Cancer Type: EsophagusHospitals offering this trial
CALGB 80803: Randomized Phase II Trial of PET Scan-Directed Combined Modality Therapy in Esophageal Cancer.
This study is for patients who
have esophageal cancer that is limited to the local area around the esophagus.
The purpose of this study is to learn if we can improve the outcomes for patients with esophageal cancer by using PET/CT scans to determine whether or not a particular chemotherapy regimen is showing any effect on the tumor. We are trying to learn if PET/CT response can be used as a way to better direct therapy for this type of cancer.
PET scans show the activity of cells and can help your doctor to measure how active tumor cells are. Previous studies among patients with esophageal cancer have shown that comparing PET/CT scans prior to starting chemotherapy and after receiving several weeks of therapy can predict those who are poor responders to chemotherapy and those who have a better response to chemotherapy. We are using two different chemotherapy regimens, which are FDA approved for this type of cancer, as induction chemotherapy, meaning the chemotherapy is given first, prior to radiation therapy and surgery. The two chemotherapy regimens have been studied in esophageal cancer and have been found to have similar effects on tumors. The two chemotherapy regimens are FOLFOX6 and carboplatin/ paclitaxel.
This is a Phase II randomized trial. Phase II trials are studies that evaluate the efficacy of a treatment approach (how well the treatment works). This study also includes a randomization which means that subjects will be randomly assigned to one of the two treatment groups.
Contact : Karen Vogel