Drug Discovery & Developmental Therapeutics Program
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Selected Publications
2005
Abaan OD, Levenson A, Khan O, Furth PA, Uren A, Toretsky JA. PTPL1 is a direct transcriptional target of EWS-FLI1 and modulates Ewing's Sarcoma tumorigenesis. Oncogene 2005;24(16):2715-2722.
Akula N, Pattabiraman N. A systematic search method for the identification of tightly packed transmembrane parallel alpha-helices. J Biomol Struct Dyn 2005;22(6):625-634.
Banovac F, Tang J, Xu S, Lindisch D, Chung HY, Levy EB, Chang T, McCullough MF, Yaniv Z, Wood BJ, Cleary K. Precision targeting of liver lesions using a novel electromagnetic navigation device in physiologic phantom and swine. Med Phys 2005;32(8):2698-2705.
Bennett TN, Kosar AD, Roepe PD. Plasmodium falciparum strain GC-03 exhibits hyper-gametocytogenesis in partially hemoglobin depleted red blood cells. Mol Biochem Parasitol 2005;139(2):261-265.
Berg M, Difatta J, Hoiczyk E, Schlegel R, Ketner G. Viable adenovirus vaccine prototypes: high-level production of a papillomavirus capsid antigen from the major late transcriptional unit. Proc Natl Acad Sci U S A 2005;102(12):4590-4595.
Bowen-Wright HE, Jonklaas J. Ectopic intratracheal thyroid: an illustrative case report and literature review. Thyroid 2005;102:4590-5.
Bracho FA. Hereditary angioedema. Curr Opin Hematol 2005;12(6):493-498.
Cernak I, Stoica B, Byrnes KR, Di Giovanni S, Faden AI. Role of the cell cycle in the pathobiology of central nervous system trauma. Cell Cycle 2005;4(9):1286-1293.
Cheson BD. The role of radioimmunotherapy with yttrium-90 ibritumomab tiuxetan in the treatment of non-Hodgkin lymphoma. BioDrugs 2005;19(5):309-322.
Cheson BD. CT/PET scan. Clin Adv Hematol Oncol 2005;3(9):483.
Chiba-Falek O, Kowalak JA, Smulson ME, Nussbaum RL. Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene. Am J Hum Genet 2005;76(3):478-492.
Cleary K. Medical robotics and the operating room of the future. Conf Proc IEEE Eng Med Biol Soc 2005;7:7250-7253.
Cleary K, Watson V, Lindisch D, Taylor RH, Fichtinger G, Xu S, White CS, Donlon J, Taylor M, Patriciu A, Mazilu D, Stoianovici D. Precision placement of instruments for minimally invasive procedures using a "needle driver" robot. Int J Med Robot 2005;1(2):40-47.
Cleary K, Kinsella A. OR 2020: the operating room of the future. J Laparoendosc Adv Surg Tech A 2005;15(5):495, 497-495, 573.
Cleary K, Zhang H, Glossop N, Levy E, Wood B, Banovac F. Electromagnetic tracking for image-guided abdominal procedures: overall system and technical issues. Conf Proc IEEE Eng Med Biol Soc 2005;7:6748-6753.
Cleary K, Watson V, Lindisch D, Taylor RH, Fichtinger G, Xu S, White CS, Donlon J, Taylor M, Patriciu A, Mazilu D, Stoianovici D. Precision placement of instruments for minimally invasive procedures using a "needle driver" robot. Int J Med Robot 2005;1(2):40-47.
De Biase A, Knoblach SM, Di Giovanni S, Fan C, Molon A, Hoffman EP, Faden AI. Gene expression profiling of experimental traumatic spinal cord injury as a function of distance from impact site and injury severity. Physiol Genomics 2005;22(3):368-381.
Di Giovanni S, Faden AI, Yakovlev A, Duke-Cohan JS, Finn T, Thouin M, Knoblach S, De Biase A, Bregman BS, Hoffman EP. Neuronal plasticity after spinal cord injury: identification of a gene cluster driving neurite outgrowth. FASEB J 2005;19(1):153-154.
Di Giovanni S, Movsesyan V, Ahmed F, Cernak I, Schinelli S, Stoica B, Faden AI. Cell cycle inhibition provides neuroprotection and reduces glial proliferation and scar formation after traumatic brain injury. Proc Natl Acad Sci U S A 2005;102(23):8333-8338.
Di Giovanni S, De Biase A, Yakovlev A, Finn T, Beers J, Hoffman EP, Faden AI. In vivo and in vitro characterization of novel neuronal plasticity factors identified following spinal cord injury. J Biol Chem 2005;280(3):2084-2091.
Disbrow GL, Hanover JA, Schlegel R. Endoplasmic reticulum-localized human papillomavirus type 16 E5 protein alters endosomal pH but not trans-Golgi pH. J Virol 2005;79(9):5839-5846.
Disbrow GL, Baege AC, Kierpiec KA, Yuan H, Centeno JA, Thibodeaux CA, Hartmann D, Schlegel R. Dihydroartemisinin is cytotoxic to papillomavirus-expressing epithelial cells in vitro and in vivo. Cancer Res 2005;65(23):10854-10861.
Enquobahrie A, Gobbi D, Turek M, Cheng P, Yaniv Z, Lindseth F, Cleary K. Designing tracking software for image-guided surgery applications: IGSTK experience. International Journal of Computer Assisted Radiology and Surgery, Springer, 04.07.2008, vol. 3, no. 5, pp. 395-403.
Espinoza LA, Valikhani M, Cossio MJ, Carr T, Jung M, Hyde J, Witten ML, Smulson ME. Altered expression of gamma-synuclein and detoxification-related genes in lungs of rats exposed to JP-8. Am J Respir Cell Mol Biol 2005;32(3):192-200.
Faden AI, Knoblach SM, Movsesyan VA, Lea PM, Cernak I. Novel neuroprotective tripeptides and dipeptides. Ann N Y Acad Sci 2005;1053:472-481.
Faden AI, Movsesyan VA, Knoblach SM, Ahmed F, Cernak I. Neuroprotective effects of novel small peptides in vitro and after brain injury. Neuropharmacology 2005;49(3):410-424.
Ganesan N, Bennett NF, Velauthapillai M, Pattabiraman N, Squier R, Kalyanasundaram B. Web-based interface facilitating sequence-to-structure analysis of BLAST alignment reports. Biotechniques 2005;39(2):186, 188.
Genther Williams SM, Disbrow GL, Schlegel R, Lee D, Threadgill DW, Lambert PF. Requirement of epidermal growth factor receptor for hyperplasia induced by E5, a high-risk human papillomavirus oncogene. Cancer Res 2005;65(15):6534-6542.
Gonzalez CE, Pengetze YM. Post-transfusion purpura. Curr Hematol Rep 2005;4(2):154-159.
Isaacs C, Slack R, Gehan E, Ballen K, Boccia R, Areman E, Kramer R, Hayes DF, Herscowitz H, Lippman M. A multicenter randomized clinical trial evaluating interleukin-2 activated hematopoietic stem cell transplantation and post-transplant IL-2 for high risk breast cancer patients. Breast Cancer Res Treat 2005;93(2):125-134.
Jonklaas J. Atypical presentation of a patient with both kallmann syndrome and a craniopharyngioma: case report and literature review. Endocr Pract 2005;11(1):30-36.
Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O'Shaughnessy J, Cheson BD, Sigman CC, Tatum JL, Mills GQ, Sullivan DC, Woodcock J. The progress and promise of molecular imaging probes in oncologic drug development. Clin Cancer Res 2005;11(22):7967-7985.
Kessler CM. New perspectives in hemophilia treatment. Hematology Am Soc Hematol Educ Program 2005;429-435.
Kessler CM, Gill JC, White GC, Shapiro A, Arkin S, Roth DA, Meng X, Lusher JM. B-domain deleted recombinant factor VIII preparations are bioequivalent to a monoclonal antibody purified plasma-derived factor VIII concentrate: a randomized, three-way crossover study. Haemophilia 2005;11(2):84-91.
Kitlinska J, Abe K, Kuo L, Pons J, Yu M, Li L, Tilan J, Everhart L, Lee EW, Zukowska Z, Toretsky JA. Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors. Cancer Res 2005;65(5):1719-1728.
Knoblach SM, Huang X, VanGelderen J, Calva-Cerqueira D, Faden AI. Selective caspase activation may contribute to neurological dysfunction after experimental spinal cord trauma. J Neurosci Res 2005;80(3):369-380.
Lea PM, Movsesyan VA, Faden AI. Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. Br J Pharmacol 2005;145(4):527-534.
Levy B, Deeken JF, Holt G, Marshall JL. Immunologic therapies for gastrointestinal cancers. Clin Colorectal Cancer 2005;5(1):37-49.
Lindsay JR, Jonklaas J, Oldfield EH, Nieman LK. Cushing's syndrome during pregnancy: personal experience and review of the literature. J Clin Endocrinol Metab 2005;90(5):3077-3083.
Liu A, Wu C, Yu KF, Gehan E. Supplementary analysis of probabilities at the termination of a group sequential phase II trial. Stat Med 2005;24(7):1009-1027.
Liu X, Yuan H, Fu B, Disbrow GL, Apolinario T, Tomaic V, Kelley ML, Baker CC, Huibregtse J, Schlegel R. The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein. J Biol Chem 2005;280(11):10807-10816.
Lu R, Burman KD, Jonklaas J. Transient Graves' hyperthyroidism during pregnancy in a patient with Hashimoto's hypothyroidism. Thyroid 2005; 15(7):725-729.
Ma YX, Tomita Y, Fan S, Wu K, Tong Y, Zhao Z, Song LN, Goldberg ID, Rosen EM. Structural determinants of the BRCA1 : estrogen receptor interaction. Oncogene 2005;24(11):1831-1846.
Magal SS, Jackman A, Ish-Shalom S, Botzer LE, Gonen P, Schlegel R, Sherman L. Downregulation of Bax mRNA expression and protein stability by the E6 protein of human papillomavirus 16. J Gen Virol 2005;86(Pt 3):611-621.
Mandal AK, Ray R, Zhang Z, Chowdhury B, Pattabiraman N, Mukherjee AB. Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. J Bio Chem 2005;280(38):32897-904.
Marshall JL. Novel vaccines for the treatment of gastrointestinal cancers. Oncology (Williston Park) 2005;19(12):1557-1565.
Marshall JL, Gulley JL, Arlen PM, Beetham PK, Tsang KY, Slack R, Hodge JW, Doren S, Grosenbach DW, , Fox E, Odogwu L, Park S, Panicali D, Schlom J. Phase I study of sequential vaccinations with fowlpox-CEA(6D)-TRICOM alone and sequentially with vaccinia-CEA(6D)-TRICOM, with and without granulocyte-macrophage colony-stimulating factor, in patients with carcinoembryonic antigen-expressing carcinomas. J Clin Oncol 2005;23(4):720-731.
Marshall JL, Kindler H, Deeken J, Bhargava P, Vogelzang NJ, Rizvi N, Luhtala T, Boylan S, Dordal M, Robertson P, Hawkins MJ, Ratain MJ. Phase I trial of orally administered CEP-701, a novel neurotrophin receptor-linked tyrosine kinase inhibitor. Invest New Drugs 2005;23(1):31-37.
Marshall JL, Hwang J. The impact of targeted therapy on the treatment of colorectal cancer. Oncology (Williston Park) 2005;19(13 Suppl 6):19-24.
Martinez ED, Pattabiraman N, Danielsen M. Analysis of the hormone-binding domain of steroid receptors using chimeras generated by homologous recombination. Exp Cell Res 2005;308(2):320-333.
McGrath CF, Pattabiraman N, Kellogg GE, Lemcke T, Kunick C, Sausville EA, Zaharevitz DW, Gussio R. Homology model of the CDK1/cyclin B complex. J Biomol Struct Dyn 2005;22(5):493-502.
Nanda NK, Bikoff EK. DM peptide-editing function leads to immunodominance in CD4 T cell responses in vivo. J Immunol 2005;175(10):6473-6480.
Parameswaran R, Shapiro AD, Gill JC, Kessler CM. Dose effect and efficacy of rFVIIa in the treatment of haemophilia patients with inhibitors: analysis from the Hemophilia and Thrombosis Research Society Registry. Haemophilia 2005;11(2):100-106.
Sadowsky JD, Schmitt MA, Lee HS, Umezawa N, Wang S, Tomita Y, Gellman SH. Chimeric (alpha/beta + alpha)-peptide ligands for the BH3-recognition cleft of Bcl-XL: critical role of the molecular scaffold in protein surface recognition. J Am Chem Soc 2005;127(34):11966-11968.
Shad AT, Gonzalez CE, Sandler SG. Treatment of immune thrombocytopenic purpura in children: current concepts. Paediatr Drugs 2005;7(5):325-336.
Shah S, Kapoor A, Ding J, Guion P, Petrisor D, Karanian J, Pritchard WF, Stoianovici D, Wood BJ, Cleary K. Robotically assisted needle driver: evaluation of safety release, force profiles, and needle spin in a swine abdominal model. International Journal of Computer Assisted Radiology and Surgery, Springer, 21.05.2008, vol. 3, no. 1, pp. 173-179.
Sivanesan D, Rajnarayanan RV, Doherty J, Pattabiraman N. In-silico screening using flexible ligand binding pockets: a molecular dynamics-based approach. J Comput Aided Mol Des 2005;19(4):213-228.
Sridhar J, Akula N, Sivanesan D, Narasimhan M, Rathinavelu A, Pattabiraman N. Identification of novel angiogenesis inhibitors. Bioorg Med Chem Lett 2005;15(18):4125-4129.
Stearns V, Slack R, Greep N, Henry-Tilman R, Osborne M, Bunnell C, Ullmer L, Gallagher A, Cullen J, Gehan E, Hayes DF, Isaacs C. Paroxetine is an effective treatment for hot flashes: results from a prospective randomized clinical trial. J Clin Oncol 2005;23(28):6919-6930.
Stewart KS, Rhim CH, Bahrain ML, Ashkezari ZD, Ozdemirli M, Fishbein TM, Johnson LB, Lu AD, Plotkin JS. Nonischemic cardiomyopathy after orthotopic liver transplantation: a report of three cases and a review of the literature. Liver Transpl 2005;11(5):573-578.
Stiefel MF, Tomita Y, Marmarou A. Secondary ischemia impairing the restoration of ion homeostasis following traumatic brain injury. J Neurosurg 2005;103(4):707-714.
Stoica BA, Movsesyan VA, Knoblach SM, Faden AI. Ceramide induces neuronal apoptosis through mitogen-activated protein kinases and causes release of multiple mitochondrial proteins. Mol Cell Neurosci 2005;29(3):355-371.
Suprynowicz FA, Disbrow GL, Simic V, Schlegel R. Are transforming properties of the bovine papillomavirus E5 protein shared by E5 from high-risk human papillomavirus type 16? Virology 2005;332(1):102-113.
Uren A, Toretsky JA. Pediatric malignancies provide unique cancer therapy targets. Curr Opin Pediatr 2005;17(1):14-19.
Uren A, Fallen S, Yuan H, Usubutun A, Kucukali T, Schlegel R, Toretsky JA. Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression. Cancer Res 2005;65(14):6199-6206.
Wang A, Gehan EA. Gene selection for microarray data analysis using principal component analysis. Stat Med 2005;24(13):2069-2087.
Henke RT, Maitra A, Paik S, and Wellstein A. Gene expression analysis in sections and tissue microarrays of archival tissues by mRNA in situ hybridization. Histol Histopathol 2005;20:225-237.
Jessup JM, Stewart A, Greene FL, Minsky BD. Adjuvant Chemotherapy for Stage III Colon Cancer: Implications of Ethnicity, Age and Differentiation. JAMA 2005;294:2703-2711.
Katuri V, Tang Y, Marshall B, Rashid A, Jogunoori W, Volpe EA, Sidawy AN, Evans S, Blay J, Gallicano GI, Premkumar Reddy E, Mishra L, Mishra B. Inactivation of ELF/TGF-beta signaling in human gastrointestinal cancer. Oncogene 2005;24(54):8012-24.
Kitlinska J, Abe K, Kuo L, Pons J, Yu M, Li L, Tilan J, Everhart L, Lee EW, Zukowska Z, Toretsky JA. Differential effects of neuropeptide Y on the growth and vascularization of neural crest-derived tumors. Cancer Res 2005;65:1719-28.
Malerczyk C, Schulte AM, Czubayko F, Bellon L, Macejak D, Riegel AT, Wellstein A. Ribozyme targeting of the growth factor pleiotrophin in established tumors: a gene therapy approach. Gene Ther 2005;12(4):339-346.
McDonnell K, Bowden ET, Cabal-Manzano R, Hoxter B, Riegel AT, and Wellstein A. Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors. Lab Invest 2005;85:747-755.
Mishra L, Derynck R, Mishra B. Transforming growth factor-beta signaling in stem cells and cancer. Science 2005;310(5745):68-71.
Mishra L, Katuri V, Evans S. The Role of PRAJA and ELF in TGF-beta Signaling and Gastric Cancer. Cancer Biol Ther 2005;4(7):694-9. Epub 2005 Jul 13.
Mishra L, and Roberts A. Role of TGF-β in stem cells and cancer. Oncogene Reviews 2005;24:5667.
Mishra L, Shetty K, Tang Y, Stuart A, Byers SW. The role of TGF-beta and Wnt signaling in gastrointestinal stem cells and cancer. Oncogene. 2005;24(37):5775-89. Review.
Redman S, Katuri V, Tang YI, Dillner A, Mishra B, Mishra L. Orofacial and gastrointestinal hyperplasia and neoplasia in Smad4+/- and elf+/-/Smad4+/- mutant mice. J Oral Pathol Med. 2005;3:23-9.
Stoica GE, Franke TF, Wellstein A, Morgan E, Czubayko F, List HJ, Reiter R, Martin MB, Stoica A. Heregulin-beta1 regulates the estrogen receptor-alpha gene expression and activity via the ErbB2/PI 3-K/Akt pathway. Oncogene 2005;24(11):1964.
Tang Y, Katuri V, Srinivasan R, Fogt F, Redman R, Anand G, Said A, Fishbein T, Zasloff M, Reddy EP, Mishra B, Mishra L. Transforming growth factor-beta suppresses nonmetastatic colon cancer through Smad4 and adaptor protein ELF at an early stage of tumorigenesis. Cancer Res 2005;65(10):4228-37.
Tilli MT, Reiter R, Oh AS, Henke RT, McDonnell K, Gallicano GI, Furth PA, and Riegel AT. Overexpression of an N-Terminally Truncated Isoform of the Nuclear Receptor Coactivator AIB1/ACTR Leads to Altered Proliferation of Mammary Epithelial Cells in Transgenic Mice*. Mol Endocrinol 2005;19(3):644-56.
Wang R, Li C, Xu X, Zheng Y, Xiao C, LeRoith D, Zerfa P, Eckhaus M, Mishra L, Deng C. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell (Metabolism) 2005;2:399-409.
Zukowska Z. Atherosclerosis and angiogenesis: what do nerves have to do with it? Pharmacol Rep. 2005;57 Suppl:229-34.
