deS Senanayake P, Notari L, Notario V, Hollyfield JG. Pigment epithelium-derived factor (PEDF) binds to hyaluronan. Mapping of a hyaluronan binding site. J Biol Chem 2008;283:33310-33320.
Chen J, Ruczinski I, Jorgensen TJ, Yenokyan G, Yao Y, Alani R, Liégeois NJ, Hoffman SC, Hoffman-Bolton J, Strickland PT, Helzlsouer KJ, Alberg AJ. Nonmelanoma skin cancer and risk for subsequent malignancy. J Natl Cancer Inst 2008;100:1215-12122.
Cho MC, Choi HS, Kim EJ, Lee SJ, Kim BY, Jung M, Park SN, and Yoon DY. Epiregulin expression by Ets-1 and ERK signal pathway in Ki-/ras/-transformed cells. Biochemical and Biophysical Research Communications 2008 377: 832-837.
Choudhury S, Adhikari S, Cheema A, Roy R. Evidence of complete cellular repair of 1, N6-ethenoadenine, a mutagenic and potential damage for human cancer, revealed by a novel method. Mol Cell Biochem 2008;313:19-28.
Dilmanian FA, Romanelli P, Zhong Z, Wang R, Wagshul ME, Kalef-Ezra J, Maryanski MJ, Rosen EM, Anschel DJ. Microbeam radiation therapy: Tissue dose penetration and BANG-gel dosimetry of thick-beams' array interlacing. Eur J Radiol [Epub ahead of print] July 5, 2008.
Eisen A, Lubinski J, Gronwald J, Moller P, Lynch HT, Klijn J, Kim-Sing C, Neuhausen SL, Gilbert L, Ghadirian P, Manoukian S, Rennert G, Friedman E, Isaacs C, Rosen E, Rosen B, Daly M, Sun P, Narod SA, and the Hereditary Breast Cancer Clinical Study Group. J Natl Cancer Inst 2008;100:1361-1367.
Fan S, Meng Q, Laterra JJ, Rosen EM. Role of Src signal transduction pathways in scatter factor mediated cellular protection. Biol Chem. 2008 Dec 1. [Epub ahead of print].
Fereshteh MP, Tilli MT, Kim SE, Xu J, O'Malley BW, Wellstein A, Furth P, Riegel AT.The nuclear receptor coactivator amplified in breast cancer-1 is required for Neu (ErbB2/HER2) activation, signaling, and mammary tumorigenesis in mice. Cancer Res 2008;68:3697-3706.
Hu ZZ, Huang H, Cheema A, Jung M, Dritschilo A, Wu CH. Integrated Bioinformatics for Radiation-Induced Pathway Analysis from Proteomics and Microarray Data. Journal of Proteomics and Bioinformatics 2008;1:47-60
Jones LP, Tilli MT, Assefnia S, Torre K, Halama ED, Parrish A, Rosen EM, Furth PA. Activation of estrogen signaling pathways collaborates with loss of Brca1 to promote development of ERα-negative and ERα-positive mammary preneoplasia and cancer. Oncogene 2008;27:794-802.
Kasid U, Notario V, Haimovitz-Friedman A, Bar-Eli, M (Eds.), Reviews in Cancer Biology & Therapeutics. Research Signpost, Transworld Research Network/Old City Publishing, Trivandrum, India, 2008.
Kim JS, Bonifant C, Bunz F, Lane WS, Waldman T. Epitope tagging of endogenous genes in diverse human cell lines. Nucleic Acids Res 36: e127 [Epub Sep 10], 2008.
Kim TY, Kim IS, Jong HS, Lee JW, Kim TY, Jung M and Bang YJ. Transcriptional induction of DLC-1 gene through Sp1 sites by histone deacetylase inhibitors in gastric cancer cells. Experimental and Molecular Medicine 2008; 40: 639-646.
Konsoula R, Jung M. In vitro plasma stability, permeability and solubility of mercaptoacetamide histone deacetylase inhibitors. Int. J Pharm 2008;361:19-25.
Konsoula R and Jung M. Involvement of P-glycoprotein and multidrug resistance associated protein 1 in the transepithelial transport of a mercaptoacetamide-based histone-deacetylase inhibitor in Caco-2 cells. Biol Pharm Bull 2008; 32: 74-78.
Kwon O, Kim KA, He L, Kim SO, Bae EY, Cha EY, Kim CH, Sok DE, Jung M, Ahn JS, Kim BY. Ionizing radiation can induce GSK-3β phosphorylation and NF-kB transcriptional transactivation in ATM-deficient fibroblasts. Cell Signal 2008;20:602-612.
Lu X, Yang C, Hill R, Yin C, Hollander MC, Fornace AJ, Van Dyke T. Inactivation of gadd45a sensitizes epithelial cancer cells to ionizing radiation in vivo resulting in prolonged survival. Cancer Res 2008;68:3579-3583.
Marshall-Batty KR, Nakai H. Trans-targeting of protease substrates by conformationally activating a regulatable ClpX-recognition motif. Mol Microbiol 2008;67:920-933.
Marshall-Batty KR, Nakai H. Activation of a dormant ClpX recognition motif of bacteriophage Mu repressor by inducing high local flexibility. J Biol Chem 2008;283:9060-9070.
Massaro D, Massaro GD. Apoetm1Unc mice have impaired alveologenesis, low lung function, and rapid loss of lung function. Am J Physiol Lung Cell Mol Physiol 2008;294:L991-997.
Notario V, Tirado OM, Villar J. Molecular Basis of Radiation Therapy - Role of Chemotherapy in Combination with Radiation - New Targeted Therapies and Radiation. In: Molecular Biology in Cancer: Toward New Therapies (García-Foncillas J, Ed.), Prous Science SA, Barcelona, Spain (In press), 2008.
Notario V, Mateo-Lozano S, Villar J, Tirado OM. Targeting EWS/FLI1-driven signaling pathways for therapy of tumors of the Ewing's sarcoma family. In: The Handbook of Cell Signaling (Bradshaw R and Dennis E, Eds). Elsevier, San Diego, (In press), 2008.
Oh AS, Lahusen JT, Chien CD, Fereshteh MP, Zhang X, Dakshanamurthy S, Xu J, Kagan B, Wellstein A, Riegel AT. Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells. Mol Cell Biol 2008;28:6580-6593.
Patterson A, Li HH, Eichler G, Krausz K, Weinstein J, Fornace AJ, Gonzalez F, Idle J. UPLC-ESI-TOFMS-Based Metabolomics and GEDI Self-Organizing Metabolomic Maps as Tools for Understanding the Cellular Response to Ionizing Radiation. Anal Chem 2008;80:665-674.
Ramlo M, Moscovitch M, Rotunda JE. Further studies in the reduction of residual in Harshaw TLD-100H (LiF:Mg,Cu,P), Radiat Prot Dosimetry [advance access published on April 5, 2007], in press, 2008.
Ray R, Keyser B, Benton B, Daher A , Simbulan-Rosenthal CM, Rosenthal DS. Sulfur Mustard Induces Apoptosis in Cultured Normal Human Airway Epithelial Cells: Evidence of a Dominant Caspase-8-mediated pathway and Differential Cellular Responses. Drug Chem Toxicol 2008;31:137-148.
Reznik TE, Sang Y, Ma Y, Abounader R, Rosen EM, Xia S, Laterra J. Transcription-dependent epidermal growth factor receptor activation by hepatocyte growth factor. Mol Cancer Res 2008;6:139-150.
Rosen EM, Ma Y, Fan S. BRCA1 cross-talk with hormone receptors. In: "Hormone Receptors in Breast Cancer", S.A.W. Fuqua (ed.), Cancer Treatment and Research 312, Springer Science Business Media (In press), 2008.
Schäfer S, Saunders L, Eliseeva E, Velena A, Jung MO, Schwienhorst A, Strasser A, Dickmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg Med Chem 2008;16:2011-2033.
Skopec M, Loew M, Price J, Moscovitch M. Classification of mixed-radiation fields using the vector representation of thermoluminescent glow curves. Radiat Measurements, in press, 2008.
Soldatenkov VA, Vetcher AA, Duka T, Ladame S. First evidence of a functional interaction between DNA quadruplexes and poly(ADP-ribose) polymerase-1. ACS Chem Biol 2008;3:214-219.
Solomon DA, Kim JS, Cronin JC, Sibenaller Z, Ryken T, Rosenberg SA, Ressom H, Jean W, Bigner D, Yan H, Samuels Y, Waldman T. Mutational Inactivation of PTPRD in Glioblastoma Multiforme and Malignant Melanoma. Cancer Res 2008;68:10300-10306.
Solomon DA, Kim JS, Jenkins S, Ressom H, Huang M, Coppa N, Mabanta L, Bigner D, Yan H, Jean W, Waldman T. Identification of p18 INK4c as a tumor suppressor gene in glioblastoma multiforme. Cancer Res 2008;68:2564-2569.
Tyburski JB, Patterson AJ, Krausz KW, Slavik J, Fornace AJ, Gonzalez FJ, Idle JR. Radiation metabolomics: identification of minimally invasive urine biomarkers for gamma radiation exposure in mice. Radiation Res 2008;170:1-14.
Wang T, Simbulan-Rosenthal CM, Smulson ME, Chock PB, Yang DC. Polyubiquitylation of PARP-1 through ubiquitin K48 is modulated by activated DNA, NAD(+), and dipeptides. J Cell Biochem 2008104:318-328.
Wang Y, Saad M, Pakunlu RI, Khandare JJ, Garbuzenko OB, Vetcher AA, Soldatenkov VA, Pozharov VP, Minko T. Non-viral nanoscale-based delivery of antisense oligonucleotides targeted to hypoxia-inducible factor 1 alpha enhances the efficacy of chemotherapy in multidrug resistant tumor. Clin Cancer Res 2008;14:3607-3616.
Zhang W, Chen Y, Swift MR, Tassi E, Stylianou DC, Gibby KA, Riegel AT, Wellstein A. Effect of FGF binding protein-3 on vascular permeability. J Biol Chem 2008;283:28329-28337.
