Experimental Therapeutics Program
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Selected Publications
2007
Abe K, Tilan JU, Zukowska Z. NPY and NPY receptors in vascular remodeling. Curr Top Med Chem 2007;7(17):1704-1709.
Alexandrescu DT, Wiernik PH. The influence of parental age and gender on anticipation in familial B-cell malignancies. Med Oncol 2007;24(1):55-62.
Amoah LE, Lekostaj JK, Roepe PD. Heterologous expression and ATPase activity of mutant versus wild type PfMDR1 protein. Biochemistry 2007;46(20):6060-6073.
Ams MR, Wilcox CS. Benzil-tethered precipitons for controlling solubility: a round-trip energy-transfer mechanism in the isomerization of extended stilbene analogues. J Am Chem Soc 2007;129(13):3966-3972.
Asatiani E, Kessler CM. Multiple congenital coagulopathies co-expressed with Von Willebrand's disease: the experience of Hemophilia Region III Treatment Centers over 25 years and review of the literature. Haemophilia 2007;13(6):685-696.
Avvisato CL, Yang X, Shah S, Hoxter B, Li W, Gaynor R, Pestell R, Tozeren A, Byers SW. Mechanical force modulates global gene expression and beta-catenin signaling in colon cancer cells. J Cell Sci 2007;120(Pt 15):2672-2682.
Badros A, Karakunnel J, Dawson N. Multiple myeloma and renal cell carcinoma possible association. Leuk Lymphoma 2007;48(8):1662-1664.
Bennett TN, Patel J, Ferdig MT, Roepe PD. Plasmodium falciparum Na+/H+ exchanger activity and quinine resistance. Mol Biochem Parasitol 2007;153(1):48-58.
Bhayana B, Wilcox CS. A minimal protein folding model to measure hydrophobic and CH-pi effects on interactions between nonpolar surfaces in water. Angew Chem Int Ed Engl 2007;46(36):6833-
Boccia R, Lillie T, Tomita D, Balducci L. The effectiveness of darbepoetin alfa administered every 3 weeks on hematologic outcomes and quality of life in older patients with chemotherapy-induced anemia. Oncologist 2007;12(5):584-593.
Borresen ML, Wang D, Strandgaard S. Pulse wave reflection is amplified in normotensive patients with autosomal-dominant polycystic kidney disease and normal renal function. Am J Nephrol 2007;27(3):240-246.
Byers S, Shah S. Vitamin D and the regulation of Wnt/beta-catenin signaling and innate immunity in colorectal cancer. Nutr Rev 2007;65(8 Pt 2):S118-S120.
Byrnes KR, Faden AI. Role of cell cycle proteins in CNS injury. Neurochem Res 2007;32(10):1799-1807.
Byrnes KR, Stoica BA, Fricke S, Di Giovanni S, Faden AI. Cell cycle activation contributes to post-mitotic cell death and secondary damage after spinal cord injury. Brain 2007;130(Pt 11):2977-2992.
Chaterji R, Tractenberg RE, Amri H, Lumpkin M, Amorosi SB, Haramati A. A large-sample survey of first- and second-year medical student attitudes toward complementary and alternative medicine in the curriculum and in practice. Altern Ther Health Med 2007;13(1):30-35.
Chen X, Patel K, Connors SG, Mendonca M, Welch WJ, Wilcox CS. Acute antihypertensive action of Tempol in the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol 2007;293(6):H3246-H3253.
Cheson BD. The International Harmonization Project for response criteria in lymphoma clinical trials. Hematol Oncol Clin North Am 2007;21(5):841-854.
Cheson BD. Overcoming mechanisms of RECISTance in lymphoma. Leuk Lymphoma 2007;48(3):447-448.
Cheson BD, Gregory SA, Marcus R. Emerging treatments for indolent lymphoma. Clin Adv Hematol Oncol 2007;5(5 Suppl 8):1-12.
Cheson BD. Oblimersen for the treatment of patients with chronic lymphocytic leukemia. Ther Clin Risk Manag 2007;3(5):855-870.
Chen Y, Pearlman A, Luo Z, Wilcox CS. Hydrogen peroxide mediates a transient vasorelaxation with tempol during oxidative stress. Am J Physiol Heart Circ Physiol 2007;293(4):H2085-H2092.
Cheson BD, Pfistner B, Juweid ME, Gascoyne RD, Specht L, Horning SJ, Coiffier B, Fisher RI, Hagenbeek A, Zucca E, Rosen ST, Stroobants S, Lister TA, Hoppe RT, Dreyling M, Tobinai K, Vose JM, Connors JM, Federico M, Diehl V. Revised response criteria for malignant lymphoma. J Clin Oncol 2007;25(5):579-586.
Cohen PJ. Addiction, molecules and morality: disease does not obviate responsibility. Am J Bioeth 2007;7(1):21-23.
Czuczman MS, Porcu P, Johnson J, Niedzwiecki D, Kelly M, Hsi ED, Cook JR, Canellos G, Cheson BD. Results of a phase II study of 506U78 in cutaneous T-cell lymphoma and peripheral T-cell lymphoma: CALGB 59901. Leuk Lymphoma 2007;48(1):97-103.
Chruszcz M, Kong Y, Dauter Z, Brown ML, and Minor W. 2-Amino-4-(4-chloro-3-methylphenyl)-5-propyl-1,3-thiazolium iodide. Acta Crystallographica 2007;E63:1598-1600.
Dakshanamurthy S, Kim M, Brown ML, Byers SW. In-silico fragment-based identification of novel angiogenesis inhibitors. Bioorg Med Chem Lett 2007;17(16):4551-4556.
Dasanu CA, Wiernik PH, Vaillant J, Alexandrescu DT. A complex pattern of melanonychia and onycholysis after treatment with pemetrexed for lung cancer. Skinmed 2007;6(2):95-96.
Dasanu CA, Alexandrescu DT, Dutcher J. Yellow skin discoloration associated with sorafenib use for treatment of metastatic renal cell carcinoma. South Med J 2007;100(3):328-330.
Dawson NA. Epothilones in prostate cancer: review of clinical experience. Ann Oncol 2007;18 Suppl 5:v22-v27.
Deeken JF, Loscher W. The blood-brain barrier and cancer: transporters, treatment, and Trojan horses. Clin Cancer Res 2007;13(6):1663-1674.
Deeken JF, Figg WD, Bates SE, Sparreboom A. Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics. Anticancer Drugs 2007;18(2):111-126.
Delvi MB, Samarkandi A, Zahrani T, Faden A. Recovery profile for magnetic resonance imaging in pediatric daycase--sevoflurane vs. isoflurane. Middle East J Anesthesiol 2007;19(1):205-211.
Faden AI, Stoica B. Neuroprotection: challenges and opportunities. Arch Neurol 2007;64(6):794-800.
Fuchs CS, Marshall J, Mitchell E, Wierzbicki R, Ganju V, Jeffery M, Schulz J, Richards D, Soufi-Mahjoubi R, Wang B, Barrueco J. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: results from the BICC-C Study. J Clin Oncol 2007;25(30):4779-4786.
Fumino K, Diakova G, Andersen D, Brown ML, and Bryant RG. Solvation and intermolecular exploration of drug molecular fragments. Journal of Solution Chemistry 2007;36(6):715-722.
Gagnon GJ, Henderson FC, Gehan EA, Sanford D, Collins BT, Moulds JC, Dritschilo A. Cyberknife radiosurgery for breast cancer spine metastases: a matched-pair analysis. Cancer 2007;110(8):1796-1802.
Gorczynski MJ, Grembecka J, Zhou Y, Kong Y, Roudaia L, Douvas MG, Newman M, Bielnicka I, Baber G, Corpora T, Shi J, Sridharan M, Lilien R, Donald BR, Speck NA, Brown ML, Bushweller JH. Allosteric inhibition of the protein-protein interaction between the leukemia-associated proteins Runx1 and CBFbeta. Chem Biol 2007;14(10):1186-1197.
Holder S, Lilly M, Brown ML. Comparative molecular field analysis of flavonoid inhibitors of the PIM-1 kinase. Bioorg Med Chem 2007;15(19):6463-6473.
Holst JP, Soldin SJ, Tractenberg RE, Guo T, Kundra P, Verbalis JG, Jonklaas J. Use of steroid profiles in determining the cause of adrenal insufficiency. Steroids 2007;72(1):71-84.
Hu ZZ, Valencia JC, Huang H, Chi A, Shabanowitz J, Hearing VJ, Appella E, Wu C. Comparative Bioinformatics Analyses and Profiling of Lysosome-Related Organelle Proteomes. Int J Mass Spectrom 2007;259(1-3):147-160.
Huang H, Hu ZZ, Arighi CN, Wu CH. Integration of bioinformatics resources for functional analysis of gene expression and proteomic data. Front Biosci 2007;12:5071-5088.
Hwang JJ. Role of chemotherapy in the treatment of gastroesophageal cancers. Oncology (Williston Park) 2007;21(5):579-586.
Jones PJ, Wang Y, Smith MD, Hargus NJ, Eidam HS, White HS, Kapur J, Brown ML, Patel MK. Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity. J Pharmacol Exp Ther 2007;320(2):828-836.
Jonklaas J. Role of radioactive iodine for adjuvant therapy and treatment of metastases. J Natl Compr Canc Netw 2007;5(6):631-640.
Ju X, Katiyar S, Wang C, Liu M, Jiao X, Li S, Zhou J, Turner J, Lisanti MP, Russell RG, Mueller SC, Ojeifo J, Chen WS, Hay N, Pestell RG. Akt1 governs breast cancer progression in vivo. Proc Natl Acad Sci U S A 2007;104(18):7438-7443.
Juweid ME, Stroobants S, Hoekstra OS, Mottaghy FM, Dietlein M, Guermazi A, Wiseman GA, Kostakoglu L, Scheidhauer K, Buck A, Naumann R, Spaepen K, Hicks RJ, Weber WA, Reske SN, Schwaiger M, Schwartz LH, Zijlstra JM, Siegel BA, Cheson BD. Use of positron emission tomography for response assessment of lymphoma: consensus of the Imaging Subcommittee of International Harmonization Project in Lymphoma. J Clin Oncol 2007;25(5):571-578.
Kahric-Janicic N, Soldin SJ, Soldin OP, West T, Gu J, Jonklaas J. Tandem mass spectrometry improves the accuracy of free thyroxine measurements during pregnancy. Thyroid 2007;17(4):303-311.
Kaufman HL, Kim-Schulze S, Manson K, DeRaffele G, Mitcham J, Seo KS, Kim DW, Marshall J. Poxvirus-based vaccine therapy for patients with advanced pancreatic cancer. J Transl Med 2007;5:60.
Kim JS, Kondratyev A, Tomita Y, Gale K. Neurodevelopmental impact of antiepileptic drugs and seizures in the immature brain. Epilepsia 2007;48 Suppl 5:19-26.
Kitisin K, Ganesan N, Tang Y, Jogunoori W, Volpe EA, Kim SS, Katuri V, Kallakury B, Pishvaian M, Albanese C, Mendelson J, Zasloff M, Rashid A, Fishbein T, Evans SR, Sidawy A, Reddy EP, Mishra B, Johnson LB, Shetty K, Mishra L. Disruption of transforming growth factor-beta signaling through beta-spectrin ELF leads to hepatocellular cancer through cyclin D1 activation. Oncogene 2007;26(50):7103-7110.
Kitisin K, Shetty K, Mishra L, Johnson LB. Hepatocellular stem cells. Cancer Biomark 2007;3(4-5):251-262.
Kitisin K, Saha T, Blake T, Golestaneh N, Deng M, Kim C, Tang Y, Shetty K, Mishra B, Mishra L. Tgf-Beta signaling in development. Sci STKE 2007;2007(399):cm1.
Kuo AH, Stoica GE, Riegel AT, Wellstein A. Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase. Oncogene 2007;26(6):859-869.
Kuo LE, Kitlinska JB, Tilan JU, Li L, Baker SB, Johnson MD, Lee EW, Burnett MS, Fricke ST, Kvetnansky R, Herzog H, Zukowska Z. Neuropeptide Y acts directly in the periphery on fat tissue and mediates stress-induced obesity and metabolic syndrome. Nat Med 2007;13(7):803-811.
Lahusen T, Fereshteh M, Oh A, Wellstein A, Riegel AT. Epidermal growth factor receptor tyrosine phosphorylation and signaling controlled by a nuclear receptor coactivator, amplified in breast cancer. Cancer Res 2007;67(15):7256-7265.
Lenkowski PW, Batts TW, Smith MD, Ko SH, Jones PJ, Taylor CH, McCusker AK, Davis GC, Hartmann HA, White HS, Brown ML, Patel MK. A pharmacophore derived phenytoin analogue with increased affinity for slow inactivated sodium channels exhibits a desired anticonvulsant profile. Neuropharmacology 2007;52(3):1044-1054.
Levy EB, Zhang H, Lindisch D, Wood BJ, Cleary K. Electromagnetic tracking-guided percutaneous intrahepatic portosystemic shunt creation in a swine model. J Vasc Interv Radiol 2007;18(2):303-307.
Levy EB, Tang J, Lindisch D, Glossop N, Banovac F, Cleary K. Implementation of an electromagnetic tracking system for accurate intrahepatic puncture needle guidance: accuracy results in an in vitro model. Acad Radiol 2007;14(3):344-354.
Li F, Luo Z, Huang W, Lu Q, Wilcox CS, Jose PA, Chen S. Response gene to complement 32, a novel regulator for transforming growth factor-beta-induced smooth muscle differentiation of neural crest cells. J Biol Chem 2007;282(14):10133-10137.
Long TM, Woolverton M, Perry DF, Thomas MJ. Training needs of pediatric occupational therapists in assistive technology. Am J Occup Ther 2007;61(3):345-354.
Lynch JH, Loeb S. The role of high-intensity focused ultrasound in prostate cancer. Curr Oncol Rep 2007;9(3):222-225.
Marshall JL. Bevacizumab in the treatment of colorectal cancer. Clin Adv Hematol Oncol 2007;5(1 Suppl 1):8-9.
Marshall JL, Gehan EA. The development of novel agents for the treatment of colorectal cancer: a critical review of current practice and some suggestions for the future. Clin Adv Hematol Oncol 2007;5(3):167-172.
Mazumder R, Hu ZZ, Vinayaka CR, Sagripanti JL, Frost SD, Kosakovsky Pond SL, Wu CH. Computational analysis and identification of amino acid sites in dengue E proteins relevant to development of diagnostics and vaccines. Virus Genes 2007;35(2):175-186.
Mishra L. Stem cell and cancer. Cancer Biomarkers 2007;3-5:109-274. (Guest Editor)
Mooberry SL, Weiderhold KN, Dakshanamurthy S, Hamel E, Banner EJ, Kharlamova A, Hempel J, Gupton JT, Brown ML. Identification and characterization of a new tubulin-binding tetrasubstituted brominated pyrrole. Mol Pharmacol 2007;72(1):132-140.
Moore D, Cohen P, Malik S. HIV-related large B-cell lymphoma confined to the bone marrow with a fulminant clinical course: a case report and literature review. Clin Adv Hematol Oncol 2007;5(8):622-624.
Natale DA, Arighi CN, Barker WC, Blake J, Chang TC, Hu Z, Liu H, Smith B, Wu CH. Framework for a protein ontology. BMC Bioinformatics 2007;8 Suppl 9:S1.
Natarajan TG, FitzGerald KT. Markers in normal and cancer stem cells. Cancer Biomark 2007;3(4-5):211-231.
Nava VE, Cohen P, Bishop M, Fowler D, Jaffe ES, Ozdemirli M. Enteropathy-type T-cell lymphoma after intestinal diffuse large B-cell lymphoma. Am J Surg Pathol 2007;31(3):476-480.
Nie L, Wu G, Culley DE, Scholten JC, Zhang W. Integrative analysis of transcriptomic and proteomic data: challenges, solutions and applications. Crit Rev Biotechnol 2007;27(2):63-75.
Nosheny RL, Ahmed F, Yakovlev A, Meyer EM, Ren K, Tessarollo L, Mocchetti I. Brain-derived neurotrophic factor prevents the nigrostriatal degeneration induced by human immunodeficiency virus-1 glycoprotein 120 in vivo. Eur J Neurosci 2007;25(8):2275-2284.
Nouri P, Gill P, Li M, Wilcox CS, Welch WJ. p22phox in the macula densa regulates single nephron GFR during angiotensin II infusion in rats. Am J Physiol Heart Circ Physiol 2007;292(4):H1685-H1689.
Palm F, Onozato ML, Luo Z, Wilcox CS. Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems. Am J Physiol Heart Circ Physiol 2007;293(6):H3227-H3245.
Pirollo KF, Rait A, Zhou Q, Hwang SH, Dagata JA, Zon G, Hogrefe RI, Palchik G, Chang EH. Materializing the potential of small interfering RNA via a tumor-targeting nanodelivery system. Cancer Res 2007;67(7):2938-2943.
Pishviaian MJ, Byers SW. Biomarkers of WNT signaling. Cancer Biomark 2007; 3(4-5):263-274.
Robey RW, Polgar O, Deeken J, To KW, Bates SE. ABCG2: determining its relevance in clinical drug resistance. Cancer Metastasis Rev 2007;26(1):39-57.
Sadowsky JD, Murray JK, Tomita Y, Gellman SH. Exploration of backbone space in foldamers containing alpha- and beta-amino acid residues: developing protease-resistant oligomers that bind tightly to the BH3-recognition cleft of Bcl-xL. Chembiochem 2007;8(8):903-916.
Sadowsky JD, Fairlie WD, Hadley EB, Lee HS, Umezawa N, Nikolovska-Coleska Z, Wang S, Huang DC, Tomita Y, Gellman SH. (alpha/beta+alpha)-peptide antagonists of BH3 domain/Bcl-x(L) recognition: toward general strategies for foldamer-based inhibition of protein-protein interactions. J Am Chem Soc 2007;129(1):139-154.
Saltz LB, Rosen LS, Marshall JL, Belt RJ, Hurwitz HI, Eckhardt SG, Bergsland EK, Haller DG, Lockhart AC, Rocha Lima CM, Huang X, DePrimo SE, Chow-Maneval E, Chao RC, Lenz HJ. Phase II trial of sunitinib in patients with metastatic colorectal cancer after failure of standard therapy. J Clin Oncol 2007;25(30):4793-4799.
Samara RN, Laguinge LM, Jessup JM. Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling. Cancer Res 2007;67(10):4774-4782.
Saunders PA, Tractenberg RE, Chaterji R, Amri H, Harazduk N, Gordon JS, Lumpkin M, Haramati A. Promoting self-awareness and reflection through an experiential Mind-Body Skills course for first year medical students. Med Teach 2007;1-7.
Suzek BE, Huang H, McGarvey P, Mazumder R, Wu CH. UniRef: comprehensive and non-redundant UniProt reference clusters. Bioinformatics 2007;23(10):1282-1288.
Tassi E, Walter S, Aigner A, Cabal-Manzano RH, Ray R, Reier PJ, Wellstein A. Effects on neurite outgrowth and cell survival of a secreted fibroblast growth factor binding protein upregulated during spinal cord injury. Am J Physiol Regul Integr Comp Physiol 2007;293(2):R775-R783.
Tisnado DM, Adams JL, Liu H, Damberg CL, Hu A, Chen WP, Kahn KL. Does concordance between data sources vary by medical organization type? Am J Manag Care 2007;13(6 Part 1):289-296.
Torii M, Hu ZZ, Song M, Wu CH, Liu H. A comparison study on algorithms of detecting long forms for short forms in biomedical text. BMC Bioinformatics 2007;8 Suppl 9:S5.
Wang D, Gill PS, Chabrashvili T, Onozato ML, Raggio J, Mendonca M, Dennehy K, Li M, Modlinger P, Leiper J, Vallance P, Adler O, Leone A, Tojo A, Welch WJ, Wilcox CS. Isoform-specific regulation by N(G),N(G)-dimethylarginine dimethylaminohydrolase of rat serum asymmetric dimethylarginine and vascular endothelium-derived relaxing factor/NO. Circ Res 2007;101(6):627-635.
Wang Z, Armando I, Asico LD, Escano C, Wang X, Lu Q, Felder RA, Schnackenberg CG, Sibley DR, Eisner GM, Jose PA. The elevated blood pressure of human GRK4gamma A142V transgenic mice is not associated with increased ROS production. Am J Physiol Heart Circ Physiol 2007;292(5):H2083-H2092.
Welch WJ, Patel K, Modlinger P, Mendonca M, Kawada N, Dennehy K, Aslam S, Wilcox CS. Roles of vasoconstrictor prostaglandins, COX-1 and -2, and AT1, AT2, and TP receptors in a rat model of early 2K,1C hypertension. Am J Physiol Heart Circ Physiol 2007;293(5):H2644-H2649.
Wieghaus KA, Gianchandani EP, Brown ML, Papin JA, and Botchwey EA. Mechanistic exploration of phthalimide neovascular factor 1 using network analysis tools. Tissue Eng 2007;13(10):2561-75.
Wong KH, Dieterich S, Tang J, Cleary K. Quantitative Measurement of CyberKnife Robotic Arm Steering. Technol Cancer Res Treat 2007;6(6):589-594.
Yousefi S, Collins BT, Reichner CA, Anderson ED, Jamis-Dow C, Gagnon G, Malik S, Marshall B, Chang T, Banovac F. Complications of thoracic computed tomography-guided fiducial placement for the purpose of stereotactic body radiation therapy. Clin Lung Cancer 2007;8(4):252-256.
Zhang S, Jonklaas J, Danielsen M. The glucocorticoid agonist activities of mifepristone (RU486) and progesterone are dependent on glucocorticoid receptor levels but not on EC50 values. Steroids 2007;72(6-7):600-608.
