Drug Discovery & Developmental Therapeutics Program
Overview | Leaders | Research | Publications | Activities
Selected Publications
2008
Alexandrescu DT, Popoveniuc G, Farzanmehr H, Dasanu CA, Dawson N, Wartofsky L. Sunitinib-associated lymphocytic thyroiditis without circulating antithyroid antibodies. Thyroid 2008;18(7):809-812.
Aslam S. Cardiovascular disease in dialysis patients: do some antihypertensive drugs have specific antioxidant effects or is it just blood pressure reduction? Does antioxidant treatment reduce the risk for cardiovascular disease? Curr Opin Nephrol Hypertens 2008;17(1):99-105.
Auerbach M, Goodnough LT, Picard D, Maniatis A. The role of intravenous iron in anemia management and transfusion avoidance. Transfusion 2008;48(5):988-1000.
Auerbach M, Al Talib K. Low-molecular weight iron dextran and iron sucrose have similar comparative safety profiles in chronic kidney disease. Kidney Int 2008;73(5):528-530.
Auerbach M, Ballard H. Intravenous iron in oncology. J Natl Compr Canc Netw 2008;6(6):585-592.
Auerbach M. Should intravenous iron be the standard of care in oncology? J Clin Oncol 2008;26(10):1579-1581.
Auerbach M, Ballard H. Intravenous iron as standard of care in oncology: opportunity lost. J Am Pharm Assoc (2003) 2008;48(4):455-457.
Auerbach M. Ferumoxytol as a new, safer, easier-to-administer intravenous iron: yes or no? Am J Kidney Dis 2008;52(5):826-829.
Auerbach M, Coyne D, Ballard H. Intravenous iron: from anathema to standard of care. Am J Hematol 2008;83(7):580-588.
Belle I, Hou L, Chen M, Steiner NK, Ng J, Hurley CK. Investigation of killer cell immunoglobulin-like receptor gene diversity in KIR3DL1 and KIR3DS1 in a transplant population. Tissue Antigens 2008;71(5):434-439.
Binyamin L, Alpaugh RK, Hughes TL, Lutz CT, Campbell KS, Weiner LM. Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy. J Immunol 2008;180(9):6392-6401.
Boersma MD, Sadowsky JD, Tomita YA, Gellman SH. Hydrophile scanning as a complement to alanine scanning for exploring and manipulating protein-protein recognition: application to the Bim BH3 domain. Protein Sci 2008;17(7):1232-1240.
Cartagena CM, Ahmed F, Burns MP, Pajoohesh-Ganji A, Pak DT, Faden AI, Rebeck GW. Cortical Injury Increases Cholesterol 24S Hydroxylase (Cyp46) Levels in the Rat Brain. J Neurotrauma 2008;25(9):1087-1098.
Cheever MA, Schlom J, Weiner LM, Lyerly HK, Disis ML, Greenwood A, Grad O, Nelson WG. Translational Research Working Group Developmental Pathway for Immune Response Modifiers. Clin Cancer Res 2008;14(18):5692-5699.
Chen K, Fallen S, Abaan HO, Hayran M, Gonzalez C, Wodajo F, MacDonald T, Toretsky JA, Uren A. Wnt10b induces chemotaxis of osteosarcoma and correlates with reduced survival. Pediatr Blood Cancer 2008;51:349-355.
Cheson BD. Recent developments in the treatment of CLL. Clin Adv Hematol Oncol 2008;6(5):6-8.
Cheson BD. Highlights of the 2008 international conference on malignant lymphoma. Clin Lymphoma Myeloma 2008;8(4):205-208.
Cheson BD, Leonard JP. Monoclonal antibody therapy for B-cell non-Hodgkin's lymphoma. N Engl J Med 2008;359(6):613-626.
Cheson BD. New response criteria for lymphomas in clinical trials. Ann Oncol 2008;19 Suppl 4:iv35-iv38.
Chinigo GM, Paige M, Grindrod S, Hamel E, Dakshanamurthy S, Chruszcz M, Minor W, Brown ML. Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity . J Med Chem 2008;51(15):4620-4631.
Clarke R, Ressom HW, Wang A, Xuan J, Liu MC, Gehan EA, Wang Y. The properties of high-dimensional data spaces: implications for exploring gene and protein expression data. Nat Rev Cancer 2008;8(1):37-49.
Cohen SJ, Alpaugh RK, Palazzo I, Meropol NJ, Rogatko A, Xu Z, Hoffman JP, Weiner LM, Cheng JD. Fibroblast activation protein and its relationship to clinical outcome in pancreatic adenocarcinoma. Pancreas 2008;37(2):154-158.
Cohen SJ, Engstrom PF, Lewis NL, Langer CJ, McLaughlin S, Beard M, Weiner LM, Meropol NJ. Phase I study of capecitabine and oxaliplatin in combination with the proteasome inhibitor bortezomib in patients with advanced solid tumors. Am J Clin Oncol 2008;31(1):1-5.
Dagata JA, Farkas N, Dennis CL, Shull RD, Hackley VA, Yang C, Pirollo KF, Chang EH. Physical characterization methods for iron-oxide contrast agents encapsulated within a targeted liposome-based delivery system. Nanotechnology 2008;19:305-316.
Deeken JF, Slack R, Marshall JL. Irinotecan and uridine diphosphate glucuronosyltransferase 1A1 pharmacogenetics: to test or not to test, that is the question. Cancer 2008;113(7):1502-1510.
Endo Y, Beauchamp E, Woods D, Taylor WG, Toretsky JA, Uren A, Rubin JS. Wnt-3a and Dickkopf-1 stimulate neurite outgrowth in Ewing tumor cells via a Frizzled3- and c-Jun N-terminal kinase-dependent mechanism. Mol Cell Biol 2008;28(7):2368-2379.
Fishbein T, Novitskiy G, Mishra L, Matsumoto C, Kaufman S, Goyal S, Shetty K, Johnson L, Lu A, Wang A, Hu F, Kallakury B, Lough D, Zasloff M. NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine. Gut 2008;57(3):323-330.
FitzGerald KT. Ethics at the intersection of pharmacoethnicity. Clin Pharmacol Ther 2008;84(3):424-426.
French CA, Ramirez CL, Kolmakova J, Hickman TT, Cameron MJ, Thyne ME, Kutok JL, Toretsky JA, Tadavarthy AK, Kees UR, Fletcher JA, Aster JC. BRD-NUT oncoproteins: a family of closely related nuclear proteins that block epithelial differentiation and maintain the growth of carcinoma cells. Oncogene 2008;27(15):2237-42.
Friedberg JW, Cohen P, Chen L, Robinson KS, Forero-Torres A, La Casce AS, Fayad LE, Bessudo A, Camacho ES, Williams ME, van der Jagt RH, Oliver JW, Cheson BD. Bendamustine in patients with rituximab-refractory indolent and transformed non-Hodgkin's lymphoma: results from a phase II multicenter, single-agent study. J Clin Oncol 2008;26(2):204-210.
Fuchs CS, Marshall JL, Barrueco J. Randomized, controlled trial of irinotecan plus infusional, bolus, or oral fluoropyrimidines in first-line treatment of metastatic colorectal cancer: updated results from the BICC-C study. J Clin Oncol 2008;26(4):689-690.
Gralow J, Ozols RF, Bajorin DF, Cheson BD, Sandler HM, Winer EP, Bonner J, Demetri GD, Curran W, Jr., Ganz PA, Kramer BS, Kris MG, Markman M, Mayer RJ, Raghavan D, Ramsey S, Reaman GH, Sawaya R, Schuchter LM, Sweetenham JW, Vahdat LT, Davidson NE, Schilsky RL, Lichter AS. Clinical cancer advances 2007: major research advances in cancer treatment, prevention, and screening--a report from the American Society of Clinical Oncology. J Clin Oncol 2008;26(2):313-325.
Halabi S, Vogelzang NJ, Kornblith AB, Ou SS, Kantoff PW, Dawson NA, Small EJ. Pain predicts overall survival in men with metastatic castration-refractory prostate cancer. J Clin Oncol 2008;26(15):2544-2549.
He AR, Lindenberg AP, Marshall JL. Biologic therapies for advanced pancreatic cancer. Expert Rev Anticancer Ther 2008;8(8):1331-1338.
He AR, Mendelson J, Blake T, Mishra L, Marshall JL. Stem cells in gastrointestinal cancers. Dis Markers 2008;24(4-5):217-222.
Hendee WR, Cleary K, Ehman RL, Fullerton GD, Grundfest WS, Haller J, Kelley CA, Meyer AE, Murphy RF, Phillips W, Torchilin VP. Bioengineering and imaging research opportunities workshop V: summary of findings on imaging and characterizing structure and function in native and engineered tissues. Radiology 2008;248(2):342-7.
Hilton GD, Stoica BA, Byrnes KR, Faden AI. Roscovitine reduces neuronal loss, glial activation, and neurologic deficits after brain trauma. J Cereb Blood Flow Metab 2008;28(11):1845-59.
Hou L, Steiner NK, Chen M, Belle I, Kubit AL, Ng J, Hurley CK. Limited allelic diversity of stimulatory two-domain killer cell immunoglobulin-like receptors. Hum Immunol 2008;69(3):174-178.
Hwang SH, Rait A, Pirollo KF, Zhou Q, Yenugonda VM, Chinigo GM, Brown ML, Chang EH. Tumor-targeting nanodelivery enhances the anticancer activity of a novel quinazolinone analogue. Mol Cancer Ther 2008;7(3):559-568.
Jbilou R, Amri H, Bouayad N, Ghailani N, Ennabili A, Sayah F. Insecticidal effects of extracts of seven plant species on larval development, alpha-amylase activity and offspring production of Tribolium castaneum (Herbst) (Insecta: Coleoptera: Tenebrionidae). Bioresour Technol 2008;99(5):959-964.
Ji Y, Shah S, Soanes K, Islam MN, Hoxter B, Biffo S, Heslip T, Byers S. Eukaryotic initiation factor 6 selectively regulates Wnt signaling and beta-catenin protein synthesis. Oncogene 2008;27(6):755-62.
Jonklaas J, Davidson B, Bhagat S, Soldin SJ. Triiodothyronine levels in athyreotic individuals during levothyroxine therapy. JAMA 2008;299(7):769-777.
Jonklaas J, Nsouli-Maktabi H, Soldin SJ. Endogenous thyrotropin and triiodothyronine concentrations in individuals with thyroid cancer. Thyroid 2008;18(9):943-952.
Kaufman HL, Lenz HJ, Marshall J, Singh D, Garett C, Cripps C, Moore M, von Mehren M, Dalfen R, Heim WJ, Conry RM, Urba WJ, Benson AB, III, Yu M, Caterini J, Kim-Schulze S, Debenedette M, Salha D, Vogel T, Elias I, Berinstein NL. Combination chemotherapy and ALVAC-CEA/B7.1 vaccine in patients with metastatic colorectal cancer. Clin Cancer Res 2008;14(15):4843-4849.
Lazaro AM, Xiao Y, Masaberg C, Lebeck L, Ng J, Hurley CK, Posch PE. Novel alleles at the HLA-DRB1 and -DQB1 loci. Tissue Antigens 2008;72:72-4.
Lazaro AM, Xiao Y, Cao K, Masaberg C, Nichol L, Ng J, Hurley CK, Posch PE. Twenty-three novel alleles increase diversity at the HLA-C locus. Tissue Antigens 2008;71:560-3.
Lazaro AM, Xiao Y, Cao K, Masaberg C, Nichol L, Ng J, Hurley CK, Posch PE. Expanding diversity at the HLA-B locus: 28 novel HLA-B alleles. Tissue Antigens 2008;71(5):471-474.
Lekostaj JK, Amoah LE, Roepe PD. A single S1034C mutation confers altered drug sensitivity to PfMDR1 ATPase activity that is characteristic of the 7G8 isoform. Mol Biochem Parasitol 2008;157(1):107-111.
Mao D, Perry DC, Yasuda RP, Wolfe BB, Kellar KJ. The alpha4beta2alpha5 nicotinic cholinergic receptor in rat brain is resistant to up-regulation by nicotine in vivo. J Neurochem 2008;104(2):446-456.
Marshall JL. Managing potentially resectable metastatic colon cancer. Gastrointestinal Cancer Research 2008;2:S20-S23.
Mi L, Xiao Z, Hood BL, Dakshanamurthy S, Wang X, Govind S, Conrads TP, Veenstra TD, Chung FL. Covalent binding to tubulin by isothiocyanates. A mechanism of cell growth arrest and apoptosis. J Biol Chem 2008;283(32):22136-22146.
Mishra B, Gearhart J, He AR, Mendelson J, Blake T, Mishra L, Marshall JL. Stem cells in gastrointestinal cancers. Markers 2008;24(4/5):217-222.
Mocchetti I, Brown M. Targeting neurotrophin receptors in the central nervous system. CNS Neurol Disord Drug Targets 2008;7(1):71-82.
Morgan NP, Graves KD, Poggi EA, Cheson BD. Implementing an expressive writing study in a cancer clinic. Oncologist 2008;13(2):196-204.
Moussa CE, Mahmoodian F, Tomita Y, Sidhu A. Dopamine differentially induces aggregation of A53T mutant and wild type alpha-synuclein: insights into the protein chemistry of Parkinson's disease. Biochem Biophys Res Commun 2008;365(4):833-839.
Mulrooney TJ, Hou L, Steiner NK, Chen M, Belle I, Ng J, Hurley CK. Promoter variants of KIR2DL5 add to diversity and may impact gene expression. Immunogenetics 2008;60(6):287-294.
Murray JK, Sadowsky JD, Scalf M, Smith LM, Tomita Y, Gellman SH. Exploration of structure--activity relationships among foldamer ligands for a specific protein binding site via parallel and split-and-mix library synthesis. J Comb Chem 2008;10(2):204-215.
Niedringhaus M, Jackson PG, Evans SR, Verbalis JG, Gillis RA, Sahibzada N. Dorsal Motor Nucleus of the Vagus: A site for evoking simultaneous changes in crural diaphragm activity, lower esophageal sphincter pressure and fundus tone. Am J Physiol Regul Integr Comp Physiol 2008;294(1):R121-31.
Oh AS, Lahusen JT, Chien CD, Fereshteh MP, Zhang X, Dakshanamurthy S, Xu J, Kagan BL, Wellstein A, Riegel AT. Tyrosine phosphorylation of the nuclear receptor coactivator AIB1/SRC-3 is enhanced by Abl kinase and is required for its activity in cancer cells. Mol Cell Biol 2008;28(21):6580-93.
Onozato ML, Tojo A, Leiper J, Fujita T, Palm F, Wilcox CS. Expression of NG,NG-dimethylarginine dimethylaminohydrolase and protein arginine N-methyltransferase isoforms in diabetic rat kidney: effects of angiotensin II receptor blockers. Diabetes 2008;57(1):172-180.
Palm F, Connors SG, Mendonca M, Welch WJ, Wilcox CS. Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats. Hypertension 2008;51(2):345-351.
Pirollo KF, Rait A, Zhou Q, Zhang XQ, Zhou J, Kim CS, Benedict WF, Chang EH. Tumor-targeting nanocomplex delivery of novel tumor suppressor RB94 chemosensitizes bladder carcinoma cells in vitro and in vivo. Clin Cancer Res 2008;14(7):2190-2198.
Pirollo KF, Chang EH. Does a targeting ligand influence nanoparticle tumor localization or uptake?. Trends Biotechnol 2008;26(10):552-558.
Pirollo KF, Chang EH. Targeted delivery of small interfering RNA: approaching effective cancer therapies. Cancer Res 2008;68(5):1247-1250.
Pons J, Kitlinska J, Jacques D, Perreault C, Nader M, Everhart L, Zhang Y, Zukowska Z. Interactions of multiple signaling pathways in neuropeptide Y-mediated bimodal vascular smooth muscle cell growth. Can J Physiol Pharmacol 2008;86(7):438-448.
Robinson KS, Williams ME, van der Jagt RH, Cohen P, Herst JA, Tulpule A, Schwartzberg LS, Lemieux B, Cheson BD. Phase II Multicenter Study of Bendamustine Plus Rituximab in Patients With Relapsed Indolent B-Cell and Mantle Cell Non-Hodgkin's Lymphoma. J Clin Oncol 2008;26(27):4473-9.
Rodgers GM, Auerbach M, Cella D, Chertow GM, Coyne DW, Glaspy JA, Henry DH. High-molecular weight iron dextran: a wolf in sheep's clothing? J Am Soc Nephrol 2008;19(5):833-834.
Sacchi N, Costeas P, Hartwell L, Hurley CK, Raffoux C, Rosenmayr A, Greinix H. Haematopoietic stem cell donor registries: World Marrow Donor Association recommendations for evaluation of donor health. Bone Marrow Transplant 2008;42(1):9-14.
Saha DT, Davidson BJ, Wang A, Pollock AJ, Orden RA, Goldman R. Quantification of DNA repair capacity in whole blood of patients with head and neck cancer and healthy donors by comet assay. Mutat Res 2008;650(1):55-62.
Seiboth L, Van Nostrand D, Wartofsky L, Ousman Y, Jonklaas J, Butler C, Atkins F, Burman K. Utility of PET/neck MRI digital fusion images in the management of recurrent or persistent thyroid cancer. Thyroid 2008;18(2):103-111.
Shan X, Xiao Y, Wang L, Lazaro AM, Hurley CK. Identification of 11 novel HLA alleles found during typing of unrelated registry donors in China. Tissue Antigens 2008;71:578-9.
Simkus C, Makiya M, Jones JM. Karyopherin alpha 1 is a putative substrate of the RAG1 ubiquitin ligase. Molecular Immunology 2008 Dec 30 [Epub ahead of print].
Sissung TM, Baum CE, Deeken J, Price DK, Aragon-Ching J, Steinberg SM, Dahut W, Sparreboom A, Figg WD. ABCB1 genetic variation influences the toxicity and clinical outcome of patients with androgen-independent prostate cancer treated with docetaxel. Clin Cancer Res 2008;14(14):4543-4549.
Steiner NK, Dakshanamurthy S, Vandenbussche CJ, Hurley CK. Extracellular domain alterations impact surface expression of stimulatory natural killer cell receptor KIR2DS5. Immunogenetics 2008;60(11):655-67.
Tang Y, Kitisin K, Jogunoori W, Li C, Deng CX, Mueller SC, Ressom HW, Rashid A, He AR, Mendelson JS, Jessup JM, Shetty K, Zasloff M, Mishra B, Reddy EP, Johnson L, Mishra L. Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling. Proc Natl Acad Sci U S A 2008;105(7):2445-2450.
Toscano CD, Ueda Y, Tomita YA, Vicini S, Bosetti F. Altered GABAergic neurotransmission is associated with increased kainate-induced seizure in prostaglandin-endoperoxide synthase-2 deficient mice. Brain Res Bull 2008;75(5):598-609.
VandenBussche CJ, Mulrooney TJ, Frazier WR, Dakshanamurthy S, Hurley CK. Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule. Genes Immun 2008 Nov 13. [Epub ahead of print]
Veselik DJ, Divekar S, Dakshanamurthy S, Storchan GB, Turner JM, Graham KL, Huang L, Stoica A, Martin MB. Activation of estrogen receptor-alpha by the anion nitrite. Cancer Res 2008;68(10):3950-3958.
Wang D, Strandgaard S, Borresen ML, Luo Z, Connors SG, Yan Q, Wilcox CS. Asymmetric dimethylarginine and lipid peroxidation products in early autosomal dominant polycystic kidney disease. Am J Kidney Dis 2008;51(2):184-191.
Weiner LM. Monoclonal antibodies have emerged as versatile and useful cancer therapeutics. Cancer J 2008;14(3):147-148.
Weiner LM. Cancer immunotherapy--the endgame begins. N Engl J Med 2008;358(25):2664-2665.
Weiner LM, Belldegrun AS, Crawford J, Tolcher AW, Lockbaum P, Arends RH, Navale L, Amado RG, Schwab G, Figlin RA. Dose and schedule study of panitumumab monotherapy in patients with advanced solid malignancies. Clin Cancer Res 2008;14(2):502-508.
Wieghaus KA, Gianchandani EP, Paige MA, Brown ML, Botchwey EA, Papin JA. Novel pathway compendium analysis elucidates mechanism of pro-angiogenic synthetic small molecular. Bioinformatics 2008;24:2384-2390.
Wieghaus KA, Nickerson MM, Petrie Aronin CE, Sefcik LS, Price RJ, Paige MA, Brown ML, Botchwey EA. Expansion of microvascular networks/in vivo/by phthalimide neovascular factor 1 (PNF1). Biomaterials 2008;29:4698-4708.
Williams TM, Winden T, Setterholm M, Vierra-Green CA, Spellman S, Flesch S, Awdeh Z, Baxter-Lowe LA, Begovich AB, Fernandez-Vina M, Hegland J, Hurley CK, Johnson D, Noreen H, Salazar M, Schmeckpeper B, Yunis EJ. Strategies and technical challenges in allele level Class II typing in 2578 bone marrow transplantation donor-recipient pairs. Hum Immunol 2008;69(4-5):227-234.
Yang C, Rait A, Pirollo KF, Dagata JA, Farkas N, Chang EH. Nanoimmunoliposome delivery of superparamagnetic iron oxide markedly enhances targeting and uptake in human cancer cells in vitro and in vivo. Nanomedicine 2008;4(4):318-29.
Zhang C, Crasta O, Cammer S, Will R, Kenyon R, Sullivan D, Yu Q, Sun W, Jha R, Liu D, Xue T, Zhang Y, Moore M, McGarvey P, Huang H, Chen Y, Zhang J, Mazumder R, Wu C, Sobral B. An emerging cyberinfrastructure for biodefense pathogen and pathogen host data. Nucleic Acids Res 2008;36(Database issue):D884-91.
