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Molecular Targets and Developmental Therapeutics

SELECTED PUBLICATIONS

Abu-Ghosh, A., Bracho, F., Kirov, I., and Cairo, M.S. Hematopoietic colony stimulating factors. In W. Shoemaker, S.M. Ayers, A. Grenvik, and P.R. Holbrook (eds.), Textbook of Critical Care, 4th ed Philadelphia: WB Saunders, Co., 2000.

Abu-Ghosh, A., Goldman, S., Krailo, M., Rimm, I., Davenport, G., Morris, E., Laver, J., Reaman, G., and Cairo, M. Excellent response (91%) to ifosfamide, carboplatin, and etoposide in children with relapsed Wilm's tumor. Ann. Oncology, 13: 560-569, 2002.

Aigner, A., Ray, P., Czubayko, F., and Wellstein, A. Immunolocalization of an FGF binding protein reveals a widespread expression pattern during different stages of mouse embryo development. Histochem.Cell Biol., 117: 1-11, 2002.

Allen, J.W., Eldadah, B.A., Huang, X., Knoblach, S., and Faden, A.I. Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis. J.Neurosci.Res., 65: 45-53, 2001.

Allen, J.W., Knoblach, S., and Faden, A.I. Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro. Cell Death.Diff., 7: 470-476, 2000.

Andrews, J., Djakiew, D., Krygier, S., and Andrews, P. Superior effectiveness of ibuprofen compared with other NSAIDs for reducing the survival of human prostate cancer cells. Cancer Chemother.Pharmacol., 50: 277-84, 2002.

Arlen, P., Tsang, K., Marshall, J.L., Chen, A., Steinberg, S.M., Poole, D., Hand, P.H., Schlom, J., and Hamilton, J.M. The use of a rapid ELISPOT assay to analyze peptide-specific immune response in carcinoma patinets to peptide vs. recombinant paxvirus vaccines. Cancer Immunol. Immunother., 49: 517-529, 2000.

Baidas, S., Tfayli, A., and Bhargava, P. Thalidomide: an old drug with new clinical applications. Cancer Invest., 20: 835-848, 2002.

Baidas, S., Winer, E., Fleming, G., Harris, L., Pluda, J.M., Crawford, J., Yamauchi, H., Isaacs, C., Hanfelt, J., Tefft, M.C., Flockhart, D. A., Johnson, M.D., Hawkins, M.J., Lippman, M., and Hayes, D.F. Phase II evaluation of thalidomide in patients with metastatic breast cancer. J.Clin.Oncol., 18: 2710-2717, 2000.

Bansal, R., Chen, H.X., Marshall, J.L., Tan, J., Glazer, R.I., and Wainer, I.W. Detection of a mixed-backbone oligonucleotide (GEM231) in liver and tumor tissues by capillary electrophoresis. J.Chromatogr.Biomed.Sci.Appl., 750: 129-135, 2001.

Belmant, C., Espinosa, E., Halary, F., Tang, Y., Peyrat, M.-A., Sicard, H., Kozikowski, A.P., Buelow, R., Poupot, R., Bonneville, M., and Fournie, J.-J. A chemical basis for selective recognition of nonpeptide antigens by human delta-T cells. FASEB J., 14: 1669-1670, 2000.

Benaud, C., Oberst, M., Dickson, R.B., and Lin, C.Y. Deregulated activation of matriptase in breast cancer. Clin.Exp.Metastasis, 19: 639-649, 2002.

Benaud, C., Oberst, M., Hobson, J.P., Spiegel, S., Dickson, R.B., and Lin, C.Y. Sphingosine-1-phosphate present in serum-derived lipoproteins activates matriptase. J.Biol.Chem., 277: 10539-10546, 2002.

Bernet, V.J., Anderson, J.S., Saji, M., Tuttle, R.M., and Ringel, M.D. Determination of galectin-3 mRNA overexpression in papillary thyroid cancer by quantitative RT-PCR. J.Clin.Endocrinol.Metab., 87: 4792-4796, 2002.

Bhargava, P., Dordal, M., and Hawkins, M.J. Clinical trials of TNP-470. In G.M. Rubayni (ed.), Angiogenesis in Health and Disease: Basic Mechanisms and Future Directions, pp. 387-406. New York: Marcel Dekker, Inc., 2000.

Bhargava, P., Eisen, G., Holterman, D., Azumi, N., Hartmann, D.P., Benjamin, S., Hanfelt, J., Lippman, M.E., and Montgomery, E.A. Endoscopic mapping and surrogate markers for better surveillance in barrett esophagus: a study of 700 biopsy specimens. Am.J.Clin.Pathol., 114: 552-563, 2000.

Bhargava, P., Marshall, J.L., Dahut, W., Rizvi, N., Trocky, N., Williams, J.I., Hait, H., Song, S., Holroyd, K.J., and Hawkins, M.J. A phase I pharmacokinetic study of squalamine, a novel antiangiogenic agent, in patients with advanced cancers. Clin.Cancer Res., 7: 3912-3919, 2001.

Bhargava, P., Marshall, J.L., Fried, K., Williams, M., Lefebvre, P., Dahut, W., Hanfelt, J., Gehan, E., Fiquera, M., Hawkins, M.J., and Rizvi, N.A. Phase I and pharmacokinetic study of two sequences of gemcitabine and docetaxel administered weekly to patients with advanced cancer. Cancer Chemother.Pharmacol., 48: 95-103, 2001.

Blancato, J. and Dickson, R.B. c-Myc gene amplification in breast cancer. In S. Brooks and A. Harris (eds.), Breast Cancer Research Protocols. Humana Press, in press 2003.

Boulares, A.H., Zoltoski, A.J., Contreras, F.J., Yakovlev, A.G., Yoshihara, K., and Smulson, M.E. Regulation of DNAS1L3 endonuclease activity by poly(ADP-ribosyl)ation during etoposide-induced apoptosis. J Biol.Chem., 277: 372-378, 2002.

Boulares, A.H., Zoltoski, A.J., Sherif, Z.A., Yakovlev, A.G., and Smulson, M.E. The Poly(ADP-ribose) polymerase-1-regulated endonuclease DNAS1L3 is required for etoposide-induced internucleosomal DNA fragmentation and increases etoposide cytotoxicity in transfected osteosarcoma cells. Cancer Res., 62: 4439-4444, 2002.

Boulares, A.H., Zoltoski, A.J., Sherif, Z.A., Yakovlev, A.G., and Smulson, M.E. Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase-1 in sensitization of fibroblasts to tumor necrosis factor-induced apoptosis. Biochem. Biophys. Res. Commun., 290: 796-801, 2002.

Bracho, F., Krailo, M.D., Shen, V., Bergeron, S., Davenport, V., Liu-Mares, W., Blazer, B.R., Panoskaltsis-Mortari, A., van de Ven, C., Secola, R., Ames, M.M., Reid, J.M., Reaman, G., and Cairo, M.S. A phase I clinical, pharmacological and biological trial of interleukin 6 plus granulocyte-colony stimulating factor after ifosfamide, carboplatin, and etoposide in children with recurrent/refractory solid tumors: enhanced hematological responses but a high incidence of grade III/IV constitutional toxicities. Clin.Cancer Res., 7: 58-67, 2001.

Braga, M., Ringel, M.D., and Cooper, D.S. Sudden enlargement of local recurrent thyroid tumor after recombinant human TSH administration. J.Clin.Endocrinol.Metab., 86: 5148-5151, 2001.

Braithwaite, K., Abu-Ghosh, A., Anderson, L., and Cairo, M. The use of interleukin-11 to treat severe thrombocytopenia associated with Wiscott-Aldrich syndrome prior to allogeneic stem cell transplantation: decreased bleeding and platelet transfusions. J.Pediatr.Hematol.Oncol., 24: 323-326, 2002.

Burke, T.R., Jr., Yao, Z., Gao, Y., Wu, J.X., Zhu, X., Luo, J.H., Guo, R., and Yang, D. N-terminal carboxyl and tetrazole-containing amides as adjuvants to Grb2 SH2 domain ligand binding. Bioorg.Med.Chem., 9: 1439-1445, 2001.

Carignan, C.R. and Cleary, K.R. Closed-loop force control for haptic simulation of virtual environments. Haptics-E, 1: http://www.haptics-e.org, 2000.

Cassidy, J., Twelves, C., Van Cutsem, E., Hoff, P., Bajetta, E., Boyer, M., Bugat, R., Burger, U., Garin, A., Graeven, U., McKendric, J., Maroun, J., Marshall, J., Osterwalder, B., Perez-Manga, G., Rosso, R., Rougier, P., and Schilsky, R.L. First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin. Ann.Oncol., 13: 566-575, 2002.

Chang, E., Pirollo, K., and Bouker, K. Tp53 gene therapy: a key to modulating resistance to anticancer therapies? Mol.Med.Today, 6: 358-364, 2000.

Chang, E., Xu, L., and Pirollo, K. Targeted p53 gene therapy mediated radiosensitization and chemosensitization. In J.S. Gutkind (ed.), Cancer Drug Discovery and Development, pp. 521-538. Totowa, NJ: Humana Press, Inc., 2000.

Chen, H.X., Marshall, J.L., Ness, E., Martin, R.R., Dvorchik, B., Rizvi, N., Marquis, J., McKinlay, M., Dahut, W., and Hawkins, M.J. A safety and pharmocokinetic study of a mixed-backbone oligonucleotide (GEM231) targeting the type I protein kinase A by two-hour infusions in patients with refractory solid tumors. Clin. Cancer Res., 6: 1259-1266, 2000.

Chiou, C.C., Groll, A.H., Gonzalez, C.E., Callender, D., Venzon, D., Pizzo, P.A., Wood, L., and Walsh, T.J. Esophageal candidiasis in pediatric acquired immunodeficiency syndrome: clinical manifestations and risk factors. Pediatr.Infect.Dis.J., 19: 729-734, 2000.

Choi, J., Shin, B., and Cleary, K.R. Efficient volumetric ray casting for isosurface rendering. Computers Graphics, 24: 661-670, 2000.

Clarke, R. and Dickson, R.B. Animal models of endocrine responsive and unresponsive breast cancers. In J. Robertson, D.F. Hayes, and R. Nicholson (eds.), Endocrine Management of Breast Cancer, pp. 191-208. Faringdon, UK: Isis Medical Media Ltd., 2002.

Clarke, R. Human breast cancer xenografts as models of the human disease. In B.A. Teicher (ed.), Tumor Models in Cancer Research, New Jersey: Humana Press, in press 2003.

Cleary, K.R., Anderson, J., Brazaitis, M., Devey, G., DiGioia, A., Freedman, M., Gronemeyer, D., Lathan, C., Lemke, H., Long, D., Mun, S.K., and Taylor, R. Final report of the technical requirements for image-guided spine procedures workshop April 17-20, 1999, Ellicott City, Maryland, USA. Computer Aided Surg., 5: 180-215, 2000.

Cleary, K.R., Stoianovici, D., Patriciu, A., Mazilu, D., Lindisch, D., and Watson, V. Robotically assisted perispinal nerve and facet blocks: a cadaveric study. Acad.Radiol., 9: 821-825, 2002.

Cooper, R.A., Ferdig, M.T., Su, X., Ursos, L., Mu, J., Nomura, T., Fujoka, H., Fidock, D. A., Roepe, P.D., and Wellems, T.E. Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT produce chloroquine resistance and unique stereospecific quinine and quinidine responses in plasmodium falciparum. Mol.Pharmacol., 61: 1-8, 2002.

Davidson, B.J. Incidence, etiology and epidemiology. In J. P. Shah (ed.), Cancer of the Head and Neck, pp. 1-18. Ontario, Canada: BC Decker, Hamilton, 2001.

Davidson, B.J., Root, W.A., and Trock, B.J. Age and survival from squamous cell carcinoma of the oral tongue. Head Neck, 23: 273-279, 2001.

de Dios, A.C., Walling, A.E., Cameron, I., Ratcliffe, C.I., and Ripmeester, J.A. Alkali metal NMR chemical shielding as a probe of local structure: an experimental and theoretical study of Rb+ in halide lattices. J.Phys.Chem.A., 104: 908-914, 2000.

Desai, K.V., Xiao, N., Wang, W., Gang, L., Greene, J., Powell, J.I., Dickson, R.B., Furth, P.A., Hunter, K., Kucherlapati, R., Simon, R., Liu, E.T., and Green, J.E. Initiating oncogenic event determines gene expression patterns of human breast cancer models. Proc.Natl.Acad.Sci.U.S.A., 14: 6967-6972, 2002.

Duerk, J.L., Gronemeyer, D., Deli, M., Hum, B.A., Kinsella, A., Clifford, M., and Cleary, K.R. Technical requirements for image-guided spinal procedures: workshop report on intraprocedural imaging and endoscopy. Acad.Radiol., 7: 971-978, 2000.

Eldadah, B.A. and Faden, A.I. Caspase pathways, neuronal apoptosis, and CNS injury. J.Neurotrauma, 17: 811-829, 2000.

Eldadah, B.A., Ren, R.F., and Faden, A.I. Ribozyme-mediated inhibition of caspase-3 protects cerebellar granule cells from apoptosis induced by serum/potassium deprivation. J.Neurosci., 20: 179-186, 2000.

Enyedy, I.J., Lee, S.-L., Kuo, A., Dickson, R.B., Lin, C.Y., and Wang, S. Structure-based approach for the discovery of bis-benzamidines as novel inhibitors of matriptase. J.Med.Chem., 44: 1349-1355, 2001.

Enyedy, I.J., Ling, Y., Tomita, Y., Wu, X., Cao, Y., Nacro, K., Zhu, X., Yang, D., and Wang, S. Structure-based approach for discovery of small molecule Bcl-2 inhibitors. J.Med.Chem., 44: 4313-4324, 2001.

Enyedy, I.J., Zaman, W.A., Sakamuri, S., Kozikowski, A.P., Johnson, K.M., and Wang, S. Pharmacophore-based discovery of 3,4-disubstituted pyrrolidines as a novel class of monoamine transporter inhibitors. Bioorg.Med.Chem.Lett., 11: 1113-1118, 2001.

Fenton, C.L., Anderson, J.S., Patel, A.D., Solomon, B., Ringel, M.D., Francis, G.L., and Tuttle, R.M. Thyroglobulin messenger ribonucleic acid levels in the peripheral blood of children with benign and malignant thyroid disease: correlation with total body tumor burden. Pediatr.Res., 49: 429-434, 2001.

Ferreira-Gonzalez and Yanovich, S. Enhanced analytical sensitivity of a quantitative PCR for CMV using a modified nucleic-acid extraction procedure. J.Clin.Lab.Anal., 14: 32-37, 2000.

Gehan, E.A. and Tefft, M.C. Will there be resistance to the RECIST? J.Natl.Cancer Inst., 92: 179-181, 2000.

Gehan, E.A. Biostatistics in the new millennium: a consulting statistician's perspective. Stat.Methods Med.Res., 9: 3-16, 2000.

Gehan, E.A. On the ethical aspects of the testimony of statisticians in court. Stat.Methods Med.Res., 11: 363-372, 2002.

Gilchrist, L., Tomita, Y., Monde, K., Nakanishi, K., and McDermott, A. Measurements of interfluorine distances in solids. J.Magn.Reson.B., 151: 1-6, 2001.

Gokhale, P.C., Zhang, C., Newsome, J.T., Pei, J., Ahmad, I., Rahman, A., Dritschilo, A., and Kasid, U.N. Pharmacokinetics, toxicity, and efficacy of ends-modified raf antisense oligodeoxyribonucleotide encapsulated in a novel cationic liposome. Clin. Cancer Res., 8: 3611-21, 2002.

Goldman, S.C., Bracho, F., Davenport, V., Slack, R., Areman, E., Shen, V., Lenarsky, C., Weinthal, J., Hughes, R., and Cairo, M.S. Feasibility study of interleukin-11 and G-CSF following myelosuppressive chemotherapy to mobilize peripheral blood stem cells (DC34+) from heavily pretreated patients. J.Pediatr.Hematol.Oncol., 23: 300-305, 2001.

Gonzalez, C.E., Adde, M., Taylor, P., Wood, L., and Magrath, I. Impact of chemotherapy for AIDS-related malignancies in pediatric HIV disease. Ann.N.Y.Acad.Sci., 918: 362-366, 2000.

Gwinn, R., Cleary, K.R., and Medlock, M. Use of a portable CT scanner during resection of subcortical supratentorial astrocytomas of childhood. Pediatr.Neurosurg., 32: 37-43, 2000.

Hampton, R., Walker, M., Marshall, J., and Juhl, H. Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells. Oncogene, 21: 7817-7823, 2002.

Hannum, R.S., Ojeifo, J.O., Zwiebel, J.A., and McLeskey, S.W. Isolation of tumor-derived endothelial cells, synthesis and validation of cDNA libraries. Microvasc.Res., 61: 287-290, 2001.

Hoepping, A., George, C., Flippen-Anderson, J., and Kozikowski, A.P. Radical cyclization strategies for the formation of ring constrained tricyclic tropane analogues. Tetrahedron Lett., 41: 7427-7432, 2000.

Houtenbous, I., Bracho, F., Davenport, V., Slack, R., van de Ven, C., Killen, R., Shen, V., Sender, L., and Cairo, M. Autologous bone marrow transplantation for childhood acute lymphoblastic leukemia: a novel combined approach consisting of ex vivo marrow purging, modulation of multichemotherapy. Bone Marrow Transplant., 27: 145-153, 2001.

Howard, E., Zhang, H., and Roepe, P.D. A novel transporter, PfCRT, controls antimalaial drug resistance. J.Membr.Biol., 190: 1-8, 2002.

Hu, Y., Meuillet, E.J., Berggren, M., Powis, G., and Kozikowski, A.P. 3-deoxy-3-substituted-D-myo-inositol imidazolyl ether lipid phosphates and carbonate as inhibitors of the phosphatidylinositol 3-kinase pathway and cancer cell growth. Bioorg.Med.Chem.Lett., 11: 173-176, 2001.

Hu, Y., Meuillet, E.J., Qiao, L., Berggren, M., Powis, G., and Kozikowski, A.P. Synthesis and Akt kinase inhibitory properties of a id-3,4-dideoxyphosphatidylinositol ether lipid. Tetrahedron Lett., 41: 7415-7418, 2000.

Hu, Y., Qiao, L., Wang, S., Rong, S.-B., Meuillet, E.J., Berggren, M., Gallegos, A., Powis, G., and Kozikowski, A.P. 3-(hydroxymethyl)-bearing phosphatidylinositol ether lipid analogues and carbonate surrogates block PI3-k, Akt, and cancer cell growth. J.Med.Chem., 43: 3045-3051, 2000.

Hum, B.A., Feigenbaum, F., Cleary, K.R., and Henderson, F.C. Intraoperative computed tomography for complex cranio-cervial surgeries and spine tumor resections. J.Neurosurg., 47: 374-380, 2000.

Hussain, M.R. and Cullen, K.J. Molecular biomarkers in HNSCC: prognostic and therapeutic implications. Expert Rev.Anticancer Ther., 1: 116-124, 2001.

Hussein, M.R. and Baidas, S. Advances in diagnosis and management of oligodendroglioma. Expert.Rev.Anticancer Ther., 2: 520-528, 2002.

Hwang, J.J. and Marshall, J.L. Capecitabine: fulfilling the promise of oral chemotherapy. Expert.Opin.Pharmacother., 3: 733-743, 2002.

Ihara, S., Miyoshi, E., Ko, J.H., Murata, K., Nakahara, S., Honke, K., Dickson, R.B., Lin, C.Y., and Taniguchi, N. Prometastatic effect of N-acetylglucosaminyltransferase-V is due to modification and stabilization of active matriptase by adding beta 1-6 GlcNAc branching. J.Biol.Chem., 277: 16960-16967, 2002.

Jaeckle, K.A., Batchelor, T., O'Day, S.J., Phuphanich, S., New, P., Lesser, G., Cohn, A., Gilbert, M., Aiken, R., Heros, D., Rogers, L., Wong, E., Fulton, D., Gutheil, J.C., Baidas, S., Kennedy, J.M., Mason, W., Moots, P., Russell, C., Swinnen, L.J., and Howell, S.B. An open label trial of sustained-release cytarabine (DepoCyt) for the intrathecal treatment of solid tumor neoplastic meningitis. J.Neurooncol., 57: 231-239, 2002.

Jaeckle, K.A., Phuphanich, S., Bent, M.J., Aiken, R., Batchelor, T., Campbell, T., Fulton, D., Gilbert, M., Heros, D., Rogers, L., O'Day, S.J., Akerley, W., Allen, J., Baidas, S., Gertler, S.Z., Greenberg, H.S., LaFollette, S., Lesser, G., Mason, W, Recht, L., Wong, E., Chamberlain, M.C., Cohn, A., Glantz, M.J., Gutheil, J.C., Maria, B., Moots, P., New, P., Russell, C., Shapiro, W., Swinnen, L., and Howell, S.B. Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytabine. Br.J.Cancer, 84: 157-163, 2001.

Klassen, A.C., Smith, A.L., Meissner, H.I., Zabora, J., Curbow, B., and Mandelblatt, J. If we gave away mammograms, who would get them? A neighborhood evaluation of a no-cost breast cancer screening program. Prev.Med., 34: 13-21, 2002.

Knoblach, S.M., Nikoleava, M., Huang, X., Fan, L., Krajewski, S., Reed, J.C., and Faden, A. I. Multiple caspases are activated after traumatic brain injury: evidence for involvement in functional outcome. J.Neurotrauma, 19: 1155-1170, 2002.

Kovaleva, E.S., Yakovlev, A.G., Masler, E.P., and Chitwood, D.J. Human proprotein convertase 2 homologue from a plant nematode: cloning, characterization, and comparison with other species. FASEB J, 16: 1099-1101, 2002.

Kozikowski, A.P. and Baraldi, P.G. Editors anti-cancer agents. Curr.Pharma. Design, 6: 118, 2000.

Kozikowski, A.P., Nowak, I., Petukhov, P.A., Etcheberrigaray, R., Mohamed, A., Tan, M., Lewin, N., Hennings, H., Pearce, L.L., and Blumberg, P.M. New amide-bearing benzolactam-based protein kinase c modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. J.Med.Chem., 46: 364-373, 2003.

Kozikowski, A.P., Sun, H., Brognard, J., and Dennis, P.A. Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt. J.Am.Chem.Soc, 125: 1144-1145, 2003.

Kozikowski, A.P., Tuckmantel, W., and George, C. Studies in polyphenol chemistry and bioactivity. 2. Establishment of interflavan linkage regio- and stereochemistry by oxidative degradation of an o-alkylated derivative of procyanidin B2 to (R)-(-)-2,4-diphenylbutyric acid. J.Org.Chem., 65: 5371-5381, 2000.

Leonessa, F., Kim, J.H., Ghiorghis, A., Kulawiec, R., Hammer, C., Talebian, A., and Clarke, R. C-7 analogues of progesterone as potent inhibitors of the P-glycoprotein efflux pump. J.Med.Chem., 45: 390-398, 2002.

Liao, D.J. and Dickson, R.B. Role of androgens in the development, growth, and carcinogenesis of the mammary gland. J.Steroid Biochem.Mol.Biol., 80: 175-189, 2002.

Liao, D.J. and Dickson, R.B. Steroid hormone-growth factor interactions in proliferative controls of the mammary gland and breast cancer: a rapidly evolving perspective. Steroid Biochem.Mol.Biol., 80: 135-136, 2002.

Liu, A., Zhang, Y., Gehan, E., and Clarke, R. Block principal components analysis with application to gene microarray data classification. Stat.Med., 21: 3465-3474, 2002.

Liu, W., Wang, G., and Yakovlev, A.G. Identification and functional analysis of the rat caspase-3 gene promoter. J Biol.Chem., 277: 8273-8278, 2002.

Lu, J., Wang, Y., Xuan, J., Kung, S.Y., Gu, Z., and Clarke, R. Discriminative mining of gene microarray data. Proc.IEEE Neural Net. Signal Process, 11: 218-227, 2002.

Lu, L., Leonessa, F., Baynham, M.T., Clarke, R., Gimenez, F., Pham, Y.-T., Roux, F., and Wainer, I.W. The enantioselective binding of mefloquine enantiomers to P-glycoprotein determined using an immobilized P-glycoprotein liquid chromatographic stationary phase. Pharmaceut.Res., 18 : 1327-1330, 2001.

Lu, L., Leonessa, F., Clarke, R., and Wainer, I.W. Competitive and allosteric interactions in ligand binding to P-glycoprotein as observed on an immobilized P-glycoprotein liquid chromatographic stationary phase. Mol.Pharmacol., 59: 62-68, 2001.

Ma, D., Tang, G., and Kozikowski, A.P. Synthesis of 7-substituted benzolactam-V8s and their selectivity for protein kinase C isozymes. Org.Lett., 4: 2377-2380, 2002.

Ma, D., Zhang, T., Wang, G., Kozikowski, A.P., Lewin, N.E., and Blumberg, P.M. Synthesis of 7,8-disubstituted benzolactam-V8 and its binding to protein kinase C. Bioorg.Med.Chem.Lett., 11: 99-101, 2001.

Maaser, K., Hopfner, M., Jansen, A., Weisinger, G., Gavish, M., Kozikowski, A.P., Weizman, A., Carayon, P., Riecken, E.-O., Zeitz, M., and Scherubl, H. Specific ligands of the peripheral benzodiazepine receptor induce apoptosis and cell cycle arrest in human colorectal cancer cells. Br.J.Cancer, 85: 1771-1780, 2001.

Manalo, M.N., de Dios, A.C., and Cammi, R. Solvent effects on 15N NMR shielding of 1,2,4,5-tetrazine and isomeric tetrazoles: continuous set gauge transformation calculation using the polarizable continuum model. J.Phys.Chem.A., 104: 9600-9604, 2000.

Mancucci, P.M., Chediak, J., Hanna, W., Byrnes, J., Ledford, M., Ewenstein, B.M., Retzios, A.D., Kapelan, B.A., Schwartz, R.S., and Kessler, C.M. Treatment of von Willebrand disease with a high-purity factor VIII/ von Willebrand factor concentrate: a prospective, multicenter study. Blood, 99: 450-456, 2002.

Marshall, J.L. and Fox, E. Vaccine therapy. In Bleigerg, J. Kemeny, Rougier, and Wilke. (eds.), Colorectal Cancer: A Clinical Guide to Therapy London: Martin Dunitz, in press 2003.

Marshall, J.L. Capecitabine in colorectal cancer. Oncology, 15: 41-46, 2001.

Marshall, J.L. CPT-11/ 5-FU/ Leucovorin combinations as first line treatment of advanced colorectal cancer. Advanc. Colon Cancer 4: 6-9, 2000.

Marshall, J.L. New frontiers in treatment of colorectal cancer. Cancer Invest., 18: 108-111, 2000.

Marshall, J.L., Baidas, S., and Rizvi, N. Phase I trial of irinotecan and epirubicin in advanced cancer. Preliminary report. Oncology, 16: 17-19, 2002.

Marshall, J.L., Baidas, S., Bhargava, P., and Rizvi, N. Matrix metalloproteinase inhibitors in cancer: an update. Invest.New Drugs, 3: 518-524, 2000.

Marshall, J.L., Bangalore, N., El-Ashry, D., Johnson, M., Norris, B. M., Fuxman, Y., Oberst, M., Ness, E., Wojtowicz, S., Bhargava, P., Rizvi, N., Baidas, S., and Hawkins, M. J. Phase I study of prolonged infusion bryostatin-1 in patients with advanced malignancy. Cancer Biol.Ther., 1: 409-416, 2002.

Marshall, J.L., Hoyer, R.J., Toomey, M.A., Faraguna, K., Chang, P., Richmond, E., Pedicano, J., Gehan, E., Peck, R.A., Arlen, P., Tsang, K., and Schlom, J. Phase 1 study in advanced cancer patients of a diversified prime-and-boost vaccination protocol using recombinant vaccinia virus and recompinant non-replicating avipox virus to elicit anti-carcinoembryonic antigen immune responses. J.Clin.Oncol., 18: 3964-3973, 2000.

Marshall, J.L., Rizvi, N., Kauh, J., Dahut, W., Figuera, M., Kang, M. H., Figg, W.D., Wainer, I., Chaissang, C., Li, M.Z., and Hawkins, M.J. A phase I trial of depsipeptide (FR901228) in patients with advanced cancer. J Exp.Ther.Oncol, 2: 325-332, 2002.

Mavromatis, B.H. and Cheson, B. New strategies for the treatment of indolent non-Hodgkin's lymphomas. Oncology Spectrums, 2: 706-719, 2001.

Meehan, K.R., Slack, R., Gehan, E., Herscowitz, H.B., Areman, E.M., Ebadi, M., Cairo, M.S., and Lippman, M.E. Mobilization of peripheral blood stem cells with paclitaxel and rhG-CSF in high-risk breast cancer patients. J.Hematother.Stem Cell Res., 11: 415-421, 2002.

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