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Home » Research

Breast Cancer Research

Selected publications

2007 2006 Earlier Publications

2007

  • Jiang S., Li P., Lee S..L, Lin C.Y., Long Y.Q., Johnson M.D., Dickson R.B., Roller P.P. (2007) Design and synthesis of redox stable analogues of sunflower trypsin inhibitors (SFTI-1) on solid support, potent inhibitors of matriptase. Org Lett. 9:9-12. 

  • Kessler CK, Khokhar N, and Liu M. A systematic approach to the bleeding patient: correlation of clinical symptoms and signs with laboratory testing. In: Kitchens CS, Alving BM, and Kessler CK, ed. Consultative Hemostasis and Thrombosis, 2nd edition. In press.

  • Shajahan AN, Wang A, Decker M, Minshall RD, Liu MC, and Clarke R. Caveolin-1 tyrosine phosphorylation enhances paclitaxel-mediated cytotoxicity. J Biol Chem. 2007. In press.

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2006

  • Artym, V. V., Y. Zhang, F. Seillier-Moiseiwitsch, K. M. Yamada, and S. C. Mueller. 2006. Dynamic interactions of cortactin and membrane type 1 matrix metalloproteinase at invadopodia: defining the stages of invadopodia formation and function. Cancer Res 66:3034-3043.

  • Blancato, JK, Williams MS, and Dickson, RB.  2006. Fluorescence in situ hybridization assessment of c-myc gene amplification in breast tumor tissues. Methods Mol Med 120:297-307.

  • Bouker, K.B., Skaar, T.C., Harburger, D.S., Riggins, R.B., Fernandez, D.R., Zwart, A. & Clarke, R. “The A4396G polymorphism in interferon regulatory factor-1 is frequently expressed in breast cancer.” Cancer Genet Cytogenet, in press.

  • Bowden, E. T., E. Onikoyi, R. Slack, A. Myoui, T. Yoneda, K. M. Yamada, and S. C. Mueller. 2006. Co-localization of cortactin and phosphotyrosine identifies active invadopodia in human breast cancer cells. Exp.Cell Res 312:1240-1253.

  • Briones, V. R., S. Chen, A. T. Riegel, and R. J. Lechleider. 2006. Mechanism of fibroblast growth factor-binding protein 1 repression by TGF-beta. Biochem.Biophys.Res Commun. 345:595-601.

  • Coopman,P.J. and Mueller,S.C. (2006). The Syk tyrosine kinase: a new negative regulator in tumor growth and progression. Cancer Letters Jan 25; [Epub ahead of print].

  • Creighton CJ, Cordero KE, Larios JM, Miller RS, Johnson MD, Chinnaiyan AM, Lippman ME, Rae JM. (2006) Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors. Genome Biol. 2006 Apr 7;7(4):R28 [Epub ahead of print]

  • de Assis, S, SG, Khan, and Hilakivi-Clarke, L. 2006. High birth weight increases mammary tumorigenesis in rats. Int J Cancer 119:1537-1546.

  • de Assis, S, Wang, M. Goel, S, Foxworth, A, Helferich, W and Hilakivi-Clarke, L. 2006. Excessive weight gain during pregnancy increases carcinogen-induced mammary tumorigenesis in Sprague-Dawley and lean and obese Zucker rats. J Nutr 136:998-1004.

  • Graves, K. D., B. N. Peshkin, C. H. Halbert, T. A. Demarco, C. Isaacs, and M. D. Schwartz. 2006. Predictors and outcomes of contralateral prophylactic mastectomy among breast cancer survivors. Breast Cancer Res Treat.

  • De Clerck, Y., Weissman, B.E., Yu, D., Parsons, R., Bar-Eli, M., Roy-Burman, P., Seewaldt, V.L.,  Cress, A.E., Languino, L.R., Batra, S.K. Tang, C.K., Sheng, S., Chen, W.-T., Chellappan, S.,  Cheng, S.-Y., Ladisch, S., McCarthy, J.B., Coussens, L.M. & Cohen,M.B. Tumor Progression and Metastasis from Genetic to Microenvironmental Determinants”. Cancer Biology & Therapy,  Dec. 5(12); 2006.

  • Creighton,C.J.; Cordero,K.E.; Larios,J.M.; Miller,R.S.; Johnson,M.D.; Chinnaiyan,A.M.; Lippman,M.E.; Rae,J.M. (2006)  Genes regulated by estrogen in breast tumor cells in vitro are similarly regulated in vivo in tumor xenografts and human breast tumors.  Genome Biol. 2006 Apr 7;7(4):R28

  • Dilmanian FA, Zhong Z, Bacarian T, Benveniste H, Romanelli P, Wang R, Welwart J, Yuasa T, Rosen EM, Anschell DJ.  Interlaced X-ray microplanar arrays: A novel radiosurgery approach with clinical potential.  Proc Natl Acad Sci USA 103: 9709-9714, 2006.

  • Fan S, Meng Q, Laterra JJ, Rosen EM.  Ras effector pathways modulate scatter factor-stimulated NF-kB signaling and protection against DNA damage.  Oncogene, In press.

  • Fan, S., Q. Meng, K. Auborn, T. Carter, and E. M. Rosen. 2006. BRCA1 and BRCA2 as molecular targets for phytochemicals indole-3-carbinol and genistein in breast and prostate cancer cells. Br J Cancer 94:407-426.

  • Feng, Y., Wang, Z., Zhu, Y., Xuan, J., Miller, D., Clarke, R., Hoffman, E.P. & Wang, Y. “Learning the tree of phenotypes using genomic data and VISDA.” 6th IEEE Symp Bioinf Bioeng (BIBE ’06), 165-170, 2006

  • Fricke, S. T., O. Rodriguez, J. Vanmeter, L. E. Dettin, M. Casimiro, C. D. Chien, T. Newell, K. Johnson, L. Ileva, J. Ojeifo, M. D. Johnson, and C. Albanese. 2006. In vivo magnetic resonance volumetric and spectroscopic analysis of mouse prostate cancer models. Prostate 66:708-717.

  • Furth, P. A. and E. D. Halama. 2006. What do shifts in indicators of apoptosis indicate about the cancer process? J Nutr 136:2700S-2703S.

  • Gong, T., Xuan, J., Zhu, J., Li, H., Clarke, R. E. Hoffman and Y. Wang, “Composite gene module discovery using non-negative independent component analysis.” IEEE/NLM Life Sci Sys Apps Workshop, in press.

  • Han, W., T. Zhang, H. Yu, J. G. Foulke, and C. K. Tang. 2006. Hypophosphorylation of Residue Y1045 Leads to Defective Downregulation of EGFRvIII. Cancer Biol Ther. , Oct 26;5(10), 2006.

  • Henke, R. T., K. S. Eun, A. Maitra, S. Paik, and A. Wellstein. 2006. Expression analysis of mRNA in formalin-fixed, paraffin-embedded archival tissues by mRNA in situ hybridization. Methods 38:253-262.

  • Hilakivi-Clarke, L. and S. de Assis. 2006. Fetal origins of breast cancer. Trends Endocrinol.Metab 17:340-348.

  • Hilakivi-Clarke, L., A. Shajahan, B. Yu, and S. de Assis. 2006. Differentiation of mammary gland as a mechanism to reduce breast cancer risk. J Nutr 136:2697S-2699S.

  • Ingeholm, M. L., I. K. Mun, and S. K. Mun. 2006. RFID in healthcare. J AHIMA. 77:56-8, 61, 63.

  • Jiang, X., E. Rosen, T. Zeffiro, J. Vanmeter, V. Blanz, and M. Riesenhuber. 2006. Evaluation of a shape-based model of human face discrimination using FMRI and behavioral techniques. Neuron 50:159-172.

  • Kang, H. J., H. J. Kim, S. K. Kim, R. Barouki, C. H. Cho, K. K. Khanna, E. M. Rosen, and I. Bae. 2006. BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. J Biol Chem 281:14654-14662.

  • Katiyar, P., Y. Ma, S. Fan, R. G. Pestell, P. A. Furth, and E. M. Rosen. 2006. Regulation of progesterone receptor signaling by BRCA1 in mammary cancer. Nucl.Recept.Signal 4:e006.

  • Kiyomiya KI, Lee MS, Tseng IC, Zuo H, Barndt RJ, Johnson MD, Dickson RB and Lin CY. (2006) Matriptase activation and subsequent shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells Am.J.Physiol Cell Physiol 291:C40-C49.

  • Kotsopoulos J, Lubinski J, Neuhausen SL, Lynch HT, Rosen B, Ainsworth P, Moller P, Ghadirian P, Isaacs C, Karlan B, Sun P, Narod SA. Hormone replacement therapy and the risk of ovarian cancer in BRCA1 and BRCA2 mutation carriers. Gynecol Oncol. 2006;100:83-8.

  • Kuchulakanti, P. K., W. W. Chu, R. Torguson, P. Ohlmann, S. W. Rha, L. C. Clavijo, S. W. Kim, A. Bui, N. Gevorkian, Z. Xue, K. Smith, J. Fournadjieva, W. O. Suddath, L. F. Satler, A. D. Pichard, K. M. Kent, and R. Waksman. 2006. Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stents. Circulation 113:1108-1113.

  • Kuo, A. H., G. E. Stoica, A. T. Riegel, and A. Wellstein. 2006. Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase. Oncogene.

  • Kuske, B., Naughton, C., Moore, K., MacLeod, K.G., Miller, W.R., Clarke, R. Langdon, S.P. & Cameron, D.A. “Endocrine therapy resistance can be associated with high estrogen receptor alpha (ERα) expression and reduced ERα phosphorylation in breast cancer models.” Endocr Related Cancer, 13: 1121-1133, 2006.Lehnes, K., A. D. Winder, C. Alfonso, N. Kasid, M. Simoneaux, H. Summe, E. Morgan, M. C. Iann, J. Duncan, M. Eagan, R. Tavaluc, C. H. Evans, Jr., R. Russell, A. Wang, F. Hu, and A. Stoica. 2006. THE EFFECT OF ESTRADIOL ON IN VIVO TUMORIGENESIS IS MODULATED BY THE ErbB2/PI 3-K/Akt1 PATHWAY. Endocrinology.

  • Liu MC and Isaacs CJD. Adjuvant Systemic Therapy. In: Spear S, Willey SC, Robb GL, Hammond DC, and Nahabedian MY, eds. Surgery of the Breast: Principles and Art, 2nd edition. Baltimore: Lippincott Williams & Wilkins. 2006.

  • Liu, M. L., B. Kallakury, C. Kessler, D. P. Hartmann, N. Azumi, and M. Ozdemirli. 2006. Chronic idiopathic myelofibrosis terminating in extramedullary anaplastic plasmacytoma. Leuk.Lymphoma 47:315-322.

  • Ma, Y., P. Katiyar, L. P. Jones, S. Fan, Y. Zhang, P. A. Furth, and E. M. Rosen. 2006. The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. Mol Endocrinol. 20:14-34.

  • Ma, Y., R. Q. Yuan, S. Fan, C. Hu, I. D. Goldberg, J. J. Laterra, and E. M. Rosen. 2006. Identification of genes that modulate sensitivity of U373MG glioblastoma cells to cis-platinum. Anticancer Drugs 17:733-751.

  • Mani, A., A. S. Oh, E. T. Bowden, T. Lahusen, K. L. Lorick, A. M. Weissman, R. Schlegel, A. Wellstein, and A. T. Riegel. 2006. E6AP Mediates Regulated Proteasomal Degradation of the Nuclear Receptor Coactivator Amplified in Breast Cancer 1 in Immortalized Cells. Cancer Res 66:8680-8686.

  • Modlinger, P., T. Chabrashvili, P. S. Gill, M. Mendonca, D. G. Harrison, K. K. Griendling, M. Li, J. Raggio, A. Wellstein, Y. Chen, W. J. Welch, and C. S. Wilcox. 2006. RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Hypertension 47:238-244.

  • Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FR, Fevr T, Clark L, Bayani1 N, Coppe J-P, Tong F, Speed T, Spellman PT, Devries S, Lapuk A, Kuo W-L, Stilwell JL, Pinkel D, Albertson DG, Waldman  FM, McCormick F, Dickson RB, Johnson MD, Lippman M, Ethier S, Gazdar A, and Gray JW. (2006) A breast cancer cell line “system” for functional cancer genomics. Cancer Cell 10:515-527.

  • Nkondjock A, Ghadirian P, Kotsopoulos J, Lubinski J, Lynch H, Kim-Sing C, Horsman D, Rosen B, Isaacs C, Weber B, Foulkes W, Ainsworth P, Tung N, Eisen A, Friedman E, Eng C, Sun P, Narod SA. Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. Int J Cancer. 2006;118:103-7

  • Pirollo, K. F., J. Dagata, P. Wang, M. Freedman, A. Vladar, S. Fricke, L. Ileva, Q. Zhou, and E. H. Chang. 2006. A tumor-targeted nanodelivery system to improve early MRI detection of cancer. Mol Imaging 5:41-52.

  • Pretner, E., H. Amri, W. Li, R. Brown, C. S. Lin, E. Makariou, F. V. Defeudis, K. Drieu, and V. Papadopoulos. 2006. Cancer-related overexpression of the peripheral-type benzodiazepine receptor and cytostatic anticancer effects of Ginkgo biloba extract (EGb 761). Anticancer Res 26:9-22.

  • Rae JM, Creighton CJ, Meck JM, Haddad BR, and Johnson MD. (2006) MDA-MB-435 cells are derived from M14 Melanoma cells - a loss for breast cancer, but a boon for melanoma research. Breast Can. Res. Treat. (in press).

  • Rae JM, Johnson MD, Cordero KE, Scheys JO, Larios JM, Gottardis MM, Pienta KJ and Lippman ME.  (2006)  GREB1 is a Novel Androgen Regulated Gene Required for Prostate Cancer Growth.   Prostate 66:866-94.

  • Ray, P. E., E. Tassi, X. H. Liu, and A. Wellstein. 2006. Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome. Am J Physiol Regul.Integr.Comp Physiol 290:R105-R113.

  • Ressom, H.W., Zhang, Y.,  Xuan, J., Wang, Y. & Clarke, R. “Inference of gene regulatory networks from time course gene expression data using neural networks and swarm intelligence.” IEEE Symp Compl Intel Bioinf Comput Biol, 435-442, 2006.

  • Riggins RB, Thomas KS, Ta HQ, Donelan SS, Owen KA, Gibson MA, Shupnik MA, Silva CM, Parsons SJ, Clarke R & Bouton AH. “Physical and functional interactions between Cas and c-Src induce tamoxifen resistance of breast cancer cells through pathways involving EGFR and STAT5b.” Cancer Res, 66: 7007-7015, 2006.

  • Rodriguez O, Fricke S, Chien C, Dettin L, Vanmeter J, Shapiro E, Dai HN, Casimiro M, Ileva L, Dagata J, Johnson MD, Lisanti MP, Koretsky A, and Albanese C. 2006. Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI. Cell Cycle 5:113-119.

  • Rosen EM, Fan S and Ma Y. 2006. BRCA1 regulation of transcription. Cancer Lett. 236:175-185.

  • Rosen EM, Fan S, Ma Y, Levin ER.  Regulation of plasma membrane ER in breast cancer.  Invited Review.  Breast Cancer Online, 2006 [Published online in 2006].

  • Sabbatini, P., J. Dupont, C. Aghajanian, F. Derosa, E. Poynor, S. Anderson, M. Hensley, P. Livingston, A. Iasonos, D. Spriggs, W. McGuire, S. Reinartz, S. Schneider, C. Grande, S. Lele, K. Rodabaugh, J. Kepner, S. Ferrone, and K. Odunsi. 2006. Phase I study of abagovomab in patients with epithelial ovarian, fallopian tube, or primary peritoneal cancer. Clin Cancer Res 12:5503-5510.

  • Shajahan, A., Wang, A., Decker, M., Minshall, R.D., Liu, M.C. & Clarke, R. “Caveolin-1 tyrosine phosphorylation (Y14) enhances paclitaxel-mediated cytotoxicity.” J Biol Chem, in press.

  • Spear, S. L. 2006. Discussion. Plast.Reconstr.Surg 118:15S-17S.

  • Spear, S. L., E. J. Bulan, and M. L. Venturi. 2006. Breast augmentation. Plast.Reconstr.Surg 118:188S-196S.

  • Spear, S. L., D. P. Bogue, and J. M. Thomassen. 2006. Synmastia after breast augmentation. Plast.Reconstr.Surg 118:168S-171S.

  • Spear, S. L., J. H. Boehmler, and M. W. Clemens. 2006. Augmentation/Mastopexy: A 3-Year Review of a Single Surgeon's Practice. Plast.Reconstr.Surg 118:136S-147S.

  • Sridhar J, Pattabiraman N, Rosen EM, Pestell RG.  CDK inhibitors as anticancer agents: Perspectives for the future.  CRC Press, In press.

  • Subramaniam, D. S. and C. Isaacs. 2006. Does prophylactic surgery reduce the risk of gynecologic cancers arising from the Lynch syndrome? Nat.Clin Pract Oncol 3:426-427.

  • Tassi, E., R. T. Henke, E. T. Bowden, M. R. Swift, D. P. Kodack, A. H. Kuo, A. Maitra, and A. Wellstein. 2006. Expression of a fibroblast growth factor-binding protein during the development of adenocarcinoma of the pancreas and colon. Cancer Res 66:1191-1198.

  • Torguson, R., M. Sabate, R. Deible, K. Smith, W. W. Chu, K. M. Kent, A. D. Pichard, W. O. Suddath, L. F. Satler, and R. Waksman. 2006. Intravascular brachytherapy versus drug-eluting stents for the treatment of patients with drug-eluting stent restenosis. Am J Cardiol. 98:1340-1344.

  • Trock, B.J., Hilakivi-Clarke, L.A. & Clarke, R. “Meta-analysis of soy intake and breast cancer risk.” J Natl Cancer Inst, 98: 459-471, 2006.

  • Wang, L.H., Yang, X.Y., Zhang, X., An, P., Kim, H.-J., Huang, J., Clarke, R., Osborne, C.K., Inman, J.K., Appella, E. & Farrar, W.L. “Disruption of estrogen receptor DNA-binding domain and related intramolecular communication restores tamoxifen sensitivity in resistant breast cancer.” Cancer Cell, 10: 487-499, 2006.

  • Wang, Z., Wang, Y., Xuan, J., Dong, Y., Bakay, M., Khan, J., Clarke, R. & Hoffman, E.P. “Optimized multilayer perceptrons for molecular classification and diagnosis using genomic data.” Bioinformatics, 22: 755-761, 2006.

  • Whitney, A. T. and R. Clarke. 2006. Robert B. Dickson: in memoriam (1952-2006). Cancer Res 66:11514.

  • Wong, L.-J.C., Dai, P., Lu, J.-F., Lou, M.A., Clarke, R. & Nazarov, N. “AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines.” BMC Cancer 6: 111-132, 2006.

  • Wu, C. H., R. Apweiler, A. Bairoch, D. A. Natale, W. C. Barker, B. Boeckmann, S. Ferro, E. Gasteiger, H. Huang, R. Lopez, M. Magrane, M. J. Martin, R. Mazumder, C. O'Donovan, N. Redaschi, and B. Suzek. 2006. The Universal Protein Resource (UniProt): an expanding universe of protein information. Nucleic Acids Res 34:D187-D191.

  • Xie, B., E. Tassi, M. R. Swift, K. McDonnell, E. T. Bowden, S. Wang, Y. Ueda, Y. Tomita, A. T. Riegel, and A. Wellstein. 2006. Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display. J Biol Chem 281:1137-1144.

  • Xu, J., M. Gao, S. Fan, Q. Meng, I. D. Goldberg, R. Abounader, H. Ressom, J. J. Laterra, and E. M. Rosen. 2006. Effect of Akt inhibition on scatter factor-regulated gene expression in DU-145 human prostate cancer cells. Oncogene.

  • Yu, B., G. Khan, A. Foxworth, K. Huang, and L. Hilakivi-Clarke. 2006. Maternal dietary exposure to fiber during pregnancy and mammary tumorigenesis among rat offspring. Int J Cancer 119:2279-2286.

  • Yuan H, Ghim S, Newsome J, Apolinario T, Olcese V, Martin M, Delius H, Felsburg P, Jenson B, and Schlegel R. 2006. An epidermotropic canine papillomavirus with malignant potential contains an E5 gene and establishes a unique genus. Virology.

  • Zhu Y, Singh B, Hewitt S, Liu A, Gomez B, Wang A, Clarke R. Expression patterns among interferon regulatory factor-1, human X-box binding protein-1, nuclear factor kappa B, nucleophosmin, estrogen receptor-alpha and progesterone receptor proteins in breast cancer tissue microarrays. Int J Oncol. 2006;28:67-76.

  • Zhu, Y, Wang A, Liu MC, Zwart A, Lee RY, Gallagher A, Wang Y, Miller WR, Dixon JM, and Clarke R. 2006. Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures. Int J Oncol 29:1581-1589.

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Earlier Publications

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